2001
DOI: 10.5271/sjweh.600
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Total plasma protein adducts of allergenic hexahydrophthalic and methylhexahydrophthalic anhydrides as biomarkers of long-term exposure

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Cited by 9 publications
(6 citation statements)
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References 26 publications
(34 reference statements)
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“…To date exposure assessments of OAAs have been based on measurement of air levels of the compounds8 in addition to biological monitoring of metabolites in biological fluids such as urine or plasma 9–12. Assessments of exposure to OAAs have also been made through quantification of adduct formation to protein 13,14. This approach reflects the integrated exposure during the life‐time of the proteins.…”
mentioning
confidence: 99%
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“…To date exposure assessments of OAAs have been based on measurement of air levels of the compounds8 in addition to biological monitoring of metabolites in biological fluids such as urine or plasma 9–12. Assessments of exposure to OAAs have also been made through quantification of adduct formation to protein 13,14. This approach reflects the integrated exposure during the life‐time of the proteins.…”
mentioning
confidence: 99%
“…Different approaches to quantify protein adducts have been made. Measurements have been performed via acid hydrolysis and quantification of the total amount of protein adducts in plasma 14. Also, methods based on analysis of the conjugates between the OAA and the binding amino acid residue have been applied 15,16.…”
mentioning
confidence: 99%
“…However, for a given air exposure, the levels of MHHPA adducts are about three times higher than for HHPA (10). Thus, although the levels of the total plasma protein adducts of MHHPA are higher than those of HHPA, the air exposure levels of the anhydrides are almost the same within the various exposure groups.…”
Section: Discussionmentioning
confidence: 81%
“…The approximate corresponding air levels calculated from the data of Rosqvist et al (10) and the characteristics of the subjects in the various exposure groups for HHPA and MHHPA have been tabulated in table 1.…”
Section: Resultsmentioning
confidence: 99%
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