Total energy expenditure and vigorous-intensity physical activity are associated with reduced odds of reclassification among men on active surveillance

Abstract

Total and vigorous PA were inversely associated with odds of reclassification in two active surveillance cohorts. Given the limitations of this study, more robust prospective observational studies involving objective PA measures are warranted to confirm findings.

Post-Diagnostic Dietary and Lifestyle Factors and Prostate Cancer Recurrence, Progression, and Mortality

“…Multiple studies have examined various forms of postdiagnostic physical activity (PA) in relation to PC outcomes (Table 2). Only three of these considered recurrence/ progression outcomes with mixed results [37,40,42]. Two examined different types of PA in the same cohort of 237 Canadian men on active surveillance [37,40].…”

“…Only three of these considered recurrence/ progression outcomes with mixed results [37,40,42]. Two examined different types of PA in the same cohort of 237 Canadian men on active surveillance [37,40]. These studies demonstrated a lower odds of disease reclassification (OR > 92.27 vs < 46.62 : 0.43; CI: 0.21, 0.88; p trend = 0.027) but not risk of progression, with higher MET-hour/week of total PA, as well as lower odds associated with vigorous PA (OR > 0 vs 0 : 0.42; CI: 0.20, 0.85; p = 0.016) [37,40].…”

“…Two examined different types of PA in the same cohort of 237 Canadian men on active surveillance [37,40]. These studies demonstrated a lower odds of disease reclassification (OR > 92.27 vs < 46.62 : 0.43; CI: 0.21, 0.88; p trend = 0.027) but not risk of progression, with higher MET-hour/week of total PA, as well as lower odds associated with vigorous PA (OR > 0 vs 0 : 0.42; CI: 0.20, 0.85; p = 0.016) [37,40]. In contrast, a CaPSURE analysis of 1455 men with localized disease found no association between vigorous PA and risk of PC progression.…”

“…Despite this fact, existing evidence on postdiagnostic modifiable risk factors has been collected almost exclusively in White populations. Characteristics of 33 recently published (2015-2020) studies are shown in Table 1; 13 did not report the racial/ethnic distribution of their study sample [10,19,21,29,32,34,35,37,38,41,[45][46][47]. An additional seven dichotomized race as White/Caucasian vs other (all ≥ 92% White) [4,5,12,18,24,31,39].…”

Reframing How Physical Activity Reduces The Incidence of Clinically-Diagnosed Cancers: Appraising Exercise-Induced Immuno-Modulation As An Integral Mechanism

“…Similarly, recent results from a randomised-controlled trial of 12 weeks high intensity interval training vs. usual care in men undergoing active surveillance for prostate cancer revealed a statistically significant between-group difference in PSA (−1.1 mg/L, P=.04) but the reduction from baseline in the exercise group was within biological variation of PSA (−6.6% ≈ CV 4.8% 2 ) (69). It has also been shown in other studies that physical activity level is associated with lower risk of disease reclassification in men undergoing active surveillance for lowgrade prostate cancer (70,71). Together, using prostate cancer as an example, it appears that physical activity or exercise training does not eliminate or reverse early-stage cancere.g., in this case, those cells overtly producing PSAbut instead may sustain the maintenance of precancers in equilibrium.…”