Our research has focused on the design, testing, and application of integrated monitoring programs from a multimedia (air, water, soil, biota) systems approach at several types of study sites. The goals of this paper are: 1) to evaluate selected atmospheric, terrestrial, and aquatic parameters at a high-elevation site in Wyoming (USA), and 2) to illustrate the use of two of these parameters in the appraisal of aquatic ecosystem health at a biosphere reserve (People's Republic of China) and in the design of a landscape-scale (over 6500 hectares) study of ecosystem impacts in Pennsylvania (USA). At the Wyoming site, five evaluation criteria were used to assess monitoring parameters: ecosystem conceptual framework, data variability, uncertainty, usability of methods, and cost-effectiveness. Atmospheric concentrations of nitrates and nitric acid, and stream pH scored lowest overall because of high data variability, high uncertainty, and low cost-effectiveness. Tropospheric ozone was ranked intermediate on most criteria but had high costs of equipment and operation. Metals in vegetation (mosses), aquatic macroinvertebrates, and stream alkalinity scored highest; these parameters each reflected an ecosystem conceptual framework (and scored high as indicators of ecosystem health), and they were intermediate in cost-effectiveness. When we applied selected aquatic parameters at another site (China) within a drainage basin perspective, alkalinity and lotic macroinvertebrates indicated that a small river draining a Biosphere Reserve is potentially sensitive to acid deposition but rapid field assessments have not indicated any ecological damage based on limited sampling. These results from Wyoming and China show that alkalinity and macroinvertebrates should prove useful in landscape and watershed studies (Pennsylvania) of acidic (mining) impacts based on the tools of remote sensing, geographic information systems (GIS), and the global positioning system (GPS).