Total spondylectomy for solitary bone plasmacytoma of the lumbar spine in a young woman: a case report and review of literature

Höh, Nicolas H. von der; Tschoeke, Sven K.; Gulow, Jens; Voelker, Anna; Siebolts, Udo; Heyde, Christoph-Eckhard

doi:10.1007/s00586-013-2922-2

Cited by 11 publications

(13 citation statements)

References 23 publications

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“…6 The median overall survival rate for solitary plasmacytoma of bone varies from 7.5 to 12 years, 7 and vertebral involvement has been reported as a poor prognostic factor compared with other sites of skeletal involvement. 8 The serum and urinalysis laboratory findings that characterize multiple myeloma are almost never present in a patient with a solitary plasmacytoma. Dissemination from a solitary plasmacytoma to multiple myeloma occurs within 5 years of initial presentation up to 80% of the time.…”

Section: Discussionmentioning

confidence: 99%

Plasmacytoma of the Cervical Spine: A Case Study

Pashayan

Cavanaugh

Warshel

et al. 2017

Journal of Chiropractic Medicine

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Objective: The purpose of this case study is to describe the presentation of a patient with plasmacytoma. Clinical Features: A 49-year-old man presented with progressive neck pain, stiffness, and dysphagia to a chiropractic office. A radiograph indicated a plasmacytoma at C3 vertebral body. The lesion was expansile and caused a mass effect anteriorly on the esophagus and posteriorly on the spinal cord. Neurologic compromise was noted with fasciculations and hypesthesia in the right forearm. The patient was referred to a neurosurgeon. Intervention and Outcome: Surgical resection of the tumor was performed with a vertebral body spacer and surrounding titanium cage. Bony fusion was initiated by inserting bone grafts from the iliac crests into the titanium cage. Additional laboratory analysis and advanced imaging confirmed that the plasmacytoma had progressed to multiple myeloma and radiation and chemotherapy were also necessary. Conclusion: A chiropractor recognized a large, expansile plasmacytoma in the C3 vertebral body and referred the patient for surgical care. This case suggests that all practitioners of manual medicine should provide a careful analysis of the patient's clinical presentation and, if clinically warranted, radiographic examination to determine neck or back pain is due to an underlying malignant condition. (J Chiropr Med 2017;16:170-174)

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Section: Discussionmentioning

confidence: 99%

Plasmacytoma of the Cervical Spine: A Case Study

Pashayan

Cavanaugh

Warshel

et al. 2017

Journal of Chiropractic Medicine

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“…SBP can be diagnosed by biopsy demonstrating monoclonal plasma cell infiltration of a single lesion. The median age at diagnosis of SBP is 10 years younger than that of MM[ 3 ]. To date, the treatment choices of tumors in the upper cervical spine are controversial, especially in terms of the surgical approaches, extent and reconstruction.…”

Section: Discussionmentioning

confidence: 99%

“…SBP is a rare diagnosis for which the primary treatment is local radiotherapy. The exact role of surgery for SBP remains unclear[ 3 - 5 ]. Although MM is a common disease when compared to other plasma cell neoplasms, SBP in the vertebral body is a rare condition with little published literature[ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The exact role of surgery for SBP remains unclear[ 3 - 5 ]. Although MM is a common disease when compared to other plasma cell neoplasms, SBP in the vertebral body is a rare condition with little published literature[ 3 ]. Meanwhile, the upper cervical spine (C1/2) has a unique function and biomechanical and anatomical characteristics.…”

Section: Introductionmentioning

confidence: 99%

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Solitary bone plasmacytoma of the upper cervical spine: A case report

Jiang

2021

WJCC

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BACKGROUND Solitary bone plasmacytoma (SBP) of the upper cervical spine is a rare diagnosis. The exact role of surgery for SBP remains unclear. CASE SUMMARY We present the first case of SBP of the C2. A 69-year-old Chinese woman presented with severe neck pain and limitation of rotative activity for 2 mo. She underwent anterior one-stage debridement combined with cement augmentation in the C2 to reconstruct stability of the spine. The patient did not receive postoperative radiotherapy. She now remains disease free with no neck pain or neurological deficit after follow-up of 3 years. CONCLUSION Anterior one-stage debridement combined with cement augmentation of the upper cervical spine may be an alternative treatment for SBP.

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“…Metastatic disease of the cervical spine is associated with a poorer prognosis than the thoracic or lumbar spine, in addition to surgery in this region having a higher morbidity . The exact role of surgery for spinal MM remains unclear . Age and subtype affect survivorship and skeletal‐related events respectively .…”

Section: Introductionmentioning

confidence: 99%

Managing the cervical spine in multiple myeloma patients

Cawley

Butler

Benton

et al. 2018

Hematological Oncology

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Discuss the relevant literature on surgical and nonsurgical treatments for multiple myeloma (MM) and their complementary effects on overall treatment. Existing surgical algorithms designed for neoplasia of the spine may not suit the management of spinal myeloma. Less than a fifth of metastatic, including myelomatous lesions, occur in the cervical spine but have a poorer prognosis and surgery in this area carries a higher morbidity. With the advances of chemotherapy, early access to radiotherapy, early orthosis management, and high definition imaging, including CT and MRI, surgical indications in MM have changed. Medical decompression (or oncolysis), including in the presence of neurological deficit and orthotic stabilization, are proving viable nonsurgical options to manage MM. A key to decision making is the assessment and monitoring of biomechanical spinal stability as part of a multidisciplinary approach.

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Total spondylectomy for solitary bone plasmacytoma of the lumbar spine in a young woman: a case report and review of literature

Cited by 11 publications

References 23 publications

Plasmacytoma of the Cervical Spine: A Case Study

Plasmacytoma of the Cervical Spine: A Case Study

Solitary bone plasmacytoma of the upper cervical spine: A case report

Managing the cervical spine in multiple myeloma patients

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