Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

Bennett, Tristram C.; Matz, Brad M.; Henderson, Ronald D.; Straw, Rodney C.; Liptak, Julius M.; Selmic, Laura E.; Collivignarelli, Francesco; Buracco, Paolo

doi:10.1111/vsu.12768

Cited by 44 publications

(86 citation statements)

References 29 publications

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“…Complications occurring in either the intraoperative or the postoperative period were classified as major or minor. Minor complications were defined as events that were self‐limiting or that resolved with medical management . Major complications were defined as events requiring a surgical revision, resulting in death, or leading to euthanasia …”

Section: Methodsmentioning

confidence: 99%

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

et al. 2019

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Objective: To describe the clinical characteristics, perioperative complications, and outcomes in dogs surgically treated for gastric carcinoma. Study design: Multi-institutional retrospective case series. Animals: Forty client-owned dogs with histologically confirmed gastric carcinoma.Methods: Medical records were reviewed for preoperative diagnostics, surgery, histopathology, postoperative complications, adjuvant chemotherapy, disease progression, and survival. Variables were assessed for associations with outcome by using Cox proportional hazards regression analysis. Results: Surgical treatment included partial gastrectomy (28 dogs), Billroth I (9 dogs), subtotal gastrectomy (2 dogs), and submucosal resection (1 dog). Major postoperative complications occurred in 8 of 40 dogs, including septic peritonitis secondary to dehiscence in 4 dogs. The median progression free interval was 54 days, and the median survival time (MST) was 178 days (range, 1-1902). According to multivariable analysis results, experiencing an intraoperative complication was associated with an increased risk of death (hazard ratio [HR] 3.5, 95% CI 1.1-9.8, P = .005), and administration of adjuvant chemotherapy correlated with an improved survival (HR 0.4, 95% CI 0.2-0.9, P = .03). Conclusion: In this population of dogs, MST exceeded historically reported data, major postoperative complication rates were comparable to established literature, and administration of adjuvant chemotherapy was associated with improved survival.

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Section: Methodsmentioning

confidence: 99%

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

et al. 2019

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“…Early studies report a survival time in affected dogs of only a few days [1,20,23,30]. Treatment options include surgical removal of the tumor by subtotal prostatectomy or complete removal of the gland by total prostatectomy [40,59]. Radio-or chemotherapy protocols are described also for dogs affected by prostatic neoplasia [49].…”

Section: Treatment and Outcomementioning

confidence: 99%

“…Surgical treatment is possible although urinary incontinence is reported as an important post-operative risk, mainly following total prostatectomy [21]. Bennett et al [40] described permanent incontinence in eight out of 23 dogs treated with total prostatectomy. Only two of these incontinent dogs were affected by a prostatic carcinoma, whereas the other six dogs were diagnosed with a transitional cell tumor.…”

Section: Treatment and Outcomementioning

confidence: 99%

“…In this paper [59] none of the animals had metastatic disease at the time of treatment. Bennett et al [40] treated 25 dogs with total prostatectomy ( Table 5). Of these 25 dogs, 15 were diagnosed with a TCC, nine with adenocarcinoma and one dog with undifferentiated carcinoma.…”

Section: Treatment and Outcomementioning

confidence: 99%

“…Nevertheless, the presence of BPH is not a predisposing factor for the development of prostatic neoplasia [42]. Although few studies provide information on the mean or median body weight of dogs diagnosed with prostatic neoplasia, the majority of researchers report a population of mainly medium-to large size dogs [1,21,22,32,40]. Breed predispositions are widely negated, yet dogs of Shetland Sheepdog, Scottish Terrier, Bouvier des Flandres, Dobermann Pinscher, and mixed breeds are mentioned more frequently than other breeds [6,15,23,24].…”

Section: Signalment and Clinical Signsmentioning

confidence: 99%

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Prostatic Neoplasia in the Intact and Castrated Dog: How Dangerous is Castration?

Schrank

Romagnoli

2020

Animals

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Elective gonadectomy in the dog is a topic of interest for clinicians, pet-owners, and society. Although canine prostatic neoplasia (CPN) has a low incidence (0.35%), reports of an increased risk for castrated dogs attract attention and cause concern in pet-owners. Our aim is to provide professionals and non-professionals with a detailed description of this possible side effect of gonadectomy in the dog. The mean age at diagnosis of CPN ranges from 8.5 to 11.2 years. Medium to large size breeds are more frequently affected. Symptoms and findings of non-invasive examinations are not pathognomonic, therefore, cytological or histological examinations are needed for diagnosis. Overall, the incidence of metastasis reaches up to 80%, yet lung metastasis reportedly has no negative impact on median survival time (MST). It has been reported that castrated males have a significantly higher MST than intact males. Differences in inclusion criteria for studied populations make a comparison of studies difficult. Citation of odds ratios without consideration of the context of the reference may result in premature conclusions. We conclude that elective gonadectomy of adult male dogs under six years of age cannot be excluded from the veterinary practice due to concern of causing CPN until clear and strong evidence is available.

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Reproductive System

Thomson¹,

Britt²

2022

Veterinary Surgical Oncology

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Total prostatectomy as a treatment for prostatic carcinoma in 25 dogs

Abstract: Total prostatectomy, combined with adjunct therapies, prolongs survival and lowers complication rates compared to previous reports of dogs with prostatic carcinoma. It should be noted, however, that case selection likely played a significant role in postoperative outcome.

Cited by 44 publications

References 29 publications

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

Perioperative complications and outcome after surgery for treatment of gastric carcinoma in dogs: A Veterinary Society of Surgical Oncology retrospective study of 40 cases (2004–2018)

Prostatic Neoplasia in the Intact and Castrated Dog: How Dangerous is Castration?

Reproductive System

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