Total antioxidant response in patients with schizophrenia

Üstündağ, Bilal; Atmaca, Murad; Kirtaş, Özlem; Selek, Sahabettın; Metin, Kerem; Tezcan, Ertan

doi:10.1111/j.1440-1819.2006.01532.x

Cited by 47 publications

(33 citation statements)

References 33 publications

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“…Determination of total antioxidant capacity serves as an indicator for all antioxidants [24,49]. In line with our study, lower plasma TAL values were reported in patients with schizophrenia in the studies conducted using the same method [24,50,51]. In other words, it may be expressed that antioxidant defense mechanisms against oxidative stress may differ according to the individuals and environmental conditions.…”

Section: Discussionsupporting

confidence: 83%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

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Objective: In the present study, we aimed to examine the relationship between the oxidative metabolism with disease severity, sociodemographic, and clinical characteristics in the patients with schizophrenia. Methods: Seventy-one patients with schizophrenia and 76 healthy volunteers were included in the study. Plasma total antioxidant level (TAL) and total oxidant level (TOL) were analyzed, and oxidative stress index (OSI) was calculated.Results: There was a statistically significant increase in TOL and OSI and decrease in TAL in the patients with schizophrenia compared to the controls (p < .05). There were positive, mild, statistically significant correlations between TOL, OSI, and Positive and Negative Syndrome Scale-Total scores (p = .01, p = .01, respectively), Positive and Negative Syndrome ScaleNegative scores (p = .002, p = .001, respectively), Positive and Negative Syndrome Scale Global Psychopathology scores (p = .03, p = .03, respectively), and Clinical Global ImpressionSeverity Scale scores (p = .008, p = .009 respectively). OSI levels were significantly lower in the patients who were on treatment with atypical antipsychotics (AAP) compared to the patients who were on typical antipsychotics (TAP) and combined antipsychotic (CAP) agents (p = .032). Conclusions: Oxidative stress was higher in schizophrenia patients. The increased severity of negative symptoms was in line with the disruption in oxidative balance. Oxidative stress is quite lower in AAP users compared to the TAP and CAP users. One of the mechanisms underlying the fact that AAPs are more effective on negative symptoms than typical agents may be the positive effect on the oxidative stress.ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 83%

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Güneş

Altındağ

Bulut

et al. 2017

Psychiatry and Clinical Psychopharmacology

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“…The total antioxidant plasma capacity is not a simple sum of the various antioxidant substances, but includes a dynamic equilibrium that is influenced by the interactions between different serum antioxidant constituents. The present study demonstrated a significant reduction in plasma TAS of patients with schizophrenia compared to healthy controls, this finding was in agreement with similar study conducted by Ustundag et al 44 The brain is preferentially susceptible to oxidative damage since it is under very high oxygen tension and highly enriched in reactive oxygen species (free radicals), susceptible proteins, lipids and poor DNA repair. 45 …”

Section: Discussionsupporting

confidence: 94%

Status of antioxidant defense and lipid peroxidation in schizophrenics with positive, negative and cognitive symptoms

Ogunro

Eegunranti

Atiba

et al. 2013

Free Radicals and Antioxidants

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a b s t r a c tIntroduction: The etiology of schizophrenic is still remains elusive. In the last few decades, dopamine hyperactivity hypothesis predominates in the research field. Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia. The aim of this study is to elucidate whether oxidative stress may have a pathophysiological role in schizophrenia and in clinical course. Methods: A total of 48 schizophrenic patients of age group 18e55 years (30M: 18F) were recruited. The patients were divided into three groups: 18 subjects with positive symptoms, 14 with negative symptoms and 16 with cognitive symptoms. The control groups consist of 48 healthy individuals that were recruited from general population with similar socio-economic status. Total antioxidant ststus (TAS), erythrocyte malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), glutathione (GSH) and glucose-6-phosphate dehydrogenase (G6PD) were measured using standard methods. Results: Erythrocyte MDA concentration was significantly increased in schizophrenic subjects with positive, negative and cognitive symptoms. Contrarily, the erythrocyte antioxidant enzymes GSH-Px and CAT were significantly reduced among schizophrenic subjects. Erythrocyte GSH and plasma TAS concentrations were also significantly reduced in schizophrenic subjects. Likewise, secondary antioxidant enzymes activity G6PD was significantly reduced (p < 0.01) among schizophrenic subjects. Conclusion: Our finding reveals that maintenance of redox balances within cells is a primary component of homeostasis underlying neuronal survival. Studies are pointing to oxidative stress as a part of the pathology in schizophrenia. Therefore, identifying viable therapeutic strategies to tackle oxidative stress and the resulting physiological disturbances will provide an exciting opportunity for the treatment and ultimately prevention of schizophrenia.

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“…Therefore, studies examining antioxidant parameters in patients with schizophrenia are confl icting. Some studies have shown increased antioxidant levels in patients with schizophrenia (23)(24)(25)(26), while some have shown a decrease (22,27,28), and still some have found no change (29)(30)(31). Our results showed an increase in oxidant levels and no change in antioxidants in patients with schizophrenia.…”

Section: Discussionsupporting

confidence: 33%

Elevated nucleosome level and oxidative stress in schizophrenia patients

Bahçeci¹,

Mh²,

Us³

et al. 2015

BLL

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AIM: The aim of this study was to investigate the effect of oxidative stress on nucleosome levels and its relation with the clinical features in schizophrenia patients. MATERIAL AND METHOD: Thirty schizophrenia patients and 30 healthy controls were enrolled in this study. Patients were diagnosed with schizophrenia according to the 4th edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-IV). The control group consisted of 30 healthy subjects matched to the patients with regard to age and gender and who had no history of any psychiatric disorder. The severity of schizophrenia symptoms in the patients was evaluated using the Positive and Negative Syndrome Scale (PANSS) and the Clinical Global Impression Severity Scale (CGI-S). Physical and neurological examinations were performed in each of the patients and controls. RESULTS: Nucleosome, total oxidant levels and OSI values were higher in schizophrenia patients than in controls (p < 0.05). There was no signifi cant difference in the total antioxidant levels. There was a positive correlation between the nucleosome level and PANSS positive subscale (p = 0.028, r = 0.402). There was a positive correlation between TAS and age (p = 0.025, r = 0.289), PANSS total (p < 0.001, r = 0.604). There was a negative correlation between OSI and PANSS total (p = 0.019, r = -0.427), PANSS positive subscale (p = 0.043, r = -0.372). There was a negative correlation between TOS and PANS total (p = 0.028, r = -0.402). CONCLUSION: In this study we found a correlation between nucleosome level and PANSS positive subscale. To our knowledge, this is the fi rst study that evaluates oxidative stress and nucleosomes released from apoptotic cells together (Tab. 2, Ref. 50). Text in PDF www.elis.sk.

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Total antioxidant response in patients with schizophrenia

Cited by 47 publications

References 33 publications

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Oxidative metabolism may be associated with negative symptoms in schizophrenia

Status of antioxidant defense and lipid peroxidation in schizophrenics with positive, negative and cognitive symptoms

Elevated nucleosome level and oxidative stress in schizophrenia patients

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