Total glossectomy with preservation of the larynx: oncological and functional results

Navach, Valeria; Zurlo, Valeria; Calabrese, Luca; Massaro, Maria; Bruschini, Roberto; Giugliano, Gioacchino; Ansarin, Mohssen; Chiesa, Fausto

doi:10.1016/j.bjoms.2012.07.009

Cited by 25 publications

(26 citation statements)

References 22 publications

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“…However, these results should be considered in the context of the surgical indication (primary treatment vs rescue treatment or recurrence), given the inherent drop of survival in patients undergoing salvage surgery. Considering the high percentage of salvage surgery in our series (83%), our results are similar to those of Sinclair et al, Navach et al, Vega et al, and Gehanno et al (Table ). Additionally, our results are consistent with those of other studies that showed significantly poorer survival rates in branches of salvage surgery after CRT or tumor recurrence (see Table ), in which the frequent occurrence of multicentric foci make it difficult to obtain free resection margins.…”

Section: Discussionsupporting

confidence: 92%

“…These results are supported by the Sinclair et al series, in which PEG dependency reached 70% in total glossectomy with laryngeal preservation group (vs 30% in total glossectomy with laryngectomy group). However, a recent literature review found significant variability in PEG dependence at 12 months after total glossectomy with laryngeal preservation surgery (mean, 24%; range, 0% to 75%; 71% in our series), because of lack of proper function of the reconstructed neotongue. However, these results were generally acceptable for patients who already had severe swallowing impairment before surgery, especially because most had been previously treated (with surgery, radiation, or chemotherapy) for lesions of the oral cavity .…”

Section: Discussioncontrasting

confidence: 55%

“…Although the larynx is preserved, total glossectomy with laryngeal preservation has a severe impact on the patient's quality of life. 7,8 Whereas technically feasible, the associated morbidity makes its indication controversial, and alternative treatments, such as chemoradiotherapy (CRT) may be preferred in order to avoid this mutilating surgery. It is therefore of the utmost importance to compare the oncologic and functional results of both therapeutic strategies.…”

Section: Justification Of the Technique In Relation To Survival And Fmentioning

confidence: 99%

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Indications, reconstructive techniques, and results for total glossectomy

et al. 2016

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Laryngeal preservation in the context of advanced tumors of the tongue without supraglottic invasion carried similar oncologic results to total glossectomy with laryngectomy, but offers a better phonatory function. However, it is usually associated with a higher gastrostomy dependency ratio. A scrupulous selection of candidates is mandatory. © 2016 Wiley Periodicals, Inc. Head Neck 38: E2004-E2010, 2016.

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Section: Discussionsupporting

confidence: 92%

Section: Discussioncontrasting

confidence: 55%

Section: Justification Of the Technique In Relation To Survival And Fmentioning

confidence: 99%

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Indications, reconstructive techniques, and results for total glossectomy

et al. 2016

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“…Nowadays we are trying to assess lingual cancer in very early stages. Conventional hemiglossectomies or total glossectomies require reconstruction of the lingual area so that our patient will regain oral continence, deglutition and prevent aspiration [4,5]. In initial stages tongue neoplasia will have limited resection areas that usually do not require reconstruction of the defect and usually primary closure is possible.…”

Section: Experimental Partmentioning

confidence: 99%

Methylene Blue Test in Assessing Disease Free Margins in Lingual Carcinoma Resection

Hainăroşie¹,

Zainea²,

Hainăroşie³

et al. 2018

Rev. Chim.

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Lingual squamous cell carcinoma is one of the most frequent localization of the oral carcinomas. The tongue neoplasia represents nearly 40% of the oral carcinomas. Recent studies showed an increasing trend of lingual carcinoma in young patients. Several staining tests have been described to early detect the disease. After detection, disease free margins resection will increase the survival rate. This study aims to analyze the methylene blue staining test in achieving disease free resection margins in lingual squamous cell carcinoma.

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“…Both radiation and elective neck achieve control in more than 90% of cases. 52,53 N1 and N2 diseases are usually treated with surgery or combinations of chemotherapy and radiotherapy. N3 adenopathies are unresectable and are treated with palliative concurrent chemoradiotherapy.…”

Section: Treatment Of Regional Lymph Nodesmentioning

confidence: 99%

Oropharyngeal cancer: an emergent disease?

Granados-García

2016

Salud Publica Mex

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ResumenEl cáncer de orofarínge recientemente ha incrementado su incidencia, por lo que ha atraído la atención pública. Como en otras neoplasias malignas de las vías aerodigestivas superiores se atribuye a los efectos carcinogénicos del tabaco y alcohol, sin embargo evidencia reciente señala un incremento substancial atribuible a los efectos del virus del papiloma humano. Mucho se ha avanzado en relación a los conocimientos de los mecanismos moleculares y genéticos implicados en la génesis y progresión de estas neoplasias, lo que ha conducido al desarrollo de nuevas y prometedoras terapias, mas especificas y menos tóxicas, que han prolongado la vida y mejorado su calidad, pero no han logrado incrementar significativamente la proporción de pacientes curados. Si se desea abatir la mortalidad por estas neoplasias es necesario emprender medidas de salud publica dirigidas a su prevención y diagnóstico temprano.Palabras clave: cáncer de cabeza y cuello; cáncer de vías aerodigestivas; cáncer de orofaringe; tabaco; alcohol; virus del papiloma humano AbstractOropharyngeal cancer incidence has recently increased, thereby attracting public attention. Akin to other malignancies of the upper aerodigestive tract, it has been attributed to the carcinogenic effects of tobacco and alcohol use. However, recent evidence shows that a substantial increase in the disease is attributable to the effects of human papillomavirus (HPV). Marked progress has been made in relation to the knowledge of molecular and genetic mechanisms involved in the genesis and progression of these cancers. This has led to the development of new and promising therapies of a more specific and less toxic nature that have prolonged life and improved its quality. However, these therapies have failed to significantly increase the proportion of patients who are cured. To decrease the mortality associated with these neoplasms, it is necessary to adopt public health measures aimed at prevention and early diagnosis.Keywords: head and neck cancer; cancer of the aerodigestive tract; oropharyngeal cancer; tobacco; alcohol; human papillomavirus EpidemiologyIn Mexico, less than 500 oropharyngeal cancer cases occur among 148 000 malignancies diagnosed each year (annual age-adjusted incidence rate of 0.

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Total glossectomy with preservation of the larynx: oncological and functional results

Cited by 25 publications

References 22 publications

Indications, reconstructive techniques, and results for total glossectomy

Indications, reconstructive techniques, and results for total glossectomy

Methylene Blue Test in Assessing Disease Free Margins in Lingual Carcinoma Resection

Oropharyngeal cancer: an emergent disease?

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