2012
DOI: 10.1534/genetics.111.138305
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TORC2 Signaling Is Antagonized by Protein Phosphatase 2A and the Far Complex in Saccharomyces cerevisiae

Abstract: The target of rapamycin (TOR) kinase, a central regulator of eukaryotic cell growth, exists in two essential, yet distinct, TOR kinase complexes in the budding yeast Saccharomyces cerevisiae: rapamycin-sensitive TORC1 and rapamycin-insensitive TORC2. Lst8, a component of both TOR complexes, is essential for cell viability. However, it is unclear whether the essential function of Lst8 is linked to TORC1, TORC2, or both. To that end, we carried out a genetic screen to isolate lst8 deletion suppressor mutants. He… Show more

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Cited by 41 publications
(65 citation statements)
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“…7B), indicating that the tail-anchor domain of Far9 is required for its ER localization. Recently, we proposed that the Far complex antagonizes TORC2 signaling by showing that a far9⌬ mutation or loss of other Far complex components are able to bypass a tor2 temperature-sensitive (tor2-21) mutation (24). We sought to test whether ER localization of the Far complex is required for its function.…”
Section: Er Localization Of Far9 Is Required For Its Optimal Functionmentioning
confidence: 99%
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“…7B), indicating that the tail-anchor domain of Far9 is required for its ER localization. Recently, we proposed that the Far complex antagonizes TORC2 signaling by showing that a far9⌬ mutation or loss of other Far complex components are able to bypass a tor2 temperature-sensitive (tor2-21) mutation (24). We sought to test whether ER localization of the Far complex is required for its function.…”
Section: Er Localization Of Far9 Is Required For Its Optimal Functionmentioning
confidence: 99%
“…In the budding yeast Saccharomyces cerevisiae, the STRIPAK complex has been reported to mediate pheromone signaling, the TORC2 signaling pathway, and the toxicity due to expression of human caspase-10 in yeast (21)(22)(23)(24). The yeast STRIPAK complex contains Far3, Far7, Far8, Far9, Far10, Far11, Tpd3 (the A scaffolding subunit of PP2A), and Pph21/22 (the two redundant catalytic subunits of PP2A) (22)(23)(24)(25)(26).…”
mentioning
confidence: 99%
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