Total and Segmental Colon Transit Time Study in Functional Constipation: Comparison With Healthy Subjects

Bhate, Prasad; Patel, Jatin; Parikh, Pathik; Ingle, Meghraj; Phadke, Anniruddha; Sawant, Prabha

doi:10.14740/gr642w

Cited by 16 publications

(11 citation statements)

References 10 publications

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“…The mean TCTT of healthy controls in our study was 20.9 h; it is even lower in some Indian populations (e.g. 15.4 h 16 in adults and 16.2 h in children 17 ). Interval time of 24 h was used in colonic transit test for populations with mean colonic transit time of about 40 h. So, for populations with only half or less of the mean TCTT of Western populations, it is reasonable to decrease the interval time too.…”

Section: Discussioncontrasting

confidence: 71%

Modified colonic transit test in healthy subjects and constipated patients: A triple‐phase, two‐center prospective study

Jiang

Kong

Chang

et al. 2020

J of Gastro and Hepatol

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Background and Aim: Classic daily-ingestion single-film protocol using radiopaque markers for colonic transit time (CTT) is unsuitable for Chinese patients because of rapid colonic motility. A new modified method needs to be established. Methods: The triple-phase study was performed. In Phase I, the classic protocol was assessed to evaluate its feasibility for Chinese subjects. In Phase II, a modified protocol was performed in two centers on 180 healthy subjects and 90 constipated patients to determine optimal conditions. In Phase III, the simplified protocol was validated on 90 constipated patients. Results: All the subjects of the Phase I expelled more than 95% of the markers during the examination period, which means that the classic protocol is unsuitable for Chinese patients. The 20.9-h mean total CTT for healthy Chinese subjects was much faster than that seen in Western countries. As shown by Phase II, the numbers of subjects went beyond the upper limit were 22 in P1TCTT and 10 in P2TCTT (8.14% vs 3.70%, P = 0.029). The percentage of values fall outside of the measurement range of excretion ratio was around half of our study subjects (45-70%), whereas this percentage was only 3.70% using P2TCTT. The simplified protocol had a diagnostic accuracy for constipation of 0.81, with a sensitivity and specificity of 0.46 and 0.97, respectively. Conclusions: Colon movement in Chinese individuals is significantly faster than that of Western populations. The modified protocol generated in this study is appropriate for diagnosis of constipation in population with rapid colon motility.

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Section: Discussioncontrasting

confidence: 71%

Modified colonic transit test in healthy subjects and constipated patients: A triple‐phase, two‐center prospective study

Jiang

Kong

Chang

et al. 2020

J of Gastro and Hepatol

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“…Retention of ≥ 30 radio-opaque markers at 36 h (sensitivity 90%, specificity 82%) and ≥ 14 markers at 60 h (sensitivity 95%, specificity 100%) was quite accurate to detect slow colon transit and FED as causes for CC [ 116 ]. Two other Indian centers reported similar results using this modified protocol [ 117 , 11 ].…”

Section: Consensus Statementsmentioning

confidence: 55%

Indian consensus on chronic constipation in adults: A joint position statement of the Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology

Ghoshal

Sachdeva

Pratap

et al. 2018

Indian J Gastroenterol

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The Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology developed this evidence-based practice guideline for management of chronic constipation. A modified Delphi process was used to develop this consensus containing 29 statements, which were generated by electronic voting iteration as well as face to face meeting and review of the supporting literature primarily from India. These statements include 9 on epidemiology, clinical presentation, and diagnostic criteria; 8 on pathophysiology; and the remaining 12 on investigations and treatment. When the proportion of those who voted either to accept completely or with minor reservation was 80% or higher, the statement was regarded as accepted. The members of the consensus team believe that this would be useful for teaching, clinical practice, and research on chronic constipation in India and in other countries with similar spectrum of the disorders.

