Tormentoside and Two of its Isomers Obtained from the Rhizomes ofPotentilla erecta

Abstract

Symphytum officinale L. (Boraginaceae; common name: comfrey) grows in Europe and Siberia (1) and is found abundantly in Turkey. Within the family Boraginaceae, the genus Symphytum contains several species which are used in traditional medicine as home remedies for inflammatory, rheumatic, and gastrointestinal diseases (2). The identification of both glycosides was performed by acid and alkaline hydrolysis as well as by comparison of their spectroscopic data (IR, UV, FAB-MS, 1H-NMR, 13C-NMR, 1H-1H 2D-COSY, 13H-1H 2D COSY, DEPT, HMBC and HOHAHA) with those previously reported for these compounds (6-8). Information in detail on the work-up procedure and copies of the original spectra are obtainable from the author of correspondence.

Potentilla—A review of its phytochemical and pharmacological profile

“…Potentilla erecta Stachurski et al (1995) Potentilla anserina Li et al (2003) Potentilla discolor Jang et al (2007) 19-Hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3-methyl ester Potentilla multicaulis Li et al (2007) 19-Hydroxy-1-oxo-2-nor-2,3-secours-12-ene-3,28-dioic acid (3␤,18␣,19␣)-3,28-Dihydroxy-20,28-epoxyursan-24-oic acid 3␤,19␣-Dihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester Potentilla erecta Bilia et al (1994) 2␣,3␤-Dihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester 3␤,19␣-Dihydroxyolean-12-en-28-oic acid ␤-d-glucopyranosyl ester 2␣,3␤,19␣-Trihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester Potentilla anserina Zhao et al (2008) Wolf (1908) listed 302 species and divided them into two sections -Trichocarpae and Gymnocarpae -and many subsections, series and tribes or groups of species (Wolf, 1908;Guillén et al, 2005). The genus Potentilla is well known for its difficulties in identifying species and the frequent synonymies (Nicolè et al, 2007).…”

Tormentillae rhizoma – Review for an Underestimated European Herbal Drug

“…Best investigated are Tormentoside (Rosamultin), a glucopyranosylester, and its aglycon, Tormentic acid. Overall, the fraction of triterpens yields between 0.6-1.7 % [19,20].…”

“…▪ Monomers Pedunculagin [24] Pentadigalloylglucose [14] ▪ Dimers Agrimoniin [25] Laevigatin B [26] Laevigatin F (= Tormentillin) [17] Condensed tannins (proanthocyanidins) [6′,6]-all-trans-bi-(+)-Catechin [6] Procyanidin B1 [9] Procyanidin B2 [9] Procyanidin B5 [9] ▪ Trimers (+)-Catechin- [ Arjunetin [20] Chinovic acid [25] Euscaphic acid 28-O-β-D-glucoside (= Kaji-ichogoside F1) [20] Tormentic acid [19] Tormentoside (= Rosamultin) [20] leased from secretory epithelial cells into saliva and contributes to innate immune responses by catalyzing the oxidation of thiocyanate to antimicrobial hypothiocyanite. An ethanolic extract of Tormentil and some other compounds such as ellagic acid or methyl gallate were found as potent LPO-enzyme-regenerating compounds.…”

Potentilla erecta, tormentil

“…Total 1.7%, euscaphic acid glycoside, tormentic acid glycosides: tormentoside (isomer of rosamultin) and isomers: kajiichigoside F1 & arjunetin (cultivated, Poland) (Stachurski et al 1995).…”