Topographic anatomy of ascending and descending neurons of the supraesophageal, meso- and metathoracic ganglia in paleo- and neopterous insects

Severina, I. Yu.; Isavnina, I. L.; Knyazev, A. N.

doi:10.1134/s0022093016050082

Cited by 11 publications

(4 citation statements)

References 32 publications

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“…The DNs are thus a strategic target for investigating sensory-motor processing, and a wiring diagram of their connectivity is critical to understanding how the nervous system controls behavior ( Burrows, 1996 ; Drew et al, 2004 ). Although previous studies have revealed the broad organization of descending pathways in a range of species ( Breidbach, 1990 ; Kanzaki et al, 1994 ; Staudacher, 1998 ; Okada et al, 2003 ; Cardona et al, 2009 ; Hsu and Bhandawat, 2016 ; Severina et al, 2016 ; Kien and Altman, 1984 ; Strausfeld et al, 1984 ; Strausfeld, 2012 ; Lemon, 2008 ), uncovering the sensory-motor mapping represented by the DNs requires analysis of inputs and outputs with single-cell resolution. The genetic model organism, Drosophila melanogaster , offers an opportunity to pursue such a systematic analysis.…”

Section: Introductionmentioning

confidence: 99%

The functional organization of descending sensory-motor pathways in Drosophila

Namiki

Dickinson

Wong

et al. 2018

eLife

291

438

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In most animals, the brain controls the body via a set of descending neurons (DNs) that traverse the neck. DN activity activates, maintains or modulates locomotion and other behaviors. Individual DNs have been well-studied in species from insects to primates, but little is known about overall connectivity patterns across the DN population. We systematically investigated DN anatomy in Drosophila melanogaster and created over 100 transgenic lines targeting individual cell types. We identified roughly half of all Drosophila DNs and comprehensively map connectivity between sensory and motor neuropils in the brain and nerve cord, respectively. We find the nerve cord is a layered system of neuropils reflecting the fly’s capability for two largely independent means of locomotion -- walking and flight -- using distinct sets of appendages. Our results reveal the basic functional map of descending pathways in flies and provide tools for systematic interrogation of neural circuits.

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Section: Introductionmentioning

confidence: 99%

The functional organization of descending sensory-motor pathways in Drosophila

Namiki

Dickinson

Wong

et al. 2018

eLife

291

438

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show abstract

“…The posterior ventral part of the brain can be densely labeled using backfill labeling from the neck connective in insects 5 – 7 , 10 , 11 . A systematic analysis of individual DN morphology revealed that most DNs originate from the area known as the posterior slope (PS) in Drosophila 9 .…”

Section: Introductionmentioning

confidence: 99%

Descending neurons from the lateral accessory lobe and posterior slope in the brain of the silkmoth Bombyx mori

Namiki

Wada²,

Kanzaki³

2018

Sci Rep

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A population of descending neurons connect the brain and thoracic motor center, playing a critical role in controlling behavior. We examined the anatomical organization of descending neurons (DNs) in the brain of the silkmoth Bombyx mori. Moth pheromone orientation is a good model to investigate neuronal mechanisms of behavior. Based on mass staining and single-cell staining, we evaluated the anatomical organization of neurite distribution by DNs in the brain. Dense innervation was observed in the posterior–ventral part of the brain called the posterior slope (PS). We analyzed the morphology of DNs innervating the lateral accessory lobe (LAL), which is considered important for moth olfactory behavior. We observed that all LAL DNs also innervate the PS, suggesting the integration of signals from the LAL and PS. We also identified a set of DNs innervating the PS but not the LAL. These DNs were sensitive to the sex pheromone, suggesting a role of the PS in motor control for pheromone processing. Here we discuss the organization of descending pathways for pheromone orientation.

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“…However, in the dragonfly Aeschna grandis , there are 3–4 large DN neurons in the same cluster; the diameters are about 60–80 µm. In the same cluster of P. americana , most giant DN neurons are about 35–50 µm [ 18 ]. The cervical giant fiber neuron (CGF) in D. melanogaster and the giant descending neuron (GDN) in flies Musca and Calliphora are also homologous neurons to the DNp of H. armigera .…”

Section: Discussionmentioning

confidence: 99%

“…The backfilling of the axons from the neck connective is an elegant approach for examining the DNs, which was evaluated in D. melanogaster compared with the labeling of genetic marks [ 17 ]. The roles of DNs may be directly related to the specific behavior of insects, and their morphologies and distributions are species-specific [ 18 ]. Therefore, exploring the anatomical distribution of DNs in more species is essential for understanding the neuroethological principles of insects.…”

Section: Introductionmentioning

confidence: 99%

Distribution and Organization of Descending Neurons in the Brain of Adult Helicoverpa armigera (Insecta)

Liu

Yang

Sun

et al. 2023

Insects

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The descending neurons (DNs) of insects connect the brain and thoracic ganglia and play a key role in controlling insect behaviors. Here, a comprehensive investigation of the distribution and organization of the DNs in the brain of Helicoverpa armigera (Hübner) was made by using backfilling from the neck connective combined with immunostaining techniques. The maximum number of DN somata labeled in H. armigera was about 980 in males and 840 in females, indicating a sexual difference in DNs. All somata of DNs in H. armigera were classified into six different clusters, and the cluster of DNd was only found in males. The processes of stained neurons in H. armigera were mainly found in the ventral central brain, including in the posterior slope, ventral lateral protocerebrum, lateral accessory lobe, antennal mechanosensory and motor center, gnathal ganglion and other small periesophageal neuropils. These results indicate that the posterior ventral part of the brain is vital for regulating locomotion in insects. These findings provide a detailed description of DNs in the brain that could contribute to investigations on the neural mechanism of moth behaviors.

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Topographic anatomy of ascending and descending neurons of the supraesophageal, meso- and metathoracic ganglia in paleo- and neopterous insects

Cited by 11 publications

References 32 publications

The functional organization of descending sensory-motor pathways in Drosophila

The functional organization of descending sensory-motor pathways in Drosophila

Descending neurons from the lateral accessory lobe and posterior slope in the brain of the silkmoth Bombyx mori

Distribution and Organization of Descending Neurons in the Brain of Adult Helicoverpa armigera (Insecta)

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