Topographic organization of the cerebellothalamic projections in the rat. An autoradiographic study

Angaut, P; Cicirata, F; Serapide, Maria Francesca

doi:10.1016/0306-4522(85)90221-0

Cited by 80 publications

(55 citation statements)

References 32 publications

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“…Furthermore, after tracer injections into the most medial portion of CblNc, we noted projections to the inferior olivary nucleus (Legendre and Courville, 1987;Yatim et al, 1995) but failed to trace fibers to the thalamus. This is compatible with the data in other species, in which the medial cerebellar nuclear efferents are among the least prominent cerebellothalamic projections and are known to arise primarily from the caudal CblNc (Bentivoglio and Kuypers, 1982;Carpenter and Batton, 1982;Angaut et al, 1985;Wiesendanger and Wiesendanger, 1985). It is unknown whether we injected too little tracer into this caudal region or whether this region is poorly represented in the Echinops, which shows the least developed CblNc among the mammals investigated (78 compared with, e.g., 124 in the erinaceous hedgehog; Matano et al, 1985).…”

Section: Discussionsupporting

confidence: 83%

“…On the basis of its location ventrolateral to the nucleus submedius, VAm may be compared best with the nucleus ventralis medialis (VM) in the rat. In both the rat and the tenrec, the cerebellar projections to the VM/VAm originate predominantly in the CblL, whereas their medial cerebellar nucleus-in contrast to the cat (Angaut and Bowsher, 1970;Nakano et al, 1980;Jiménez-Castellanos and Reinoso-Suarez, 1985;Anderson and de Vito, 1987)-appears to be involved minimally in this projection (Herkenham, 1979;Angaut et al, 1985). It may be noted that, among the tenrec's cerebellar nuclei, it is also the CblL that projects most heavily to the superior colliculus (Kü nzle, 1997).…”

Section: Ventromedial Nuclear Complexmentioning

confidence: 93%

“…The prominence of the cerebellar projection to the VAm, in addition, is accentuated by the fact that this projection is bilateral, whereas the cerebellar projections to the remaining portions of the VAC are exclusively contralateral. In the rat, on the other hand, there are bilateral projections to the nucleus ventralis lateralis (VL), but the presence of bilateral projections is questionable with regard to the VM (Faull and Carman, 1978;Angaut et al, 1985;Aumann et al, 1994). It is difficult to speculate about the functional significance of these findings, because the other connections of the VAm are unknown, particularly its nigral afferents and its cortical efferents.…”

Section: Ventromedial Nuclear Complexmentioning

confidence: 95%

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Thalamic territories innervated by cerebellar nuclear afferents in the hedgehog tenrec,Echinops telfairi

Künzle

1998

J. Comp. Neurol.

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To gain more insight into the evolution and functional significance of cerebrocerebellar circuits, the cerebellothalamic projections were studied with anterograde tracer substances in the Madagascan lesser hedgehog, tenrec. This insectivore shows one of the lowest size indices among mammals for both the cerebellar nuclei and the neocortex. Almost all cerebellodiencephalic target areas found in the tenrec have been described in other mammals. The intensity and extent of particular projections, however, vary considerably in the tenrec compared with the other mammals investigated so far. The most remarkable finding may be the tenrec's cerebellar projection to the nucleus ventralis medialis. This projection is the most prominent cerebellothalamic projection and originates in predominantly the lateral portion of the cerebellar nuclear complex. The projection to the caudolateral portion of the ventralis anterior complex (VAC) is located immediately rostral to the area receiving ascending somatosensory afferents and appears to originate, in particular, from the intermediate cerebellar nuclear complex. Another cerebellothalamic focus of terminations lies in the paralamellar region of the VAC, whereas the proper intralaminar nuclei, at best, receive a sparse cerebellar input. A faint-to-moderate projection, on the other hand, has been traced consistently to the ventral portion of the lateralis posterior-pulvinar complex and the adjacent dorsal geniculate nucleus. In addition, there are prominent cerebellosubthalamic projections to the zona incerta and the ventral geniculate nucleus. The latter projection is confined mainly to the ventralmost subdivision, which has been shown previously to receive ascending somatosensory, but not retinal, afferents. With the exception of the nucleus ventralis medialis, the projections were essentially confined to the contralateral side.

