Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Ouyang, Chenguang; Yu, Haojie; Ni, Zhipeng; Liu, Xiaowei; Shen, Di; Yang, Jian; Shi, Kehang; Wang, Huanan

doi:10.1016/j.cis.2023.102982

Cited by 29 publications

(7 citation statements)

References 127 publications

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“…Moreover, hydrogels reveal exceptional ability to conform to various shapes and adhere to tissues, making them well-suited for irregularly shaped tissue defects. This allows for efficient and long-lasting repair at the site of the defect [ 72 , 73 ]. Thus, due to their distinctive features and adaptable abilities, hydrogels present intriguing opportunities for surpassing the constraints of conventional healing methods.…”

Section: Hydrogel-based Abdominal Wall Repairmentioning

confidence: 99%

Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

Liu,

Huang,

et al. 2024

Biomater Res

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The abdominal wall plays a crucial role in safeguarding the internal organs of the body, serving as an essential protective barrier. Defects in the abdominal wall are common due to surgery, infection, or trauma. Complex defects have limited self-healing capacity and require external intervention. Traditional treatments have drawbacks, and biomaterials have not fully achieved the desired outcomes. Hydrogel has emerged as a promising strategy that is extensively studied and applied in promoting tissue regeneration by filling or repairing damaged tissue due to its unique properties. This review summarizes the five prominent properties and advances in using hydrogels to enhance the healing and repair of abdominal wall defects: (a) good biocompatibility with host tissues that reduces adverse reactions and immune responses while supporting cell adhesion migration proliferation; (b) tunable mechanical properties matching those of the abdominal wall that adapt to normal movement deformations while reducing tissue stress, thereby influencing regulating cell behavior tissue regeneration; (c) drug carriers continuously delivering drugs and bioactive molecules to sites optimizing healing processes enhancing tissue regeneration; (d) promotion of cell interactions by simulating hydrated extracellular matrix environments, providing physical support, space, and cues for cell migration, adhesion, and proliferation; (e) easy manipulation and application in surgical procedures, allowing precise placement and close adhesion to the defective abdominal wall, providing mechanical support. Additionally, the advances of hydrogels for repairing defects in the abdominal wall are also mentioned. Finally, an overview is provided on the current obstacles and constraints faced by hydrogels, along with potential prospects in the repair of abdominal wall defects.

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Section: Hydrogel-based Abdominal Wall Repairmentioning

confidence: 99%

Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

Liu,

Huang,

et al. 2024

Biomater Res

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“…The inherent and diverse characteristics of hydrogels render them indispensable in the development of bioadhesives, artificial tissues, and biosensors. 488 , 659 – 662 Their unique and versatile properties, such as adhesiveness, hemostasis, and mechanical contraction, are critical for wound management and tissue repair. 663 Additionally, hydrogels facilitate the creation of bioengineered organs and tissues with realistic functionalities, opening new paths in regenerative medicine.…”

Section: Hydrogels For Non-cell Therapymentioning

confidence: 99%

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

Lu,

Ruan,

Huang

et al. 2024

Sig Transduct Target Ther

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The applications of hydrogels have expanded significantly due to their versatile, highly tunable properties and breakthroughs in biomaterial technologies. In this review, we cover the major achievements and the potential of hydrogels in therapeutic applications, focusing primarily on two areas: emerging cell-based therapies and promising non-cell therapeutic modalities. Within the context of cell therapy, we discuss the capacity of hydrogels to overcome the existing translational challenges faced by mainstream cell therapy paradigms, provide a detailed discussion on the advantages and principal design considerations of hydrogels for boosting the efficacy of cell therapy, as well as list specific examples of their applications in different disease scenarios. We then explore the potential of hydrogels in drug delivery, physical intervention therapies, and other non-cell therapeutic areas (e.g., bioadhesives, artificial tissues, and biosensors), emphasizing their utility beyond mere delivery vehicles. Additionally, we complement our discussion on the latest progress and challenges in the clinical application of hydrogels and outline future research directions, particularly in terms of integration with advanced biomanufacturing technologies. This review aims to present a comprehensive view and critical insights into the design and selection of hydrogels for both cell therapy and non-cell therapies, tailored to meet the therapeutic requirements of diverse diseases and situations.

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“…[23] In particular, thermosensitive hydrogels have drawn extensive attention owing to their moldability, biodegradability, and compositional and morphological similarity to tissues. [24] Injectable thermosensitive hydrogels show solto-gel transition at phase transition temperatures and can be developed by combining chitosan with glycerophosphates. [25,26] Therefore, the irregular skin wound could be filled perfectly due to injectable and thermosensitive abilities.…”

Section: Introductionmentioning

confidence: 99%

A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

Wu,

Wang,

Shen

et al. 2024

Adv Funct Materials

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Bacterial infection at wound sites can easily induce robust inflammation. M1 macrophages at wound sites can cause cascade inflammatory reactions to mediate a vicious inflammation cycle. Meanwhile, the hypoxia situation further aggravates the destruction and contraction of blood vessels in the wound microenvironment, therefore, hindering the infected wound healing process. Here, a thermosensitive hydrogel is reported to solve the above challenges by eliminating bacteria based on the photothermal effect, regulating the inflammatory immune microenvironment, and providing oxygen (O2). In vitro and in vivo experiments confirmed that the hydrogel has great O2‐producing properties. Based on the excellent photothermal properties of AIEgens, the hydrogel has a good bactericidal effect against S. aureus (100%) and E. coli (98.85%). The RNA‐sequencing revealed that Cur@AIE@MnO2/gel can interfere with the metabolic process and genetic material repair process to impact bacteria proliferation and biofilm dispersal, thus achieving excellent anti‐bacterial efficacy. Moreover, Cur@AIE@MnO2/gel can also up‐regulate anti‐inflammatory genes, down‐regulate pro‐inflammatory genes in macrophages, and facilitate the promotion of macrophage polarization from M1 to M2 to relieve inflammation. The therapeutic experiments show that this hydrogel accelerated the wound‐healing process. Therefore, this work may open new avenues for the development of novel dressings for bacterial‐infected wounds.

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Tough adhesion enhancing strategies for injectable hydrogel adhesives in biomedical applications

Cited by 29 publications

References 127 publications

Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

Recent Advances in Functional Hydrogel for Repair of Abdominal Wall Defects: A Review

Harnessing the potential of hydrogels for advanced therapeutic applications: current achievements and future directions

A Thermosensitive Hydrogel with Efficient NIR Photothermal Conversion as Injectable Wound Dressing for Accelerating Skin Wound Healing

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