Topographic organization of central terminal region of different sensory branches of the rat mandibular nerve

Takemura, Motohide; Sugimoto, Tomosada; Sakai, Akira

doi:10.1016/0014-4886(87)90217-2

Cited by 100 publications

(63 citation statements)

References 30 publications

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“…A tracer injection into the ganglion or the peripheral nerve demonstrates contralateral projection of trigeminal primary neurons of rats. Their axons cross the midline at the level of pyramidal decussation and reach the dorsomedial edge of the contralateral MDH (Jacquin et al, 1982(Jacquin et al, , 1983Takemura et al, 1987;Pfaller and Arvidsson, 1988;Marfurt and Rajchert, 1991). The trajectory of CGRP-ir axons in this study resembled that of the tracer-labeled axons in the previous studies, and we assume that some of the contralaterally projecting trigeminal primary neurons contained CGRP.…”

Section: Convergent Primary Afferent Inputs To the Bstcsupporting

confidence: 55%

“…The dorsomedial nucleus, first described by Åstrøm (1953), can be distinguished from the rest of the Vo by its cytoarchitecture and is highly developed in rodents. The nucleus is known to receive trigeminal primary projection from exclusively intraoral structures (Arvidsson and Gobel, 1981;Marfurt, 1981;Jacquin et al, 1983;Marfurt and Turner, 1984;Shigenaga et al, 1986aShigenaga et al, ,b, 1989Takemura et al, 1987Takemura et al, , 1991. Prominent CGRP-and SP-ir projection of exclusively trigeminal primary neurons as shown in this study has added another characteristic that distinguishes the rodent dorsomedial nucleus from the rest of the BSTC.…”

Section: Cgrp-ir Primary Afferent Projection To the Rostral Subdivisimentioning

confidence: 73%

“…Clinical experiences, as well as the knowledge accumulated through experimental studies, may suggest implication of this nucleus in the mechanisms of pain perception (see below). On the other hand, the narrow area adjacent to the TrV is the terminal field of trigeminal primary neurons innervating the hairy skin of the periphery of the face (Jacquin et al, 1983;Shigenaga et al, 1986a;Takemura et al, 1987Takemura et al, , 1991. This area of the Vo received convergent CGRP-and SP-ir projection of trigeminal and nontrigeminal origins.…”

Section: Cgrp-ir Primary Afferent Projection To the Rostral Subdivisimentioning

confidence: 97%

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Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

et al. 1997

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Substance P (SP) is implicated in transmission of primary afferent nociceptive signals. In primary neurons, SP is colocalized with calcitonin gene-related peptide (CGRP), which is another neuropeptide marker for small to medium primary neurons. CGRP coreleased with SP augments the postsynaptic effect of SP and thereby modulates the nociceptive transmission. This study demonstrates the distribution of CGRP-like immunoreactivity (-ir) and SP-ir in the lower brainstem of normal rats and after trigeminal rhizotomy or tractotomy at the level of subnucleus interpolaris (Vi). By comparing the results obtained from normal and deafferented rats, we analyzed the central projection of trigeminal primary nociceptors. The CGRP-immunoreactive (-ir) trigeminal primaries projected to the entire rostrocaudal extent of the spinal trigeminal nucleus, the principal nucleus (PrV), the paratrigeminal nucleus (paraV), and the lateral subnucleus of solitary tract nucleus (STN) on the ipsilateral side. The trigeminal primaries projecting to the spinal trigeminal nucleus, paraV and STN also contained SP-ir. The ipsilateral trigeminal primaries were the exclusive source of CGRP-ir terminals in the PrV, the Vi and the dorsomedial nucleus within the subnucleus oralis (Vo). The medullary dorsal horn (MDH) and the lateral edge of Vo received convergent CGRP-ir projection from the ipsilateral trigeminal primaries and other neurons. The glossopharyngeal and vagal primaries are candidates for the source of CGRP-ir projection to the Vo and the MDH, while the dorsal root axons supply the MDH with CGRP-ir terminals. In addition, contralateral primary neurons crossing the midline appear to contain CGRP and to terminate in the MDH.

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Section: Convergent Primary Afferent Inputs To the Bstcsupporting

confidence: 55%

Section: Cgrp-ir Primary Afferent Projection To the Rostral Subdivisimentioning

confidence: 73%

Section: Cgrp-ir Primary Afferent Projection To the Rostral Subdivisimentioning

confidence: 97%

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Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

et al. 1997

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“…Molenaar (1978b) noted that this nucleus resembles the lateral descending nucleus of infrared-sensitive snakes, and we suggest that it also has striking similarities to specific parts of CUE in pigeon (see Marfurt and Rajchert, 1991). The paratrigeminal nucleus of the rat and cat, for instance, is located lateral to the descending trigeminal tract at the level of the caudal parts of nucleus interpolaris and receives a dense, patchy projection from the trigeminal ganglion or intraoral nerves and a projection from pharyngeal and soft palatal branches via the vagus and glossopharyngeal nerves (Altschuler et al, 1989) and is substance P positive (Shigenega et al, 1986a,b;Takemura et al, 1987;Phelan and Falls, 1989;Marfurt and Rajchert, 1991). Similarly, in pigeon, the part of CUE that is located lateral to TTD at levels immediately rostral to the obex also receives a dense, patchy trigeminal projection and a specific projection from the vagus nerve (Katz and Karten, 1983) and is also substance P positive in a dense, patchy way (Wild and Zeigler, unpublished observations).…”