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Section: Discussionsupporting

confidence: 83%

Section: Ventromedial Nuclear Complexmentioning

confidence: 93%

Section: Ventromedial Nuclear Complexmentioning

confidence: 95%

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Thalamic territories innervated by cerebellar nuclear afferents in the hedgehog tenrec,Echinops telfairi

Künzle

1998

J. Comp. Neurol.

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“…The caudorostral arrangement thus de fined within the NL is quite similar to that of the dentatothalamocortical pathway [see Angaut et al, 1985;Cicirata et al, 1986]. It is known that at least a majority of the dentatorubral fibers are collaterals of the dentatothalamic axons [Cajal, 1911].…”

Section: Discussionmentioning

confidence: 89%

“…A detailed description of the techniques employed has been reported previously [Angaut et al, 1985]. Briefly, pressure injections (60-I00nl of a 30-60 ¿iCi/ul) of tritiated proline or leucine were made in the cerebellar nuclear zone un der chloral hydrate anesthesia.…”

Section: Methodsmentioning

confidence: 99%

The Dentatorubral Projection. An Autoradiography Study in Rats

Angaut¹,

Cicirata²,

Serapide

1987

Brain Behav Evol

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Although the dentatorubral projection is known to end specifically in the parvocellular part of the red nucleus, its topographical arrangement has never been elucidated. We therefore selectively injected the lateral cerebellar nucleus (homologous to the dentate nucleus of primates) of adult Wistar rats with tritiated leucine or proline in order to trace the dentatorubral boundaries. In all cases, the projection was found to extend rostrocaudally throughout the parvocellular red nucleus; dorsoventrally as well as mediolaterally, the fibers were distributed according to the location of the injection within the lateral cerebellar nucleus. Hence, caudal regions of the lateral nucleus fibers dorsally at the rubral level, rostral regions project ventrally. This dorsoventral arrangement matches the segregation of the parvocellular red nucleus into a dorsal 'forelimb' region and a ventral 'hindlimb' region corresponding to its spinal efferents. In addition, only the ventral part of the lateral cerebellar nucleus, particularly the parvocellular region (subnucleus lateralis parvocellularis), projects to the lateral aspect of the parvocellular red nucleus. These results suggest a common pattern of organization of the dentorubral and the dentatothalamic projections.

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Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: A study combining anterograde tracing with immunogold labeling in the rat

Schwarz

Schmitz

1997

J. Comp. Neurol.

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The pontine nuclei (PN) and the nucleus reticularis tegmenti pontis (NRTP) are sources of an excitatory projection to the cerebellar cortex via mossy fibers and a direct excitatory projection to the cerebellar nuclei. These precerebellar nuclei, in turn, receive a feedback projection from the cerebellar nuclei, which mostly originate in the lateral nucleus (LN). It has been suggested that the feedback projection from the LN partially uses gamma-aminobutyric acid (GABA) as a transmitter. We tested this hypothesis by using a combination of anterograde tracing (biotinylated dextran amine injection into the LN) and postembedding GABA and glutamate immunogold histochemistry. The pattern of labeling in the PN and the NRTP was compared with that of cerebellonuclear terminals in two other target structures, the parvocellular part of the nucleus ruber (RNp) and the ventromedial and ventrolateral thalamus (VM/VL). The projection to the inferior olive (IO), which is known to be predominantly GABAergic, served as a control. A quantitative analysis of the synaptic terminals labeled by the tracer within the PN, the NRTP, and the VL/VM revealed no GABA immunoreactivity. Only one clearly labeled terminal was found in the RNp. In contrast, 72% of the terminals in the IO were clearly GABA immunoreactive, confirming the reliability of our staining protocol. Correspondingly, glutamate immunohistochemistry labeled the majority of the cerebellonuclear terminals in the PN (88%), the NRTP (90%), the RNp (93%), and the VM/VL (63%) but labeled only 5% in the IO. These data do not support a role for GABAergic inhibition either in the feedback systems from the LN to the PN and the NRTP or within the projections to the RNp and the VM/VL.

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Topographic organization of the cerebellothalamic projections in the rat. An autoradiographic study

Cited by 80 publications

References 32 publications

Thalamic territories innervated by cerebellar nuclear afferents in the hedgehog tenrec,Echinops telfairi

Thalamic territories innervated by cerebellar nuclear afferents in the hedgehog tenrec,Echinops telfairi

The Dentatorubral Projection. An Autoradiography Study in Rats

Projection from the cerebellar lateral nucleus to precerebellar nuclei in the mossy fiber pathway is glutamatergic: A study combining anterograde tracing with immunogold labeling in the rat

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