“…This patch often of vein or serosa origin, although synthetic patches have also been used. A significant number of modifications of the original protocol have been proposed, aiming in higher incidence of AAA induction with predictable results (Huynh et al 2007, Kajimoto et al 2008, Lerouge et al 2004, Murphy et al 2007, Scholz et al 2008, Mucke et al 2008, Allaire et al 2002, Soulez et al 2007. Despite many similarities existing between surgically induced AAA in animal models and human AAA development, such as main AAA morphological characteristics, there are noticeable differences, such as the increase of SMC and aortic fibroblasts in some animal models that come into contradictions with the human AAA development process (Molacek et al 2009, Scholz et al 2008, Mucke et al 2008.…”