Section: Projections To Extratrigeminal Regionsmentioning

confidence: 96%

Central projections and somatotopic organisation of trigeminal primary afferents in pigeon (Columba livia)

Wild

Zeigler

1996

J. Comp. Neurol.

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Injections of cholera toxin B-chain conjugated to horseradish peroxidase into individual peripheral branches of the trigeminal nerve or into the trigeminal ganglion showed that an ascending trigeminal tract (TTA) terminated in distinct ventral and dorsal divisions of the principal sensory nucleus (PrVv and PrVd, respectively), and a descending tract (TTD) terminated within pars oralis, pars interpolaris, and pars caudalis divisions of the nucleus of TTD (nTTD) and within the dorsal horn of the first six cervical spinal segments. In PrVd, mandibular, ophthalmic, and maxillary projections were predominantly located dorsally, ventrally, and medially, respectively. In nTTD, mandibular projections lay dorsomedially, ophthalmic projections lay ventrolaterally, and maxillary projections lay in between. At caudal medullary and spinal levels, mandibular projections were situated medially, ophthalmic projections were situated laterally, and maxillary projections were situated centrally. The terminations within the dorsal horn were most dense in laminae III and IV and were least dense in lamina II, with laminae III-IV also receiving topographically organised contralateral projections. Extratrigeminal projections were mainly to the external cuneate nucleus by way of a lateral descending trigeminal tract (lTTD; Dubbeldam and Karten [1978] J. Comp. Neurol. 180:661-678) and to the region of the tract of Lissauer and lamina I of the dorsal horn. Other projections were to a region medial to the apex of pars interpolaris, to the nuclei ventrolateralis anterior (Vla) and presulcalis anterior (Pas) of the solitary complex, and sparsely to the lateral reticular formation (plexus of Horsley) ventral to TTD. No projections were seen to the trigeminal motor nuclei or to the cerebellum.

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“…Comparisons with the distribution of central terminals seen after transganglionic labeling of trigeminal [Jacquin et al, 1983;Takemura et al, 1987], upper cervical [Pfaller and Arvidsson, 1988;Neuhuber and Zenker, 1989], or vagal afferent nerves [Contreras et al, 1982], suggested a high percentage of Fos-positive neurons produced at the dPa5 and Vc/C2 junction region resulted from direct input from primary afferent fibers. By contrast, Fos-LI produced at the Vi/Vc-vl transition region more likely represented third-or higher-order neurons since few primary afferent fibers project from the TMJ region to this brainstem area.…”

Section: Fos-li As a Marker For Primary Afferent Input From The Tmj Rmentioning

confidence: 99%

Sex Differences in Brainstem Neural Activation after Injury to the TMJ Region

Bereiter¹

2001

Cells Tissues Organs

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The basis for a higher prevalence of painful temporomandibular disorders (TMD) among women than men is not known. The present study used Fos-like immunoreactivity (Fos-LI) to quantify the pattern and magnitude of neural activation within the trigeminal brainstem complex of male and female rats caused by acute inflammatory injury to the temporomandibular joint (TMJ) region. Also, Fos-LI was assessed in animals given morphine, a preferential mu opioid receptor agonist, or U50,488H, a selective kappa opioid agonist, prior to TMJ injury to determine if opioid modulation of neural activation was similar in males and females. The general pattern of Fos-LI after TMJ injury was similar in males and females. This pattern was characterized by a high density of Fos-positive neurons in the dorsal paratrigeminal nucleus (dPa5), subnucleus interpolaris/caudalis transition region (Vi/Vc-vl), and in the superficial laminae at the subnucleus caudalis/upper cervical spinal cord (Vc/C2) junction ipsilateral to TMJ injury. In contrast to other regions the number of Fos-positive neurons produced at the Vc/C2 junction was proportional to the concentration of mustard oil injected into the TMJ region. In addition, proestrus females produced higher levels of Fos-LI at the Vc/C2 junction than diestrus females or males. Morphine caused a greater dose-related reduction in Fos-LI at the dPa5 and Vc/C2 junction in males than females. By contrast, U50,488H caused a dose-related reduction in Fos-LI only at the Vc/C2 junction of proestrus females. These results support the hypothesis that the Vc/C2 junction region plays a critical role in the integration of pain signals originating from the TMJ region and may underlie sex differences in sensory processing related to TMJ pain.

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Topographic organization of central terminal region of different sensory branches of the rat mandibular nerve

Cited by 100 publications

References 30 publications

Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

Central projection of calcitonin gene-related peptide (CGRP)- and substance P (SP)-immunoreactive trigeminal primary neurons in the rat

Central projections and somatotopic organisation of trigeminal primary afferents in pigeon (Columba livia)

Sex Differences in Brainstem Neural Activation after Injury to the TMJ Region

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