Abstract. A simple reduction scheme using so-called reduced energies E red and reduced cross sections σ red allows the comparison of heavy-ion induced reaction cross sections for a broad range of masses of projectile and target and over a wide energy range. A global behavior has been found for strongly bound projectiles whereas much larger reduced cross sections have been observed for weakly bound and halo projectiles. It has been shown that this simple reduction scheme works also well for α-particle induced reactions on heavy target nuclei, but very recently significant deviations have been seen for α+ 33 S and α+ 23 Na. Motivated by these unexpected discrepancies, the present study analyses α-induced reaction cross sections for targets with masses A ≈ 20 − 50. The study shows that the experimental data for α-induced reactions on nuclei with A ≈ 20 − 50 deviate slightly from the global behavior of reduced cross sections. However, in general the deviations evolve smoothly towards lower masses. The only significant outliers are the recent data for 33 S and 23 Na which are far above the general systematics, and some very old data may indicate that 36 Ar and 40 Ar are below the general trend. As expected, also the doubly-magic 40 Ca nucleus lies slightly below the results for its neighboring nuclei. Overall, the experimental data are nicely reproduced by a statistical model calculation utilizing the simple α-nucleus potential by McFadden and Satchler. Simultaneously with the deviation of reduced cross sections σ red from the general behavior, the outliers 23 Na, 33 S, 36 Ar, and 40 Ar also show significant disagreement between experiment and statistical model calculation.PACS. 25.55.-e 3H-, 3He-, and 4He-induced reactions -24.10.Pa Thermal and statistical models