“…Clinically, postoperative morphine consumption at 24 and 48 h was significantly lower in the CoQ10 group when compared to the control and CoQ10 + IPC groups (Median [P25-P75] at 24 h; CoQ10 3.5 [ 1 , 2 , 3 , 4 , 5 , 6 ] vs. placebo 6 [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ] vs. CoQ10 + IPC 9 [6–13.5] mg, p = 0.037) ( Figure 5 A). In accordance with the cumulative morphine dose, the NRS at 24 h was significantly lower in the CoQ10 group when compared to the placebo and the CoQ10 + IPC groups (Median [P25-P75]; CoQ10 2.5 [ 2 , 3 , 4 ] vs. placebo 5.5 [ 3 , 4 , 5 , 6 ] vs. CoQ10 + IPC 5.5 [ 3 , 4 , 5 , 6 ] mg, p = 0.013) ( Figure 5 B). These results indicated that CoQ10 provided preventive analgesia within the first 48 h after TKA.…”