Total body sodium by whole body neutron activation in the living subject: further evidence for non-exchangeable sodium pool.

Chamberlain, Michael J.; Fremlin, J. H.; Peters, D. K.; Philip, H

doi:10.1136/bmj.2.5605.583

Cited by 23 publications

(5 citation statements)

References 7 publications

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“…Exchangeable and total body sodium were closely correlated, and their mean ratio was 0.89 in patients with essential hypertension, which may be compared with published figures of 0.80 in our preliminary study on eleven hypertensive subjects [I], and 0.82 in three normal subjects [20], 0.73 in five normal subjects [21] and 0.86 in six patients with osteomalacia [3]. In view of the paucity of data for comparison, and since there may be some difference between the methods used, we have no strong evidence for any abnormality in the relationship between total and exchangeable sodium in essential hypertension.…”

Section: Discussionsupporting

confidence: 78%

Whole body elemental composition in patients with essential hypertension

Williams

Boddy

Brown

et al. 1982

Eur J Clin Investigation

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The whole body content of sodium, chlorine and potassium has been measured in 30 patients with essential hypertension, using the techniques of in vivo neutron activation analysis and whole body counting. Total exchangeable sodium and potassium were also measured, and found to be well correlated with the total body amounts of these elements. Comparable measurements on normotensive subjects could not be obtained, but results for both elements were similar to those expected on the basis of published values for healthy normal body composition. Similarly, no abnormality was found in the average body content of the other major elements (chlorine, calcium, phosphorus and nitrogen). We therefore have no evidence that essential hypertension is associated with any abnormality in the mean body content of these elements. However, there was some evidence of a relationship between body sodium and blood pressure in this study group.

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Section: Discussionsupporting

confidence: 78%

Whole body elemental composition in patients with essential hypertension

Williams

Boddy

Brown

et al. 1982

Eur J Clin Investigation

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“…TBNa and Na e were highly correlated in our patients and, generally, were similar to the expected normal values, although there was sug gestive evidence of some interesting deviations. Na e represented 80-3% of TBNa, which compares with earlier values of 82·3% (Chamberlain et al, 1968), 72-7% (Rudd et al, 1972) and 91-6% (Anderson et al, 1972). The technique of measuring concur rently TBNa and Na e allows estimation of nonexchangeable sodium, which may vary in patients with primary hyperaldosteronism (Streeten et al, 1963).…”

Section: Discussionsupporting

confidence: 59%

Concurrent Estimation of Total Body and Exchangeable Body Sodium in Hypertension

et al. 1978

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1. Total-body neutron-activation analysis in vivo was carried out in 11 hypertensive subjects to measure simultaneously the total body content of sodium, chlorine, calcium, phosphorus and nitrogen. 2. There was a highly significant correlation between total body sodium measured by activation analysis and total exchangeable sodium measured by a standard isotope-dilution technique (r = 0.92, P less than 0.001). Exchangeable sodium averaged 80.3% of total body sodium. 3. The measured values of chlorine, calcium, phosphorus and nitrogen were similar to those for healthy subjects reported by others. 4. Activation analysis in vivo appears promising as an additional tool for investigating sodium metabolism in hypertension, as it is the only method available for determining the total body content of this element. The radiation dose (1 rem) is sufficiently low to permit repeated measurements in the same subject.

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“…About 20-30% of total body Na + is non-exchangeable, residing in anhydrous bone matrix. 72, 73, 21, 74 Total body K + diametrically mirrors Na + with about 95% located intracellularly (Table 2). Unlike Na + , however, over 90% of body K + is exchangeable.…”

Section: Cell Volume Homeostasis and Body Na+ And K+ Distributionmentioning

confidence: 99%

Body Fluid Dynamics

Bhave

Neilson²

2011

Journal of the American Society of Nephrology

152

166

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Pioneering investigations conducted over a half century ago on tonicity, transcapillary fluid exchange, and the distribution of water and solute serve as a foundation for understanding the physiology of body fluid spaces. With passage of time, however, some of these concepts have lost their connectivity to more contemporary information. Here we examine the physical forces determining the compartmentalization of body fluid and its movement across capillary and cell membrane barriers, drawing particular attention to the interstitium operating as a dynamic interface for water and solute distribution rather than as a static reservoir. Newer work now supports an evolving model of body fluid dynamics that integrates exchangeable Na+ stores and transcapillary dynamics with advances in interstitial matrix biology.

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Total body sodium by whole body neutron activation in the living subject: further evidence for non-exchangeable sodium pool.

Cited by 23 publications

References 7 publications

Whole body elemental composition in patients with essential hypertension

Whole body elemental composition in patients with essential hypertension

Concurrent Estimation of Total Body and Exchangeable Body Sodium in Hypertension

Body Fluid Dynamics

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