Topographical organization of human corpus callosum: An fMRI mapping study

Fabri, Mara; Polonara, Gabriele; Mascioli, Giulia; Salvolini, U.; Manzoni, T

doi:10.1016/j.brainres.2010.11.039

Cited by 109 publications

(99 citation statements)

References 53 publications

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“…According to results of our study, the relative mean distances of the highest probabilistic locations for the precentral knob PMC, hand M1, leg M1, and precentral knob S1 TCF were to results of previous DTI studies [13][14][15][16]20].…”

Section: Resultssupporting

confidence: 76%

“…By contrast, recent advancements in diffusion tensor tractography (DTT), derived from DTI, have now allowed visualization of the architecture and integrity of TCF in three dimensions [8][9][10][11]. Many DTT studies have reported on the topography of TCF [12][13][14][15][16][17][18][19][20][21]. However, little is known about detailed anatomical information on TCF that can be easily applied for clinical purposes [14,15,22].…”

Section: Introductionmentioning

confidence: 99%

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Anatomical location of transcallosal sensorimotor fibers in the human brain: Diffusion tensor tractography study

Seo

Jang

2013

Translational Neuroscience

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Many diffusion tensor tractography (DTT) studies have reported on the topography of transcallosal fibers (TCF). However, little detailed anatomical information on TCF that can be easily applied for clinical purposes is known. Using probabilistic DTT, we attempted to determine the anatomical location of the TCF for motor and sensory function in the human brain. A total of 51 healthy subjects were recruited for this study. Diffusion tensor images (DTIs) were obtained at 1.5 T, and four TCF for the premotor cortex (PMC), the primary motor cortex (M1) for hand and leg, and the primary somatosensory cortex (S1) were obtained using FMRIB software. Locations of the TCF were defined as the highest probabilistic location on the midsagittal slice of the corpus callosum. We measured distances between the most anterior and posterior points of the corpus callosum. The relative mean distances of the highest probabilistic location for the precentral knob PMC (Brodmann area 6 anterior to the precentral knob), hand M1, leg M1, and precentral knob S1 (postcentral gyrus posterior to the precentral knob) TCF were 48.99%, 59.78%, 67.93%, and 73,48% from the most anterior point of the CC, respectively. According to our findings, the precentral knob PMC, hand M1, leg M1, and precentral knob S1 TCF were located at the anterior body, posterior body, posterior body, and isthmus according to Witelson's classification, respectively.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Anatomical location of transcallosal sensorimotor fibers in the human brain: Diffusion tensor tractography study

Seo

Jang

2013

Translational Neuroscience

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“…For instance, the corona radiata, a collection of fiber bundles that extend from the internal capsule to cerebral cortex (Schmahmann et al, 2008) basal ganglia, and spinal cord, has been associated with altered taste perception when lesioned (Onoda et al, 2012), and lesions in the anterior corpus callosum were associated with altered taste signal transmission (Fabri et al, 2011). The external capsule lies between putamen medially and claustrum laterally, connecting ventral and medial prefrontal cortices with limbic regions via fibers from the uncinate fasciculus and inferior fronto-occipital fasciculus (Schmahmann et al, 2008), and white matter FA in these pathways predicted in the past brain reward activation (Olson et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Shott

Pryor

Yang

et al. 2015

Neuropsychopharmacol

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Anorexia nervosa is a severe psychiatric disorder associated with reduced drive to eat. Altered taste-reward circuit white matter fiber organization in anorexia nervosa after recovery could indicate a biological marker that alters the normal motivation to eat. Women recovered from restricting-type anorexia (Recovered AN, n = 24, age = 30.3 ± 8.1 years) and healthy controls (n = 24, age = 27.4 ± 6.3 years) underwent diffusion weighted imaging of the brain. Probabilistic tractography analyses calculated brain white matter connectivity (streamlines) as an estimate of fiber connections in taste-reward-related white matter tracts, and microstructural integrity (fractional anisotropy, FA) was assessed using tract-based spatial statistics. Recovered AN showed significantly (range Po0.05-0.001, Bonferroni corrected) greater white matter connectivity between bilateral insula regions and ventral striatum, left insula and middle orbitofrontal cortex (OFC), and right insula projecting to gyrus rectus and medial OFC. Duration of illness predicted connectivity of tracts projecting from the insula to ventral striatum and OFC. Microstructural integrity was lower in Recovered AN in most insula white matter tracts, as was whole-brain FA in parts of the anterior corona radiata, external capsule, and cerebellum (Po0.05, family-wise errorcorrected). This study indicates higher structural white matter connectivity, an estimate of fibers connections, in anorexia after recovery in tracts that connect taste-reward processing regions. Greater connectivity together with less-fiber integrity could indicate altered neural activity between those regions, which could interfere with normal food-reward circuit function. Correlations between connectivity and illness duration suggest that connectivity could be a marker for illness severity. Whether greater connectivity can predict prognosis of the disorder requires further study.

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“…Innocenti, 1986;Innocenti, 1994Innocenti, , 1995Aboitiz et al, 2003). The identification of the topography of these connections is still in progress in humans especially through functional magnetic resonance imaging (Fabri et al, 2011;Phillips and Hopkins, 2012) and diffusion tensor imaging (Hofer and Frahm, 2006;Phillips and Hopkins, 2012). In non-human primates, the majority of brain connectivity data (see datasets established based on the work of Paxinos et al, 2000;Van Essen, 2002;Dubach and Bowden, 2009;Rohlfing et al, 2012;Markov et al, 2014;Calebrese et al, 2015) originate from one hemisphere based on the assumption (though unproven) that lateralization does not play a key role in macaques'.…”

Section: Introductionmentioning

confidence: 99%

Distant heterotopic callosal connections to premotor cortex in non-human primates

et al. 2017

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Abstract-Cortico-cortical connectivity has become a major focus of neuroscience in the last decade but most of the connectivity studies focused on intrahemispheric circuits. Little has been reported about information acquired and processed in the premotor cortex and its functional connection with its homotopic counterpart in the opposite hemisphere via the corpus callosum. In non-human primates (macaques) lateralization is not well documented and its exact role is still unknown. The present study confirms in two macaques the existence of homotopic contralateral projections and completes the picture by further exploring heterotopic (non-motor) callosal projections. This was tested by injecting retrograde tracers in the premotor cortical areas PMv and PMd (targets). Our method consisted of identifying the connections with all the homo-and heterotopic cortical areas located in the contralateral hemisphere. The results showed that PMd and PMv receive multiple low-density labeled inputs from the opposite heterotopic prefrontal, parietal, motor, insular and temporal regions. Such unexpected collection of transcallosal inputs from heterotopic areas suggests that the premotor areas communicate with other modalities through long distance low-density networks which could have important implications in the understanding of sensorimotor and multimodal integration.

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Topographical organization of human corpus callosum: An fMRI mapping study

Cited by 109 publications

References 53 publications

Anatomical location of transcallosal sensorimotor fibers in the human brain: Diffusion tensor tractography study

Anatomical location of transcallosal sensorimotor fibers in the human brain: Diffusion tensor tractography study

Greater Insula White Matter Fiber Connectivity in Women Recovered from Anorexia Nervosa

Distant heterotopic callosal connections to premotor cortex in non-human primates

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