Total serum IgE levels in Venezuelan schoolchildren

Abstract

Summary Seventy‐eight disease‐free children were evaluated by PRIST for total serum IgE in order to establish the normal range for this immunoglobulin and assess its utility, in tropical climates, such as Venezuela, as a diagnostic tool for clinical allergy. Seventy‐eight normals were selected from a group of 1053 children, aged 7‐12 years from fourteen schools in Caracas. Exclusion from the normal pool was based on nationality, and on historical, clinical, and/or laboratory evidence of atopic and/or infectious diseases, particularly with parasites. In addition to a routine CBC and differential, the following studies were performed: a search for stool ova and parasites; in vitro (RAST) and in vivo (skin prick) testing for specific IgE to Dermatophagoides pteronyssinus, Aspergillusfumigatus, and ragweed. Measurement of antibodies against influenza A and B, adenovirus A2: and B, cytomegalovirus, parainflucnza 1 and 3, herpes simplex, respiratory syncytial virus, Coxsackie B1 to B6, Mycoptasma pneumoniae and Rolavirus was also carried out. Normal serum IgE levels for disease‐free children in the age group studied ranged from 1.7‐255 u/ml. The highest average level (± 74 u/ml) occurred at the age of 9 years. These values differed significantly from age‐matched control groups of known atopic and helminth‐infected children. Thus, once common causes for elevated IgE levels are eliminated, determination of total serum IgE can be utilized as a valuable tool in diagnosis of clinical allergy in countries with tropical climates.

Vergleich von drei Testsystemen zur quantitativen Gesamt-lgE-Bestimmung bei Patienten mit atopischer Dermatitis (intrinsic und extrinsic atopische Dermatitis)

“…Es wird jedoch von zahlreichen Autoren gerade über diese Schwierigkeit berichtet, bei der Beurteilung der Gesamt-lgE-Konzentration, die Normalwerte festzulegen. Der Serum-lgE-Spiegel wird unter anderem durch das Alter des Patienten [21][22][23], die geographische und rassische Herkunft [22][23][24][25][26], die Jahreszeit [27][28][29], die Ernährungslage [30] sowie Alkoholund Tabakkonsum [31,32] beeinflußt. Atopische Erkrankungen [27,[33][34][35][36][37][38][39] und Parasitenbefall [40,24] können Ursache extrem hoher IgE-Spiegel sein.…”

“…Die Bestimmung von allergenspezifischen IgE-Antikörpern und Gesamt-lgE-Werten stellt seit mehr als25 Jahren einen Eckpfeiler der Allergiediagnostik dar. Bis in die 80er Jahre dominierten auf diesem Gebiet die Rast-Technologien.…”