“…Bone metastasis can be a painful and debilitating symptom in patients with advanced prostate cancer (Glajchen & Moul, 1996;Heim & Oei, 1993;Revilla et al, 1998;Rico et al, 1996;Sciuto et al, 2002). Additionally, hormone therapy increases the risk of osteoporotic bone fracture (Daniell, 2001;McNamara & Sullivan, 1995;Smith et al, 2001;Townsend, Sanders, Northway, & Graham, 1997).…”