TOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS

Pizarro, Isabel; Roman-Silva, D. A.; Solar, Carlos; Gómez, Milagros; Cámara, Carmen; Palacios, María A.

doi:10.4067/s0717-97072012000200027

Cited by 5 publications

(6 citation statements)

References 36 publications

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“…It is becoming increasingly evident that low-level exposure to arsenic may have important cardiovascular effects 12 . A previous work 2,6 demonstrated the already suspicious relation between patients living in high inorganic arsenic contaminated areas, who suffered heart attacks, and the high inorganic arsenic content found in their heart tissues. It is therefore necessary to obtain more direct evidence of the fate of arsenic in cardiovascular tissues.…”

Section: Introductionmentioning

confidence: 97%

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Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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SUMMARYThis study evaluated the total and main arsenic species in chicken heart tissues. The experimental study was carried out using two sets of samples. In the first one, 30-day-old chickens were exposed to sodium arsenate, using spiked drinking water. These chickens grew normally and were killed after fifty days of arsenic exposure. The second sets were edible chickens were nonexposed to sodium arsenate for a parallel study. The total arsenic and arsenic species content in the exposed samples were at least twice those in the normal edible chicken. One important aspect is the capability of the heart tissues to preconcentrate the most toxic species, arsenite, in the exposed chicken. Arsenobetaine was also detected in fat in the non exposed chicken.This study could be a way of establishing similarities and differences with humans exposed to the same As(V) species, to ascertain whether chickens can be used in arsenic metabolism evaluation and the results extrapolated to humans.

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Section: Introductionmentioning

confidence: 97%

“…It is well known that arsenic toxicity depends on its chemical species 2 . The main source of arsenic in the human diet is usually marine food, such as shellfish, marine fish, seaweed, etc.…”

Section: Introductionmentioning

confidence: 99%

Arsenic Status and Speciation in Chicken Heart Tissues

Pizarro

Román

Gómez

et al. 2015

J. Chil. Chem. Soc.

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“…2013). Interestingly, a close relation between As concentration in the heart and coronary thrombosis has been reported in the Antofagasta region of northern Chile (Pizarro et al. 2012).…”

Section: Discussionmentioning

confidence: 70%

Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert

Vicuña

Fernández

Vial

et al. 2019

Genome Biology and Evolution

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Inorganic arsenic (As) is a toxic xenobiotic and carcinogen associated with severe health conditions. The urban population from the Atacama Desert in northern Chile was exposed to extremely high As levels (up to 600 µg/l) in drinking water between 1958 and 1971, leading to increased incidence of urinary bladder cancer (BC), skin cancer, kidney cancer, and coronary thrombosis decades later. Besides, the Andean Native-American ancestors of the Atacama population were previously exposed for millennia to elevated As levels in water (∼120 µg/l) for at least 5,000 years, suggesting adaptation to this selective pressure. Here, we performed two genome-wide selection tests—PBSn1 and an ancestry-enrichment test—in an admixed population from Atacama, to identify adaptation signatures to As exposure acquired before and after admixture with Europeans, respectively. The top second variant selected by PBSn1 was associated with LCE4A-C1orf68, a gene that may be involved in the immune barrier of the epithelium during BC. We performed association tests between the top PBSn1 hits and BC occurrence in our population. The strongest association (P = 0.012) was achieved by the LCE4A-C1orf68 variant. The ancestry-enrichment test detected highly significant signals (P = 1.3 × 10−9) mapping MAK16, a gene with important roles in ribosome biogenesis during the G1 phase of the cell cycle. Our results contribute to a better understanding of the genetic factors involved in adaptation to the pathophysiological consequences of As exposure.

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“…[3,4] In northern Chile a close relation between cardiovascular diseases and arsenic concentration in heart and the saphene vein tissues has been reported. [5] The mechanisms of arsenic toxicity are closely related with its induction of radical oxygen species (ROS) generation and inhibition of antioxidant pathways resulting in oxidative damage. [6] The World Health Organization (WHO) guidelines and the US Environmental Protection Agency (EPA) recommend that the total As concentration in drinking water should be below 10 mg L ¡1 .…”

Section: Introductionmentioning

confidence: 99%

Urinary arsenic speciation profile in ethnic group of the Atacama desert (Chile) exposed to variable arsenic levels in drinking water

Yáñez

Mansilla

Santander

et al. 2014

Journal of Environmental Science and Health, Part A

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Ethnic groups from the Atacama Desert (known as Atacameños) have been exposed to natural arsenic pollution for over 5000 years. This work presents an integral study that characterizes arsenic species in water used for human consumption. It also describes the metabolism and arsenic elimination through urine in a chronically exposed population in northern Chile. In this region, water contained total arsenic concentrations up to 1250 μg L(-1), which was almost exclusively As(V). It is also important that this water was ingested directly from natural water sources without any treatment. The ingested arsenic was extensively methylated. In urine 93% of the arsenic was found as methylated arsenic species, such as monomethylarsonic acid [MMA(V)] and dimethylarsinic acid [DMA(V)]. The original ingested inorganic species [As(V)], represent less than 1% of the total urinary arsenic. Methylation activity among individuals can be assessed by measuring primary [inorganic As/methylated As] and secondary methylation [MMA/DMA] indexes. Both methylation indexes were 0.06, indicating a high biological converting capability of As(V) into MMA and then MMA into DMA, compared with the control population and other arsenic exposed populations previously reported.

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TOTAL AND MAIN As SPECIES PRESENT IN CARDIOVASCULAR TISSUES OF PEOPLE LIVINGIN As CONTAMINATED AREAS

Cited by 5 publications

References 36 publications

Arsenic Status and Speciation in Chicken Heart Tissues

Arsenic Status and Speciation in Chicken Heart Tissues

Adaptation to Extreme Environments in an Admixed Human Population from the Atacama Desert

Urinary arsenic speciation profile in ethnic group of the Atacama desert (Chile) exposed to variable arsenic levels in drinking water

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