2021
DOI: 10.3390/bios11100395
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Topographical Vacuum Sealing of 3D-Printed Multiplanar Microfluidic Structures

Abstract: We demonstrate a novel way of creating three-dimensional microfluidic channels capable of following complex topographies. To this end, substrates with open channels and different geometries were 3D-printed, and the open channels were consecutively closed with a thermoplastic using a low-resolution vacuum-forming approach. This process allows the sealing of channels that are located on the surface of complex multiplanar topographies, as the thermoplastic aligns with the surface-shape (the macrostructure) of the… Show more

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Cited by 6 publications
(1 citation statement)
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“…Various integration technologies are customized and developed based on specific experimental requirements and necessary adaptability adjustments. When developing systems tailored to particular requirements, researchers must contend with a multitude of challenges and issues, including avoiding leakage issues [25], ensuring pressure stability [29], and maintaining mechanical integrity [30]. This paper mainly introduces the manufacturing, integration methods, substrate materials, and the application of microfluidic technology in biosensors for miniature microfluidic biosensors.…”
Section: Introductionmentioning
confidence: 99%
“…Various integration technologies are customized and developed based on specific experimental requirements and necessary adaptability adjustments. When developing systems tailored to particular requirements, researchers must contend with a multitude of challenges and issues, including avoiding leakage issues [25], ensuring pressure stability [29], and maintaining mechanical integrity [30]. This paper mainly introduces the manufacturing, integration methods, substrate materials, and the application of microfluidic technology in biosensors for miniature microfluidic biosensors.…”
Section: Introductionmentioning
confidence: 99%