1998
DOI: 10.1002/(sici)1097-0045(19980601)35:4<243::aid-pros2>3.0.co;2-h
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Total and regional bone mass and biochemical markers of bone remodeling in metastatic prostate cancer

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Cited by 20 publications
(5 citation statements)
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References 26 publications
(30 reference statements)
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“…Although these studies have provided insight into the mechanisms that generate and maintain bone cancer pain, the tumor cells that were employed were primarily osteolytic or bonedestroying in nature (34)(35)(36). A major question is whether these studies will accurately predict the mechanisms that generate the bone pain driven by tumor cells, such as prostate, that are primarily bone-forming rather than bone-destroying resulting from an upset in the balance between osteoblastic or osteolytic activity in the tumor-bearing femur (37). For this reason, we focused on the ACE-1 canine prostate tumor cells, as when these cells are implanted into the femur of nude mice, significant new ''woven'' bone is formed in local compartments, giving the bone a unique scalloped appearance similar to what is observed in humans with prostate tumor metastases to bone (6).…”
Section: Discussionmentioning
confidence: 99%
“…Although these studies have provided insight into the mechanisms that generate and maintain bone cancer pain, the tumor cells that were employed were primarily osteolytic or bonedestroying in nature (34)(35)(36). A major question is whether these studies will accurately predict the mechanisms that generate the bone pain driven by tumor cells, such as prostate, that are primarily bone-forming rather than bone-destroying resulting from an upset in the balance between osteoblastic or osteolytic activity in the tumor-bearing femur (37). For this reason, we focused on the ACE-1 canine prostate tumor cells, as when these cells are implanted into the femur of nude mice, significant new ''woven'' bone is formed in local compartments, giving the bone a unique scalloped appearance similar to what is observed in humans with prostate tumor metastases to bone (6).…”
Section: Discussionmentioning
confidence: 99%
“…Metastatic prostate cancer cells alter the normal bone remodeling balance involving interactions between osteoblasts, osteoclasts, and constituents of the bone matrix to favor bone formation. Both osteoblastic and osteolytic changes occur during the course of tumor progression as a consequence of significant bone resorption and bone production occurring within the metastatic sites (51,52). Although some components of bone remodeling involving tumor metastases have been identified, including PTHrP and transforming growth factor ␤ (52), the process remains ill-defined.…”
Section: Discussionmentioning
confidence: 99%
“…In a study involving 83 specimens from 70 patients with prostatic cancer (32 with and 38 without bone metastasis), the pyridinoline cross-linked carboxyterminal telopeptide (CTP) level was correlated with the extent of disease score more than PSA and other bone markers [64]. In another study, the level of TRAP (a bone resorption marker) and total regional bone mineral content (BMC) measured in 64 patients (32 patients and 32 controls) was found to be significantly different in the pelvis, legs, and trunk of patients compared to the control [66]. These findings confirmed a corresponding increase in bone resorptive (osteoclastic) activity alongside bone osteoblastic activity during bone metastasis [64,65].…”
Section: The Underlying Molecular Mechanisms In Prostate Cancer Bomentioning
confidence: 99%