Total and HMW Adiponectin is Independently Associated with B-type Natriuretic Peptide and Anemia in Chronic Hemodialysis Patients

Abstract

Objective A number of vasculo-protective roles have been reported for adiponectin. In contrast, higher, rather than lower, plasma adiponectin levels are associated with an increased risk of cardiovascular disease and mortality in patients undergoing hemodialysis (HD). The mechanisms by which high adiponectin levels are associated with adverse outcome are unclear. Methods This study measured the level of total and high molecular weight (HMW) adiponectins in 70 patients with HD patients (age: 65.2±8.6 years, man/woman: 30/40), and examined the association between adiponectins, metabolic and echocardiographic parameters. Results Women had a significantly higher total, HMW levels and HMW to total ratio than men. The levels of total and HMW adiponectin were positively correlated with those of HDL-cholesterol and B-type natriuretic peptide (BNP) levels, and negatively associated with body mass index (BMI), triglyceride, high sensitive-C reactive protein (CRP) and hemoglobin levels. A multiple linear regression analysis showed that HMW adiponectin had an independent association with BMI (β=-0.270, p=0.003), HDL-cholesterol (β= 0.356, p<0.001), hemoglobin (β=-0.180, p=0.034) and BNP (β=0.200, p=0.014) as total did adiponectin. Conclusion Anemia and BNP levels had independent influence on the total and HMW adiponectin levels in chronic HD patients.

Negative Correlation of Serum Adiponectin Levels With Carotid–Femoral Pulse Wave Velocity in Patients Treated With Hemodialysis

“…levels in HD patients (Abe et al, 2012;El-Shafey & Shalan, 2014). BMI, waist circumference, body fat mass, and TG and fasting glucose levels were negatively correlated with fasting serum adiponectin levels among peritoneal dialysis patients in another study (C. H. Wang et al, 2010).…”

“…Metabolic syndromeis a cluster of metabolic abnormalities consisting of central obesity, insulin resistance, hyperglycemia, dyslipidemia, and hypertension (Alberti, Zimmet, & Shaw, 2006). Previous research has shown that plasma adiponectin levels were inversely related to BMI and TG and glucose levels in HD patients (Abe et al, 2012; El-Shafey & Shalan, 2014). BMI, waist circumference, body fat mass, and TG and fasting glucose levels were negatively correlated with fasting serum adiponectin levels among peritoneal dialysis patients in another study (C.…”

Predicting the emergence of anemia — A large cohort study

“…Adiponectin is a cytokine released by adipocytes that has been shown in basic studies to suppress hematopoiesis [26]. Other studies also showed a negative correlation between elevated adiponectin and both low hemoglobin and low triglycerides in patients with coronary artery disease [27], chronic kidney disease [28] and diabetic patients [29,30]. Moreover, adiponectin levels were found to be higher in diabetic women than men [30].…”