Total plasma homocysteine correlates in women with gestational diabetes

Idzior−Waluś, Barbara; Cyganek, Katarzyna; Sztefko, Krystyna; Seghieri, Giuseppe; Breschi, Maria Cristina; Waluś-Miarka, Małgorzata; Kawalec, Ewa; Seretny, Marta; Sieradzki, Jacek

doi:10.1007/s00404-008-0571-1

Cited by 39 publications

(44 citation statements)

References 22 publications

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“…In addition, the GDM diagnostic criteria used varied among the studies. Two studies specified using O’Sullivan and Mahan criteria [19, 20], seven studies used Carpenter–Coustan criteria [21-27]; three studies referenced the World Health Organization [28-30], one study referenced the Fourth International Gestational Diabetes Workshop criteria, and four studies did not specify the GDM diagnostic criteria used [31-34]. …”

Section: Resultsmentioning

confidence: 99%

A systematic review of metabolite profiling in gestational diabetes mellitus

2014

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Aims/hypothesis Gestational diabetes mellitus is associated with adverse maternal and fetal outcomes during, as well as subsequent to, pregnancy, including increased risk of type 2 diabetes and cardiovascular disease. Because of the importance of early risk stratification in preventing these complications, improved first-trimester biomarker determination for diagnosing gestational diabetes would enhance our ability to optimise both maternal and fetal health. Metabolomic profiling, the systematic study of small molecule products of biochemical pathways, has shown promise in the identification of key metabolites associated with the pathogenesis of several metabolic diseases, including gestational diabetes. This article provides a systematic review of the current state of research on biomarkers and gestational diabetes and discusses the clinical relevance of metabolomics in the prediction, diagnosis and management of gestational diabetes. Methods We conducted a systematic search of MEDLINE (PubMed) up to the end of February 2014 using the key term combinations of 'metabolomics,' 'metabonomics,' 'nuclear magnetic spectroscopy,' 'mass spectrometry,' 'metabolic profiling' and 'amino acid profile' combined (AND) with 'gestational diabetes'. Additional articles were identified through searching the reference lists from included studies. Quality assessment of included articles was conducted through the use of QUADOMICS. Results This systematic review included 17 articles. The biomarkers most consistently associated with gestational diabetes were asymmetric dimethylarginine and NEFAs. After QUADOMICS analysis, 13 of the 17 included studies were classified as 'high quality'. Conclusions/interpretation Existing metabolomic studies of gestational diabetes present inconsistent findings regarding metabolite profile characteristics. Further studies are needed in larger, more racially/ethnically diverse populations.

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Section: Resultsmentioning

confidence: 99%

A systematic review of metabolite profiling in gestational diabetes mellitus

2014

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“…Hence impaired homocysteine and folate metabolism is associated not only with cardiovascular disease but also with a wide range of common diseases like neural tube defects, congenital birth defects, congenital heart disease, late pregnancy complications, different kinds of neurodegenerative and psychiatric diseases and cancer [17][18][19][20]. Previous studies showed that hyperhomocysteinemia is associated with an increased risk of pregnancy complications like pre-eclampsia and gestational diabetes mellitus [21][22][23][24].…”

Section: Discussionmentioning

confidence: 99%

Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

Özkan

Yardım-Akaydin

Erdem

et al. 2011

Arch Gynecol Obstet

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“…Some researchers found similar homocysteine levels between two groups [30], but in other investigations, a statistically significant difference in homocysteine levels between GDM and NGT group [31,32] has been observed. Tarim et al [32] found a relationship between homocysteine and 50-g GCT.…”

Section: Discussionmentioning

confidence: 91%

Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes

Aktürk

Altınova

Mert

et al. 2010

Endocr

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As shown in the previous studies, asymmetric dimethylarginine (ADMA) is related to endothelial dysfunction, whereas high-sensitive C-reactive protein (hCRP) is the marker of inflammation. In our study, we investigated ADMA, hCRP, and homocysteine concentrations in women with gestational diabetes mellitus (GDM) and normal glucose tolerance (NGT) during late pregnancy. Fifty-four women with GDM and 69 women with NGT between 32 and 39 weeks of gestation were included in this study. ADMA, hCRP, homocysteine, lipid parameters, glycated hemoglobin (HbA1c) levels, insulin, and homeostasis model assessment for insulin resistance (HOMA-IR) were measured. The plasma ADMA concentrations were significantly higher in GDM patients than in NGT subjects (P = 0.03) and the hCRP levels were also significantly increased in GDM group when compared with those in the NGT group (P = 0.008). However, plasma homocysteine levels did not differ between the groups (P = 0.4), while HOMA-IR, insulin, and triglyceride levels were higher in the GDM group than in the NGT group (P = 0.001, 0.002, and 0.02, respectively). The ADMA concentrations in the third trimester were positively correlated with the glucose levels the 50-g glucose challenge test (GCT) during 24-28 weeks in the whole group (r = 0.21, P = 0.02). Our results demonstrate that ADMA and hCRP are elevated in women with GDM during late pregnancy. Further studies are needed to clarify the significance and the underlying mechanisms of the elevated ADMA and hCRP levels in women with GDM.

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Total plasma homocysteine correlates in women with gestational diabetes

Cited by 39 publications

References 22 publications

A systematic review of metabolite profiling in gestational diabetes mellitus

A systematic review of metabolite profiling in gestational diabetes mellitus

Variability of total thiol compounds, oxidative and nitrosative stress in uncomplicated pregnant women and nonpregnant women

Asymmetric dimethylarginine concentrations are elevated in women with gestational diabetes

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