Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions

Gu, Yuan; Wang, Xinxin; Liu, Fang; Zhang, Jin; Zhang, Xiufang; Liu, Jiping; Li, Sijia; Wang, Decheng; Hong-quan, Guan; Hou, Diandong

doi:10.1016/j.jep.2022.115195

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…A total of 80 plant adaptogens were studied in the above dermatophytes, accounting for 73.39% of the plant adaptogens in Supplementary Table The highest active ingredient compound categories were, in order, ginsenosides and other terpenoids (23), curcumin and other phenolic compounds (15), and baicalin and other flavonoids (11).…”

Section: Whiteningmentioning

confidence: 99%

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Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Liu¹,

Chen²,

Li³

et al. 2023

DDDT

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Background: Adaptogens are a class of medicinal plants that can nonspecifically enhance human resistance. Most of the plant adaptogens have relevant applications in dermatology, but there are still few studies related to their particular action and co-operative mechanisms in topical skin application. Methods: Plant adaptogens related articles and reviews that published between 1999 and 2022 were obtained from the Web of Science Core Collection database. Various bibliographic elements were collected, including the annual number of publications, countries/regions, and keywords. CiteSpace, a scientometric software, was used to conduct bibliometric analyses. Also, the patsnap global patent database was used to analyze the patent situation of plant adaptogens in the field of cosmetics up to 2021. Results: We found that the effects of plant adaptogens on skin diseases mainly involve atopic dermatitis, acne, allergic contact dermatitis, psoriasis, eczema, and androgenetic alopecia, etc. And the effects on skin health mainly involve anti-aging and antiphotoaging, anti-bacterial and anti-fungal, anti-inflammatory, whitening, and anti-hair loss, etc. Also, based on the results of patent analysis, it is found that the effects of plant adaptogens on skin mainly focus on aging retardation. The dermatological effects of plant adaptogens are mainly from Fabaceae Lindl., Araliaceae Juss. and Lamiaceae Martinov., and their mainly efficacy phytochemical components are terpenoids, phenolic compounds and flavonoids. Conclusion:The plant adaptogens can repair the skin barrier and maintain skin homeostasis by regulating the skin HPA-like axis, influencing the oxidative stress pathway to inhibit inflammation, and regulating the extracellular matrix (ECM) components to maintain a dynamic equilibrium, ultimately achieving the treatment of skin diseases and the maintenance of a healthy state.

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Section: Whiteningmentioning

confidence: 99%

“…Hippophae rhamnoides L.)), Curcumin from turmeric (Curcuma longa) and thymoquinone from Nigella sativa L., etc., can inhibit the immune inflammatory response of the skin in patients with atopic dermatitis. [21][22][23] The ginsenoside Rg5 from Panax ginseng C.A. Mey.…”

mentioning

confidence: 99%

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Liu¹,

Chen²,

Li³

et al. 2023

DDDT

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“…The background for this activity seems to be the decreased protein and mRNA expression of p65 NF-κB and p38 MAPK in the liver of mice with AFLD (Zhao et al, 2022). Apart from diminished expressions of NF-κB, ERK, and p38, total flavonoids of HR also decreased concentrations of IL-1β and IL-6 released by HaCaT cells treated by IFN-γ/TNF-α in vitro (Gu et al, 2022). We confirmed that Caco-2 cells had secreted IL-8 mainly in response to IL-1β stimulation (Eckmann et al, 1993).…”

Section: Figurementioning

confidence: 99%

Fruits of Hippophaë rhamnoides in human leukocytes and Caco-2 cell monolayer models—A question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia

Laskowska

Wilczak²,

Skowrońska³

et al. 2022

Front. Pharmacol.

