Touch stimulated pulse generation in biomimetic single-layer graphene

Sul, Onejae; Chun, Hyun-Suk; Choi, Eunseok; Choi, JungBong; Cho, Kyeongwon; Jang, Dong-Pyo; Chun, Sungwoo; Park, Wanjun; Lee, Seung‐Beck

doi:10.1039/c5nr07115a

Cited by 7 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Comparison among different strategies of stimulation of PNS to evoke tactile percepts. Parameters that have been considered are: i) number of subjects (S) and implant duration; ii) type of implanted electrode, number of channels, nerve target; iii) impedance measurement; iv) type of stimulation pattern; v) threshold charge/current over time; vi) …”

Section: Implantable Neuroprostheses In Clinical Applicationsmentioning

confidence: 99%

See 1 more Smart Citation

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Cutrone

Micera

2019

Adv Healthcare Materials

View full text Add to dashboard Cite

functions of nervous system when damages occur. Moreover, in case of physical impairments, the use of artificial tactile sensors is also paramount to ensure the possibility to restore the sense of touch to the patient. Bioinspiration from human natural touch could help in the release of enhanced tactile sensors to be used in neuroprosthetics. Technological and biological advancements brought serious improvements in the quality of these devices, such as miniaturization and increased biocompatibility. This article reviews the essential design criteria, working principles, materials, and technical considerations on neural interfaces and tactile sensors; their clinical application in neuroprosthetics and their future progress toward optimized solutions. Neural InterfacesA neural interface device (NID) is an implantable tool that aims at restoring nervous system functions in case of impairments or communicates with external components (e.g., limb prostheses); its main objective is to record neural signal from a small group of axons/cells or to stimulate a selected area of the nervous system. The clinical potentialities of NIDs range from their applications in central nervous system (CNS) for treating epilepsy seizures, mitigating Parkinson's disease; in peripheral nervous system (PNS) for controlling limb prostheses in amputees and restore sensory feedback; in autonomous nervous system such as vagus nerve to treat drug-resistant epilepsy and chronic depression to finally auditory and vision systems to restore the perception of specific sounds and phosphenes. An ideal NID should be biocompatible, highly selective, low invasive and stable over long time. If intended for clinical applications, the functionality of a NID should be reliable and should last decades. Considering the different implantation sites of interest of the device, various solutions have been proposed to optimize the communication between the NID and the surrounding environment. Figure 1 highlights the main applications of most common used NIDs in neuroprosthetics. With a special focus on implantable neuroprostheses and motor system, this paragraph will portray the design criteria, the materials and technical considerations heretofore used for the development of diverse types of NID used in CNS and PNS.Neuroprosthetics and neuromodulation represent a promising field for several related applications in the central and peripheral nervous system, such as the treatment of neurological disorders, the control of external robotic devices, and the restoration of lost tactile functions. These actions are allowed by the neural interface, a miniaturized implantable device that most commonly exploits electrical energy to fulfill these operations. A neural interface must be biocompatible, stable over time, low invasive, and highly selective; the challenge is to develop a safe, compact, and reliable tool for clinical applications. In case of anatomical impairments, neuroprosthetics is bound to the need of exploring the surrounding environment by fast-responsive and ...

show abstract

Section: Implantable Neuroprostheses In Clinical Applicationsmentioning

confidence: 99%

“…Sul et al has proposed a graphene‐based pressure sensor that generates artificial action potentials upon pressurization, without using any spike neuron model. Nonetheless further developments are required to mimic neuron spiking behavior that is much more complex (e.g., tonic and phasic spiking/bursting).…”

Section: Future Of Neuroprostheticsmentioning

confidence: 99%

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Cutrone

Micera

2019

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…In recent years, some people who have impaired somatosensation caused by neuropathy or amputation have been treated using a prosthesis with neural stimulation to restore sensory functions that originate from the skin. [1][2][3] Modern prosthetic devices aim to decode the textures of a touched surface and encode that information through electrical neurostimulation. [3][4][5][6] Studies have demonstrate that pulse patterns of electrical stimulation on the afferent nerve are related to the subjective differentiation of sensations.…”

Section: Introductionmentioning

confidence: 99%

Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice

Cho

Jang

Kim

et al. 2017

Int. J. Precis. Eng. Manuf.

Self Cite

View full text Add to dashboard Cite

Some people with amputated limbs can benefit from neural prosthetics to restore tactile sensation through electrical stimulation of the afferent nerve. The temporal spike train pattern generated in healthy subject's nerve by various types of somatosensation could provide key information to closely mimic natural sensations using electrical stimulation. However, the temporal firing patterns of peripheral sensory fibers have not been well understood yet. To interpret somatosensory spike trains, we performed ex vivo singlefiber recordings from the saphenous nerve in isolated skin-nerve preparations from mice. Some mechanically sensitive primary afferent C-fibers could also be activated by hot, cold, and itching stimuli, and we observed stimulus-specific firing patterns. These temporal patterns of the C-fibers for chemical stimuli were analyzed using a computational model based on quadruplets of spikes, which we classified into three groups of responses, i.e., capsaicin (hot), allyl-isothiocyanate (cold), and α-methyl-serotonin (itching). Each group of responses to the chemical stimuli was different from that evoked by mechanical stimuli. Therefore, these findings indicate that nontactile somatosensation can be decoded and used as input to a computerized system. Our quadruplet approach to the temporal patterns of spike trains contributes valuable insight to the identification of temporal profiles of other biological conditions.

show abstract

“…The ambipolar band structure of graphene is a unique characteristic that is a source for developing many novel electronic devices [1][2][3][4][5][6]. In a graphene-based field-effect transistor, a gate voltage sweep can generate a V-shaped current, when the sweep range includes the Dirac voltage.…”

Section: Introductionmentioning

confidence: 99%

Selective Dirac voltage engineering of individual graphene field-effect transistors for digital inverter and frequency multiplier integrations

et al. 2017

Self Cite

View full text Add to dashboard Cite

The ambipolar band structure of graphene presents unique opportunities for novel electronic device applications. A cycle of gate voltage sweep in a conventional graphene transistor produces a frequency-doubled output current. To increase the frequency further, we used various graphene doping control techniques to produce Dirac voltage engineered graphene channels. The various surface treatments and substrate conditions produced differently doped graphene channels that were integrated on a single substrate and multiple Dirac voltages were observed by applying a single gate voltage sweep. We applied the Dirac voltage engineering techniques to graphene field-effect transistors on a single chip for the fabrication of a frequency multiplier and a logic inverter demonstrating analog and digital circuit application possibilities.

show abstract

Touch stimulated pulse generation in biomimetic single-layer graphene

Cited by 7 publications

References 29 publications

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Implantable Neural Interfaces and Wearable Tactile Systems for Bidirectional Neuroprosthetics Systems

Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice

Selective Dirac voltage engineering of individual graphene field-effect transistors for digital inverter and frequency multiplier integrations

Contact Info

Product

Resources

About