Topotecan–filgrastim combination is an effective regimen for mobilizing peripheral blood stem cells

Yeoh, Allen Eng Juh; Cunningham, J. M.; Yee, Gary C.; Hunt, Daniel; Houston, James; Richardson, Stacye; Stewart, Clinton F.; Houghton, Peter J.; Bowman, Laura C.; Gajjar, Amar

doi:10.1038/sj.bmt.1703202

Cited by 5 publications

(1 citation statement)

References 44 publications

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“…These are encouraging results, but the follow-up is too short as failure can be seen at a median of 36 months or later. There are different methods for mobilizing the PBSCs [39], and evaluation of various regimens, such as topotecan and filgastrim, are under active study. To date, there is not sufficient evidence to pick one method over another.…”

Section: Chemotherapymentioning

confidence: 99%

Primitive neuroectodermal tumors/medulloblastoma

M¹

2002

Curr Neurol Neurosci Rep

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The therapy for medulloblastoma/primitive neuroectodermal tumors of the central nervous system is surgery, followed by combination chemo-radiotherapy. The radiation field is the entire craniospinal axis, which is only avoided when treating infants. The treatment is, therefore, lengthy and toxic. Less aggressive therapy is given to patients who clinically appear to have less evidence of disease. Intensive basic research has begun to identify genetic factors of the disease, but these remain far from clinical application.

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Section: Chemotherapymentioning

confidence: 99%

Primitive neuroectodermal tumors/medulloblastoma

M¹

2002

Curr Neurol Neurosci Rep

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Successful mobilization, harvest and transplant of peripheral blood stem cells using AMD3100 and G‐CSF following high dose craniospinal irradiation for medulloblastoma in a young child

Toledano

Yahel

Cohen

et al. 2009

Pediatric Blood & Cancer

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Contemporary protocols for the treatment of malignant brain tumors such as medulloblastoma (MB) in children, often involve craniospinal irradiation (CSI) at diagnosis followed by serial courses of high dose chemotherapy and autologous hematopoietic stem cell support. Patients often require several pheresis procedures in order to collect sufficient stem cells for this type of treatment, particularly if they have already had CSI. We describe the successful mobilization, collection and subsequent transplant of a 7-year-old female with medulloblastoma after recent CSI using granulocyte colony stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100 after a failed previous mobilization attempt using G-CSF alone.

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