Torque properties of a rat oesophagus for physiological and diabetic conditions

Zeng, Yanjun; Qiao, Yongxia; Yang, Jimin; Gregersen, Hans; Zhang, E.-P.; Xu, Xiao-Hu; Xu, Hong

doi:10.1088/0967-3334/25/5/011

Cited by 3 publications

(5 citation statements)

References 37 publications

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“…Zeng et al. ( 2004b ) looked at how diabetes affects the material behaviour of rodent oesophagi over time. As a treatment for diabetic GI disorder, Liu et al.…”

Section: Review Findingsmentioning

confidence: 99%

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Mechanical experimentation of the gastrointestinal tract: a systematic review

Durcan,

Hossain,

Chagnon

et al. 2023

Biomech Model Mechanobiol

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The gastrointestinal (GI) organs of the human body are responsible for transporting and extracting nutrients from food and drink, as well as excreting solid waste. Biomechanical experimentation of the GI organs provides insight into the mechanisms involved in their normal physiological functions, as well as understanding of how diseases can cause disruption to these. Additionally, experimental findings form the basis of all finite element (FE) modelling of these organs, which have a wide array of applications within medicine and engineering. This systematic review summarises the experimental studies that are currently in the literature (n = 247) and outlines the areas in which experimentation is lacking, highlighting what is still required in order to more fully understand the mechanical behaviour of the GI organs. These include (i) more human data, allowing for more accurate modelling for applications within medicine, (ii) an increase in time-dependent studies, and (iii) more sophisticated in vivo testing methods which allow for both the layer- and direction-dependent characterisation of the GI organs. The findings of this review can also be used to identify experimental data for the readers’ own constitutive or FE modelling as the experimental studies have been grouped in terms of organ (oesophagus, stomach, small intestine, large intestine or rectum), test condition (ex vivo or in vivo), number of directions studied (isotropic or anisotropic), species family (human, porcine, feline etc.), tissue condition (intact wall or layer-dependent) and the type of test performed (biaxial tension, inflation–extension, distension (pressure-diameter), etc.). Furthermore, the studies that investigated the time-dependent (viscoelastic) behaviour of the tissues have been presented.

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“…Zeng et al. ( 2004b ) looked at how diabetes affects the material behaviour of rodent oesophagi over time. As a treatment for diabetic GI disorder, Liu et al.…”

Section: Review Findingsmentioning

confidence: 99%

“…( 2009 ) Rodent Intact wall Torsion Zeng et al. ( 2004b ) Distension (pressure-diameter-length) Gregersen et al. ( 2004 ); Liu et al.…”

Section: Review Findingsmentioning

confidence: 99%

Mechanical experimentation of the gastrointestinal tract: a systematic review

Durcan,

Hossain,

Chagnon

et al. 2023

Biomech Model Mechanobiol

View full text Add to dashboard Cite

show abstract

“…Such a model was previously proposed for capturing the behavior of arteries [49,53], myocardium [54], and epicardium [55], among others. Other studies have considered nonzero stress along the thickness of the tissue [35,42], shear in the θ − z plane [38,39],…”

Section: Phenomenological Modelsmentioning

confidence: 99%

“…Five of the studies were on the small intestine and investigated the hyperelastic behavior of the tissue in diabetic rats [37], active behavior in patients with systemic sclerosis [108], hyperelastic behavior in obstructed guinea pigs [42], hyperelastic behavior in obstructed rats [47], and visco-hyperelastic behavior in patients with Hirschsprung's disease [97]. One study investigated the hyperelastic behavior of the esophagus tissue in diabetic rats [38].…”

Section: Speciesmentioning

confidence: 99%

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Biomechanical Constitutive Modeling of the Gastrointestinal Tissues: Where Are We?

Patel¹,

Gizzi²,

Hashemi³

et al. 2021

Preprint

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The gastrointestinal (GI) tract is a continuous channel through the body that consists of the esophagus, the stomach, the small intestine, the large intestine, and the rectum. Its primary functions are to move the intake of food for digestion before storing and ultimately expulsion of feces from the rectum through the anal sphincter. The mechanical behavior of GI tissues thus plays a crucial role for GI function in health and disease. The mechanical properties are typically characterized by a constitutive biomechanical model, which is a mathematical representation of the relation between load and deformation in a tissue. Hence, validated biomechanical constitutive models are essential to characterize and simulate the mechanical behavior of the GI tract under physiological and pathological conditions. Numerous constitutive models have consequently been proposed over the past three decades, mainly inspired by work done in cardiovascular tissues. Here, a comprehensive review of these constitutive models is provided. This review is limited to studies where a model of the strain energy function is proposed to characterize the stress-strain relation of a GI tissue. Several needs are identified for more advanced modeling of GI biomechanics including: 1) Microstructural models that provide actual structure-function relations; 2) Validation of coupled electro-mechanical models accounting for active muscle contractions; 3) Human data under physiological and pathological conditions to develop and validate models. The findings from this review provide guidelines for using existing constitutive models as well as perspective and directions for future studies aimed at establishing new constitutive models for GI tissues.

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