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“…Different populations may have shorter average transit times and require an adaptation of the marker methods shown in Western populations. For example, in a study of functional constipation in Indian patients, the participants were asked to ingest a capsule containing 5 markers at time 0, 12 and 24 h followed by X-ray at 36 h after the first ingestion, showing a colon transit time much shorter than in the Western populations [38] Another version of this technique involves the use of multiple capsules with markers of different geometric shapes. The capsules with markers are taken daily for three days, and abdominal X-rays are performed once or twice (usually 4 days and 7 days after administration).…”

Section: X-ray Radiopaque Markersmentioning

confidence: 99%

Section: X-ray Radiopaque Markersmentioning

confidence: 99%

Imaging Measurement of Whole Gut Transit Time in Paediatric and Adult Functional Gastrointestinal Disorders: A Systematic Review and Narrative Synthesis

et al. 2019

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Background: functional gastrointestinal disorders (FGID) are common conditions in children and adults, often associated with abnormalities of whole gut transit. Currently, transit tests can be performed using several imaging methods, including tracking of radiopaque markers, gamma scintigraphy with the use of radioisotopes, magnetic tracking methods, tracking of movement of wireless motility capsules, and emerging magnetic resonance imaging (MRI) approaches. Objectives: to review recent literature on diagnostic imaging techniques used to investigate whole gut transit in FGIDs. Methods: a systematic review was carried out. The different techniques are described briefly, with particular emphasis on contemporary literature and new developments, particularly in the field of MRI. Conclusions: emerging MRI capsule marker methods are promising new tools to study whole gut transit in FGIDs.Small intestinal bacterial overgrowth (SIBO) is another common disorder of the gastrointestinal tract. It reflects excess presence of bacteria in the small bowel, and recent studies suggest SIBO can be associated with altered gut transit [6].Constipation can be caused by slow transit of chyme within the colon. Different factors can contribute to this, including diet, lifestyle and medications [7]. Constipation can also signal the presence of other underlying disorders such as diabetes, coeliac disease and cancer [8].A recent review estimated the average prevalence of constipation at 16% worldwide [9]. In the United States, the number of hospital emergency visits linked to constipation increased by 41.5% between 2006 and 2011 [10]. Constipation is thought to be twice as common in women than in men [9]. Women at the postpartum stage (several weeks after pregnancy) are often affected by the condition, with up to 25% of women reporting the incidence of constipation [11]. Constipation rates tend to be substantially higher in the elderly population and reach up to 50-75%.Most cases of constipation are caused by one of three general mechanisms: disordered and obstructed defecation caused primarily by impaired rectal evacuation, irritable bowel syndrome with constipation, and slow transit constipation [12]. These mechanisms differ substantially, even though the general symptoms of constipation appear very similar. Proper treatment in each case calls for a patient-specific differential diagnosis. This diagnosis remains challenging and about half of all patients who complain of constipation remain unsatisfied with the treatment they receive [12].Slow transit constipation, a reduced intestine motility caused by abnormalities of the enteric nerves, accounts for 15-30% of all constipated patients, with up to 37% of constipated women affected [13].Functional constipation in childhood is very common. Its prevalence has been estimated to be 14%, forming approximately 3% of all hospital paediatric referrals [14][15][16][17][18]. In the majority of paediatric cases, constipation is not linked to specific clinical disorders but rather caused by changes i...

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Total and Segmental Colon Transit Time Study in Functional Constipation: Comparison With Healthy Subjects

Cited by 16 publications

References 10 publications

Modified colonic transit test in healthy subjects and constipated patients: A triple‐phase, two‐center prospective study

Modified colonic transit test in healthy subjects and constipated patients: A triple‐phase, two‐center prospective study

Indian consensus on chronic constipation in adults: A joint position statement of the Indian Motility and Functional Diseases Association and the Indian Society of Gastroenterology

Imaging Measurement of Whole Gut Transit Time in Paediatric and Adult Functional Gastrointestinal Disorders: A Systematic Review and Narrative Synthesis

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