Total syntheses and configuration assignments of JBIR-04 and unantimycin A

Abstract

First total syntheses of JBIR-04 and unantimycin A have been achieved. Comparison of our spectroscopic data with those reported for natural samples verified the structure of the natural products; (2S,4S,6S,7R,9S,28S) configuration was thus assigned via total synthesis.

Total Syntheses and Configuration Assignments of JBIR-06 and Related Depsipeptides

“…The absolute configuration of the threonine moiety of 1 was elucidated to be L by Marfey’s method; however, the other three stereogenic centers were not determined. During our studies on the total syntheses of antimycin-type antibiotics, we focused on the total synthesis and stereochemical elucidation of 1 . Recently, Awakawa and Abe et al have reported the production of JBIR-06 and related ring-expansion compounds with reprogramming of the antimycin NRPS (nonribosomal peptide synthase)/PKS (polyketide synthase) assembly line .…”