Total blood lymphocyte count as a prognostic factor among unselected inpatients

Tojek, Krzysztof; Banaś, Wioletta; Czerniak, Beata; Kowalczyk, Gabriel; Szukay, Beata; Korzycka-Wilińska, Wanda; Banaszkiewicz, Zbigniew; Budzyński, Jacek

doi:10.1016/j.advms.2020.01.001

Cited by 12 publications

(15 citation statements)

References 41 publications

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“…38 Low TLC levels are associated with an increased risk of in-hospital death and longer LOS in hospitalized patients. 39 In this study, we found that there was no difference in the association between the CONUT score and in-hospital mortality of the AIS patients in the different stroke subgroups. However, a previous study explored the association between malnutrition at admission, as determined by the CONUT score, and poor 3-month prognosis in different stroke subgroups.…”

Section: Discussionmentioning

confidence: 48%

Malnutrition on admission increases the in‐hospital mortality and length of stay in elder adults with acute ischemic stroke

Hao

Xia

et al. 2021

Clinical Laboratory Analysis

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Section: Discussionmentioning

confidence: 48%

Malnutrition on admission increases the in‐hospital mortality and length of stay in elder adults with acute ischemic stroke

Hao

Xia

et al. 2021

Clinical Laboratory Analysis

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“…Low TC levels represent deterioration of nutritional status and exacerbated inflammation in older adult patients ( 32 , 36 , 37 ). A TLC less than 0.8 G/L was associated with the risk of in-hospital death, readmission, and LOS in hospitalized patients ( 38 ). A low TLC was also associated with higher mortality in older adult patients and was a predictor of prognosis ( 39 , 40 ).…”

Section: Discussionmentioning

confidence: 99%

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

et al. 2021

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The controlling nutritional status (CONUT) score assesses nutritional status and is associated with short- and long-term prognoses in some diseases, but the significance of the CONUT score for the prediction of in-hospital mortality in older adults is unknown. The purpose was to determine the importance of the CONUT score for the prediction of in-hospital mortality, short-term complications, length of hospital stay, and hospital costs in older adults. Our retrospective cohort study analyzed data from 11,795 older adult patients from two multicenter cohort studies. We performed receiver operating characteristic curve analysis using in-hospital mortality as the endpoint and determined the appropriate CONUT score cut-off by the Youden index. The patients were divided into two high and low groups according to the CONUT cut-off value, and the differences in clinical characteristics and in-hospital clinical outcomes between the two groups were compared. We compared the accuracy of the CONUT score and other nutrition-related tools in predicting in-hospital mortality by calculating the area under the receiver operating characteristic curve and performed univariate and multivariate analyses of predictors of in-hospital mortality. Among all the patients, 178 (1.5%) patients experienced in-hospital death. The optimal cut-off values was 5.5 for the CONUT score. The high CONUT group had a higher incidence of short-term complications and prolonged hospital stay than the low CONUT group (CONUT score <6), but hospital costs were not significantly higher. The CONUT score had the highest predictive ability for in-hospital mortality among the five nutrition-related parameters compared. Multivariate analysis showed that a high CONUT score (CONUT score ≥ 6) was an independent predictor of in-hospital mortality. In conclusion, the present study demonstrated that the CONUT score could be used to predict in-hospital mortality in older adults.

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“…Although there were some missing data and both the complete case analysis and the multiple imputation analysis were performed, the results were robust. Since TLC and BMI are major nutritional assessment items [7,8,21,25,26], AWT can be defined as a variable indicative of nutritional status. Although the association between AWT and nutritional status has not been fully validated in previous studies, our study has demonstrated the validity of using AWT as a nutritional indicator.…”

Section: Discussionmentioning

confidence: 99%

Nutritional and prognostic significance of abdominal wall thickness measured during percutaneous endoscopic gastrostomy in older individuals with dysphagia

Masaki

Kimura

2021

Clinical Nutrition ESPEN

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Background & aims: The significance of abdominal wall thickness (AWT) for nutritional assessment remains unclear. This study aimed to evaluate the nutritional and prognostic significance of AWT measured during percutaneous endoscopic gastrostomy (PEG) in older patients with dysphagia. Methods: This single-center retrospective cohort study enrolled older adults with dysphagia who underwent PEG for enteral nutrition using the introducer technique between February 2010 and January 2019. We examined the association between AWT measured during PEG and nutritional status items, including body mass index (BMI), serum albumin (Alb), total lymphocyte count (TLC), total cholesterol (TC), hemoglobin (Hb), and C-reactive protein (CRP). The shaft length of the PEG tube inserted, which is an approximation value of the AWT, was used for statistical analysis. Patients were divided into three groups: low-AWT group (shaft length 2.5 cm), medium-AWT group (shaft length 3.0e3.5 cm), and high-AWT group (shaft length !4.0 cm). We performed the KruskaleWallis test and multiple linear regression analysis with multiple imputation. We performed survival analysis using the KaplaneMeier method, log-rank test, and Cox regression analysis. Results: A total of 520 patients were identified: 115, 258, and 147 patients in the low-AWT, medium-AWT, and high-AWT groups, respectively. Higher AWT was significantly associated with higher BMI, Alb, TLC, TC, Hb, and lower CRP levels. Multiple linear regression analysis revealed that BMI and TLC were significant predictors of AWT (BMI: coefficient 1.16E-01, 95% confidence interval [CI], 9.77E-02e1.33E-01, P < 0.001; TLC: coefficient 1.18E-04, 95% CI, 2.72E-05e2.09E-04, P ¼ 0.011). The median survival time was the longest in the high-AWT group (low-AWT, 359 days; medium-AWT, 851 days; high-AWT, 1662 days; P < 0.001). The hazard ratio for the high-AWT group relative to the medium-AWT group was 0.59 (95% CI, 0.41e0.85, P ¼ 0.004), and that relative to the low-AWT group was 0.34 (95% CI, 0.24e0.51, P < 0.001). Conclusions: Higher AWT was associated with better nutritional status and survival. AWT may help assess nutritional status and predict survival in older dysphagic patients with PEG.

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Total blood lymphocyte count as a prognostic factor among unselected inpatients

Cited by 12 publications

References 41 publications

Malnutrition on admission increases the in‐hospital mortality and length of stay in elder adults with acute ischemic stroke

Malnutrition on admission increases the in‐hospital mortality and length of stay in elder adults with acute ischemic stroke

Controlling Nutritional Status Score as a Predictive Marker of In-hospital Mortality in Older Adult Patients

Nutritional and prognostic significance of abdominal wall thickness measured during percutaneous endoscopic gastrostomy in older individuals with dysphagia

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