(+)−Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis

Constantine, G.H.; Karchesy, Joseph J.; Franzblau, Scott G.; LaFleur, Lawrence E.

doi:10.1016/s0367-326x(01)00272-6

Cited by 29 publications

(25 citation statements)

References 7 publications

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“…Its isolation from the roots has never been reported. Totarol is a known antimycobacterial agent with activity against Mycobac- terium tuberculosis H 37 Rv and some NTM species (Constantine et al, 2001;Mossa et al, 2004;Muhammad et al, 1995). Its activity against Mycobacterium aurum, Mycobacterium fortuitum and Mycobacterium phlei is reported here for the first time.…”

Section: Resultsmentioning

confidence: 78%

“…This is, however, the first report of its isolation from the roots and the first report of its antimycobacterial activity. Totarol has previously been isolated from Juniperus procera and other plants within the Cuppressaceae family (Constantine et al, 2001;Iwamoto et al, 2001;Muhammad et al, 1995;Sharp et al, 2001). It has recently been detected in some commercial gin samples aromatised with Juniperus communis berries (Vichi et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Gordien

Gray

Franzblau

et al. 2009

Journal of Ethnopharmacology

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Section: Resultsmentioning

confidence: 78%

Section: Resultsmentioning

confidence: 99%

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Gordien

Gray

Franzblau

et al. 2009

Journal of Ethnopharmacology

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“…Totarol (1), ferruginol (2) and ferulenol acetate (8), on the other hand, were inactive at this concentration. However, totarol (1), with an MIC at 16 µg/mL, and dehydroabietylguanidine were reported to be active against M. tuberculosis H37Rv (Constantine et al, 2001;San Feliciano et al, 1993), while plumbagin also exhibited in vitro tuberculostatic activity, but was inactive against drug-resistant M.…”

Section: Resultsmentioning

confidence: 99%

Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide

Mossa

El‐Feraly

Muhammad

2004

Phytotherapy Research

102

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The synergistic activity of antimycobacterial constituents from Saudi plants was evaluated in combination with isonicotinic acid hydrazide (INH) against four atypical organisms, namely, Mycobacterium intracellulare, M. smegmatis, M. xenopei and M. chelonei. The potency of INH was increased four-fold, using an in vitro checkerboard method, against each mycobacteria when tested with a subtoxic concentration of the totarol, isolated from J. procera. The MIC values of totarol, ferulenol (from Ferula communis) and plumbagin (from Plumbago zeylanica) were thus lowered from 1.25-2.5 to 0.15-0.3 microg/mL due to synergism with INH. When tested against the resistant strain of M. tuberculosis H37Rv, plumbagin and 7beta-hydroxyabieta-8,13-dien-11,12-dione exhibited inhibitory activity at <12.5 microg/mL, while others were inactive at this concentration.

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“…Since it has been shown to inhibit the proliferation of several pathogenic Gram-positive bacteria such as Staphylococcus aureus and Mtb [41–42], Jaiswal et al examined the effect of totarol on the assembly dynamics of Mtb FtsZ in vitro [43]. In the preliminary study they found that totarol increased the length of B. subtilis cells by several fold, indicating its inhibitory activity against cell division.…”

Section: Mtb Ftsz Inhibitorsmentioning

confidence: 99%

Discovery of Anti-TB Agents that Target the Cell-Division Protein FtsZ

et al. 2010

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The emergence of multidrug-resistant Mycobacterium tuberculosis strains has made many of the currently available anti-tuberculosis (TB) drugs ineffective. Accordingly, there is a pressing need to identify new drug targets. Filamentous temperature-sensitive protein Z (FtsZ), a bacterial tubulin homologue, is an essential cell-division protein that polymerizes in a GTP-dependent manner, forming a highly dynamic cytokinetic ring, designated as the Z ring, at the septum site. Other cell-division proteins are recruited to the Z ring and, upon resolution of the septum, two daughter cells are produced. Since inactivation of FtsZ or alteration of FtsZ assembly results in the inhibition of Z-ring and septum formation, FtsZ is a very promising target for novel antimicrobial drug development. This review describes the function and dynamic behaviors of FtsZ and the recent development of FtsZ inhibitors as potential anti-TB agents.

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(+)−Totarol from Chamaecyparis nootkatensis and activity against Mycobacterium tuberculosis

Cited by 29 publications

References 7 publications

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Antimycobacterial terpenoids from Juniperus communis L. (Cuppressaceae)

Antimycobacterial constituents from Juniperus procera, Ferula communis and Plumbago zeylanica and their in vitro synergistic activity with isonicotinic acid hydrazide

Discovery of Anti-TB Agents that Target the Cell-Division Protein FtsZ

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