Total artificial heart system

Abstract

Heart failure is a ubiquitous condition affecting over 60 million people globally and causes substantial morbidity and mortality. Conventionally, terminal heart failure is treated with guidelinedirected medical therapy and cardiac resynchronization therapy, which unfortunately becomes refractory over time, and necessitates escalation to advanced therapies or heart transplantation. Heart transplantation is the ultimate therapy for medically refractory advanced heart failure. Still, the limited supply of donor hearts (~4000 yearly) has spurred the development of mechanical circulatory support (MCS) strategies for heart failure treatment as bridge-to-decision making, bridge-to-myocardial recovery, bridge-to-orthotopic heart transplantation (BTT), and destination therapy (DT).

Prehabilitation Using a Cardiac Rehabilitation Program for a Patient With a Total Artificial Heart Prior to Heart Transplantation

“…A growing number of studies have recently focused on the total artificial heart (TAH), a pump transplanted in the chest to replace the ventricles and valves of a damaged heart. 1 This device now represents a viable treatment option for numerous patients suffering from end-stage heart failure (HF), particularly as a bridge to heart transplantation (HT). The global prevalence of HF is increasing, 2 and despite significant advances over recent decades in the treatment and prevention of chronic HF, a proportion of patients with endstage HF do not respond well to available treatments.…”