We establish the phase diagram of the strongly-interacting Bose-Hubbard model defined on a two-leg ladder geometry in the presence of a homogeneous flux. Our work is motivated by a recent experiment [Atala et al., Nature Phys. 10, 588 (2014)], which studied the same system, in the complementary regime of weak interactions. Based on extensive density matrix renormalization group simulations and a bosonization analysis, we fully explore the parameter space spanned by filling, inter-leg tunneling, and flux. As a main result, we demonstrate the existence of gapless and gapped Meissner and vortex phases, with the gapped states emerging in Mott-insulating regimes. We calculate experimentally accessible observables such as chiral currents and vortex patterns.Introduction. The quantum states of interacting electrons in the presence of spin-orbit coupling and magnetic fields are attracting significant attention in condensed matter physics because of their connection to Quantum Hall physics [1], topological insulators [2-4] and the emergence of unusual excitations in low dimensions [5,6]. Recent progress with quantum gas experiments has led to the realization of artificial gauge fields [7], both in the continuum [8][9][10] and for bosons in optical lattices [11][12][13][14], paving the way for future experiments on the interplay of interactions, dimensionality, and gauge fields in a systematic manner. This has motivated theoretical research into the physics of strongly interacting particles in the presence of abelian and non-abelian gauge fields and various questions such as the Quantum Hall effect with bosons [15][16][17][18][19][20][21][22], unusual quantum magnetism [23][24][25][26], and the emergence of topologically protected phases [27][28][29] have been addressed.