Total surface-active phospholipid/sphingomyelin ratio as an index of fetal lung maturity.

Dohnal, J C; Bowie, Lemuel J.

doi:10.1093/clinchem/27.11.1834

Cited by 4 publications

(1 citation statement)

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“…Five studies calculated the L/S ratio as the ration from lecithin to sphyngomyelin (Table 1), whereas one study calculated the L/S ratio from lecithin and phosphatidylglycerol and phosphatidylinositol and phosphatidylethanolamine, compared with sphingomyelin 11 . The latter method has been described by Dohnal and Bowie 17 . To assess the lamellar body count (Table 1), in all studies the resistive‐pulse counting technique was used.…”

Section: Resultsmentioning

confidence: 99%

The accuracy of lamellar body count and lecithin/sphingomyelin ratio in the prediction of neonatal respiratory distress syndrome: a meta‐analysis

Wijnberger¹,

Huisjes²,

Voorbij³

et al. 2001

BJOG

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Objective To compare the performance of the lecithin/sphingomyelin ratio and the lamellar body count in the prediction of neonatal respiratory distress syndrome. Design Meta-analysis.Sample Six studies reporting on the performance of both the lecithin/sphingomyelin ratio and the lamellar body count published between January 1966 and August 1999.Methods We performed a computerised MEDLINE search to identify articles published on the subject. For the six selected studies, prevalence of respiratory distress syndrome and sensitivity and speci®city of the tests in the prediction of respiratory distress syndrome were calculated, and overall performance was assessed by constructing summary receiver±operating characteristic curves. Results The constructed summary receiver±operating characteristic curves showed the lamellar body count to perform slightly better than the lecithin/sphingomyelin ratio in the prediction of respiratory distress syndrome (P 0.13).Conclusions Since the lamellar body count can be performed quickly and since it is less expensive than the lecithin/sphingomyelin ratio, we recommend the former as the test of ®rst choice in the assessment of fetal lung maturity.

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Section: Resultsmentioning

confidence: 99%

The accuracy of lamellar body count and lecithin/sphingomyelin ratio in the prediction of neonatal respiratory distress syndrome: a meta‐analysis

Wijnberger¹,

Huisjes²,

Voorbij³

et al. 2001

BJOG

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Amniotic Fluid Lamellar Body Count: A Rapid and Reliable Fetal Lung Maturity Test

Dalence

Bowie

Dohnal

et al. 1995

Obstetrics &Amp; Gynecology

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The lamellar body count compares favorably with traditional phospholipid testing in the prediction of fetal lung maturity. Phospholipid analysis is not needed with lamellar body counts greater than 30,000/microL or less than 10,000/microL, but may be of benefit for values in the intermediate risk range. Advantages of this test include speed, objectivity, small sample volume required, and universal availability of instrumentation.

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New analytical approaches in clinical chemistry

Crawhall¹,

Purdy²

1982

TrAC Trends in Analytical Chemistry

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Total surface-active phospholipid/sphingomyelin ratio as an index of fetal lung maturity.

Cited by 4 publications

References 0 publications

The accuracy of lamellar body count and lecithin/sphingomyelin ratio in the prediction of neonatal respiratory distress syndrome: a meta‐analysis

The accuracy of lamellar body count and lecithin/sphingomyelin ratio in the prediction of neonatal respiratory distress syndrome: a meta‐analysis

Amniotic Fluid Lamellar Body Count: A Rapid and Reliable Fetal Lung Maturity Test

New analytical approaches in clinical chemistry

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