Total Synthesis of Biologically Active Natural Products

Roush, William

doi:10.1021/ja8028813

Cited by 15 publications

(9 citation statements)

References 21 publications

(24 reference statements)

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“…Natural products have always served as an inspiration for the development of new pharmaceuticals, pesticides and herbicides or dyesand total synthesis is oen the only way to provide access to such products in sufficient quantities for extensive investigation, let alone commercial endeavours. [4][5][6] Therefore, total synthesis, natural product isolation and structure elucidation have close ties. The search for new compounds with attractive biological activities or chemical structures has fueled the development of new analytical methods and synthetic chemists were never shy to tackle any attractive target molecule virtually regardless of its size.…”

Section: Total Synthesisa Driving Force For New Developmentsmentioning

confidence: 99%

Making natural products from renewable feedstocks: back to the roots?

2020

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Section: Total Synthesisa Driving Force For New Developmentsmentioning

confidence: 99%

Making natural products from renewable feedstocks: back to the roots?

2020

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“…Next, a regio-and stereoselective dihydroxylation of 166 with OsO 4 , followed by a DBU-promoted nucleophilic aliphatic substitution, afforded oxetane 167. Finally, an additional seven-step protocol completed the total synthesis of (À)-taxol (1).…”

Section: Danishefsky's Syntheses Of (G)-phomoidrides (2000)mentioning

confidence: 99%

“…Chemical synthesis is unique among the physical sciences owing the perceptiveness and creativity involved. 1 This is especially true of research on natural product synthesis, which remains among the most exciting and dynamic research areas. In addition to original structural identification, continued interest in the synthesis of natural products has been fueled by the recognition that natural products remain an important source of new drugs and continue to inspire new approaches to problems in organic chemistry.…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis of Natural Products Containing a Bridgehead Double Bond

Liu

et al. 2020

Chem

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Natural products with a bridgehead double bond, such as taxol and CP molecules, have long attracted considerable attention from chemists because of their promising bioactivity and structural complexity, with the high ring-strain energy in the ring systems representing a formidable synthetic challenge. Herein, strategies for the total synthesis of such complex natural products are reviewed for the first time by using 26 representative studies. Methods for constructing the bridged ring system and bridgehead double bond have been emphasized, including syntheses of the same natural product by different research groups using different strategies, to showcase the diversity of thought and creativity in this area. The total synthesis of these natural products not only provides precious bioactive substances and promising candidates for drug discovery but also has stimulated incredible advances in the development of new strategies and synthetic methods.

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“…The total synthesis of complex natural products still remains among the most exciting and dynamic areas of research, with representative publications in this area routinely ranking among the most-read in every chemistry-focused journal. Three excellent prior summaries of fantastic accomplishments in this area have appeared in 2008, 2013, and 2014, with the creation of virtual issues highlighting many representative publications from those time periods. In all of the editorials accompanying those expertly curated virtual issues, strong cases were made for why total synthesis continues to be an important and topical area of investigation.…”

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confidence: 99%