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Preparations from Hippophaë rhamnoides L. (sea buckthorn) have been traditionally used in the treatment of skin and digestive disorders, such as gastritis, gastric and duodenal ulcers, uterine erosions, as well as oral, rectal, and vaginal mucositis, in particular in the Himalayan and Eurasian regions. An influence of an aqueous extract from the fruits of H. rhamnoides (HR) on leakage of lipopolysaccharide (LPS) from Escherichia coli through gut epithelium developed from the human colorectal adenocarcinoma (Caco-2) monolayer in vitro and glucose transporter 2 (GLUT2) translocation were the principal objectives of the study. Additionally, the effect of HR on the production of pro- and anti-inflammatory cytokines (interleukins: IL-8, IL-1β, IL-10, IL-6; tumor necrosis factor: TNF-α) by the Caco-2 cell line, human neutrophils (PMN), and peripheral blood mononuclear cells (PBMC) was evaluated. The concentration of LPS on the apical and basolateral sides of the Caco-2 monolayer was evaluated with a Limulus Amebocyte Lysate (LAL) assay. GLUT2 translocation was evaluated using an immunostaining assay, whereas secretion of cytokines by cell cultures was established with an enzyme-linked immunosorbent (ELISA) assay. HR (500 μg/ml) significantly inhibited LPS leakage through epithelial monolayer in vitro in comparison with non-treated control. The treatment of Caco-2 cells with HR (50–100 μg/ml) showed GLUT2 expression similar to the non-treated control. HR decreased the secretion of most pro-inflammatory cytokines in all tested models. HR might prevent low-grade chronic inflammation caused by metabolic endotoxemia through the prevention of the absorption of LPS and decrease of chemotactic factors released by immune and epithelial cells, which support its use in metabolic disorders in traditional medicine.

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“…Sea buckthorn berry (SBB), the yellow-orange fruit of the sea buckthorn, is rich in vitamins, carotenoids, and flavonoids ( Ciesarová et al, 2020 ) and are used in various food processing applications, including brewing ( Vilas-Franquesa et al, 2020 ; Belcar and Gorzelany, 2022 ). SBB has been shown to exhibit antioxidant, antibacterial, and antiviral effects ( Olas et al, 2016 ; Yue et al, 2017 ; Kurskaya et al, 2022 ) and is expected to have a high therapeutic and medicinal potential ( Suryakumar and Gupta, 2011 ). However, the immunomodulatory effects of SBB have been little studied ( Geetha et al, 2002 ; Żuchowski, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…However, the immunomodulatory effects of SBB have been little studied ( Geetha et al, 2002 ; Żuchowski, 2023 ). In previous studies, many compounds including polyphenols, have been isolated from SBB, with its flavonoid profile primarily comprising isorhamnetin, quercetin, and kaempferol glycosides ( Fang et al, 2013 ; Gu et al, 2022 ). In this study, we evaluated the inhibitory activities of SBB extract and its fractions on the release of chemical mediators from mast cells using cell lines associated with Type-I allergy.…”

Section: Introductionmentioning

confidence: 99%

Effect of Polyphenols in Sea Buckthorn Berry on Chemical Mediator Release from Mast Cells

Qiu,

Zorig,

Sato

et al. 2023

Prev. Nutr. Food Sci.

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Sea buckthorn ( Hippophae rhamnoides L.) is a deciduous shrub of the Elaeagnaceae family and is widely distributed in northern Eurasia. Sea buckthorn berry (SBB) has attracted attention for its use in many health foods, although its physiological function remains unknown. In this study, we investigated the inhibitory effect of SBB extract and its fractions on Type-I allergy using mast cell lines. Among these fractions, SBB fraction with the highest amount of antioxidant polyphenols significantly inhibited the release of chemical mediators such as histamine and leukotriene B 4 (LTB 4 ) from the stimulated mast cells. This fraction also inhibited the influx of calcium ions (Ca 2+ ) and the phosphorylation of tyrosine residues in proteins, including spleen tyrosine kinase, which is associated with signal transduction during the release of chemical mediators. The active SBB fraction contained isorhamnetin as its major flavonol aglycon. Isorhamnetin inhibited histamine and LTB 4 release from the stimulated cells and suppressed intracellular Ca 2+ influx. These results indicate that isorhamnetin is the primary substance responsible for the antiallergic activity in SBB. In conclusion, SBB may alleviate Type-I allergy by inhibiting the release of chemical mediators from mast cells, and polyphenols may contribute to this effect.

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Total flavonoids of sea buckthorn (Hippophae rhamnoides L.) improve MC903-induced atopic dermatitis-like lesions

Cited by 13 publications

References 36 publications

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Bibliometric Study of Adaptogens in Dermatology: Pharmacophylogeny, Phytochemistry, and Pharmacological Mechanisms

Fruits of Hippophaë rhamnoides in human leukocytes and Caco-2 cell monolayer models—A question about their preventive role in lipopolysaccharide leakage and cytokine secretion in endotoxemia

Effect of Polyphenols in Sea Buckthorn Berry on Chemical Mediator Release from Mast Cells

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