Torsades de Pointes Associated With Ziprasidone

Heinrich, Thomas; Biblo, Lee A.; Schneider, John

doi:10.1176/appi.psy.47.3.264

Cited by 61 publications

(23 citation statements)

References 24 publications

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“…There were only two cases of TdP in the antipsychotic drug group, both associated with ziprasidone overdose. This is consistent with previous reports that ziprasidone appears to prolong QTc to a greater extent than other antipsychotics, including quetiapine, risperidone, olanzapine and haloperidol [38][39][40][41].…”

Section: Discussionsupporting

confidence: 93%

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Al-Abri

Woodburn

Olson

et al. 2015

Am J Cardiovasc Drugs

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Key PointsThe most commonly involved therapeutic classes of drugs associated with ventricular fibrillation and/or tachycardia (VT/VF) were antidepressants (25 %) and stimulants (25 %).The drugs most commonly associated with torsade de pointes (TdP) were antidepressants (25 %) and methadone (25 %).Drug exposures with the greatest risk of death in association with VT/VF were antidepressant exposure [odds ratio (OR) 1.71] and antiarrhythmic exposure (OR 1.75), but neither association was statistically significant.

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Section: Discussionsupporting

confidence: 93%

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Al-Abri

Woodburn

Olson

et al. 2015

Am J Cardiovasc Drugs

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show abstract

“…Ziprasidone is more likely to cause QT prolongation compared to other agents, with a mean prolongation of 15-20 ms over baseline QT durations at peak plasma concentrations in therapeutic use (3,4,34). Although combined poisonings with ziprasidone and other agents have been linked to TdP, uncomplicated ziprasidone overdose has not yet been described to cause this dysrhythmia (35)(36)(37). Drowsiness is the most common symptom reported in overdose (38).…”

Section: Ziprasidonementioning

confidence: 99%

Toxicology and Overdose of Atypical Antipsychotics

Minns

Clark

2012

The Journal of Emergency Medicine

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“…The mean QTc interval lengthening was 15.9 msec for subjects taking ziprasidone. There is one case report of a patient who experienced QTc prolongation during treatment with ziprasidone associated with an asymptomatic episode of torsades de pointes (Heinrich 2006). During the treatment of this patient, on two occasions, discontinuation of ziprasidone was associated with a shortening of the QTc.…”

Section: Cardiac Adverse Effectsmentioning

confidence: 90%

Ziprasidone in the treatment of mania in bipolar disorder

Nicolson

Nemeroff

2008

NDT

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Abstract:Ziprasidone is an atypical antipsychotic with a unique receptor-binding profi le. Currently, ziprasidone is approved by the US Food and Drug Administration for the acute treatment of psychosis in schizophrenia and mania in bipolar disorder. When compared to certain other atypical antipsychotics, ziprasidone appears to have a relatively benign side effect profi le, especially as regards metabolic effects eg, weight gain, serum lipid elevations and glucose dysregulation. Taken together, these data suggest that ziprasidone may be a fi rst line treatment for patients with bipolar mania. However, ziprasidone is a relatively new medication for which adverse events after long-term use and/or in vulnerable patient populations must be studied. Unstudied areas of particular importance include the effi cacy and safety of ziprasidone in the treatment of bipolar depression and relapse prevention of mania as, well as in the subpopulations of pregnant women, the elderly and pediatric patients. The emergence of mania in patients taking ziprasidone is another topic for further study.

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Torsades de Pointes Associated With Ziprasidone

Cited by 61 publications

References 24 publications

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Toxicology and Overdose of Atypical Antipsychotics

Ziprasidone in the treatment of mania in bipolar disorder

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