Topographic brain measures of human pain and pain responsivity

Chen, Andrew C. N.; Dworkin, Samuel F.; Haug, Joanna; Gehrig, John D.

doi:10.1016/0304-3959(89)90125-5

Cited by 121 publications

(72 citation statements)

References 19 publications

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“…14 and 15), cold pressor tolerance (e.g., ref. 16), and pain associated with manual palpation of tender points in fibromyalgia sufferers (17). In the cold pressor test, Chen et al (16,18) consistently observe dichotomous responses, with a minority ''painsensitive'' group tolerating the test for a mean duration of 50 sec and a majority ''pain-tolerant'' group able to tolerate the test for the full 300-sec duration.…”

Section: The Scope Of Individual Variability To Pain and Analgesiamentioning

confidence: 99%

The genetic mediation of individual differences in sensitivity to pain and its inhibition

Mogil

1999

Proc. Natl. Acad. Sci. U.S.A.

384

220

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The underlying bases of the considerable interindividual variability in pain-related traits are starting to be revealed. Although the relative importance of genes versus experience in human pain perception remains unclear, rodent populations display large and heritable differences in both nociceptive and analgesic sensitivity. The identification and characterization of particularly divergent populations provides a powerful initial step in the genetic analysis of pain, because these models can be exploited to identify genes contributing to the behavior-level variability. Ultimately, DNA sequence differences representing the differential alleles at pain-relevant genes can be identified. Thus, by using a combination of ''top-down'' and ''bottom-up'' strategies, we are now able to genetically dissect even complex biological traits like pain. The present review summarizes the current progress toward these ends in both humans and rodents.

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Section: The Scope Of Individual Variability To Pain and Analgesiamentioning

confidence: 99%

The genetic mediation of individual differences in sensitivity to pain and its inhibition

Mogil

1999

Proc. Natl. Acad. Sci. U.S.A.

384

220

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“…The brain mechanism and EEG pattern during pain generally is due to sensory processing and to all effective and cognitive processes linked to sensory processing [5], [8]. It seems that the lack of clear and consistent answer to this question is related to the methods used for analysis.…”

Section: Introductionmentioning

confidence: 99%

Pain Level Measurement Using Discrete Wavelet Transform

Vatankhah¹,

Toliyat²

2016

IJET

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Abstract-Experimental pain has extensively been used as a tool for investigating neural mechanisms and the psychological factors involved in pain processing. The detection of existence and/or level of pain is vital when verbal information is not present e.g. for infants, disabled persons, anesthetized patients and animals also. This study shows that there is a firm relation between Electroencephalogram (EEG) and chronic pain levels and EEG can be used as a reliable tool for detecting, measuring and diagnosing pain levels in humans.This paper proposed a use of wavelet coherency in order to estimate the three pain levels and its usage as an index for pain measurement. Besides, wavelet coefficients are studied to show consistencies with EEG dynamic were extracted to provide the feature vector. A Hidden Markov Model (HMM) and a support vector machine (SVM) scheme was used for pain levels classification. This study confirms the hypothesis that brain pattern under the chronic pain mental task is mapped on EEG and the dependency of brain patterns to EEG is possible and detectable.Index Terms-Chronic pain index, electroencephalogram, SVM, HMM.

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“…6 -9 Moreover, changes in electroencephalographic (EEG) spectra in humans have been shown to reflect changes in cerebral activity associated with the cognitive perception of pain. 10,11 Hence, EEG responses to noxious stimulation may be useful in determining the time at which the neurological apparatus required for conscious perception of sensations, including pain, becomes functional.…”

mentioning

confidence: 99%

“…This minimal anaesthesia model is based on observations that EEG responses to noxious stimulation in conscious and anaesthetized animals are similar to those of conscious humans exposed to painful stimuli. 11,32,33 The model has the advantage of being humane as it avoids any conscious perception of pain, and it also minimizes EEG artefacts by markedly reducing spontaneous muscular activity. Although the minimal anaesthesia model does not demonstrate that animals are capable of conscious perception, it does allow inferences to be drawn regarding whether or not the cerebral cortex is capable of responding to systemic stimulation at the different ages investigated.…”

mentioning

confidence: 99%

Developmental changes in the electroencephalogram and responses to a noxious stimulus in anaesthetized tammar wallaby joeys (Macropus eugenii eugenii)

Diesch

Mellor²,

Johnson

et al. 2010

Lab Anim

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The tammar wallaby joey is born extremely immature and most of its neurological development occurs in the maternal pouch. It is not known at what in-pouch age functions such as conscious sensory perception commence. We determined the electroencephalographic (EEG) responses to noxious stimulation in lightly anaesthetized tammar wallaby joeys. Baseline median (F50) and spectral edge (F95) frequencies, total power (Ptot) and frequency spectra between 1 and 30 Hz of the EEG power spectrum were determined. Joeys aged less than 127 days showed little or no EEG activity. Prolonged periods of spontaneous EEG activity were present by 142 days. This activity increased, as did the power in all frequencies, while the duration of any intervening isoelectric periods decreased with increasing in-pouch age. EEG responses to a noxious stimulus (toe clamping) changed with increasing in-pouch age as there was no response from joeys aged 94-127 days (no EEG), a minimal decrease in the F50 in those aged between 142 and 181 days (P ¼ 0.052) and a greater decrease in the F50 in those aged between 187 and 261 days (P , 0.001). The pattern of these changes, which presumably reflects anatomical and functional maturation of the cerebral cortex, is similar to, but develops more slowly than, that reported in the rat. The opening of the eyes and development of the pelage are discussed as markers of when brain development may be sufficient for joeys to consciously perceive noxious sensations including pain.

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Topographic brain measures of human pain and pain responsivity

Cited by 121 publications

References 19 publications

The genetic mediation of individual differences in sensitivity to pain and its inhibition

The genetic mediation of individual differences in sensitivity to pain and its inhibition

Pain Level Measurement Using Discrete Wavelet Transform

Developmental changes in the electroencephalogram and responses to a noxious stimulus in anaesthetized tammar wallaby joeys (Macropus eugenii eugenii)

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