Tough bonding of hydrogels to diverse non-porous surfaces

Yuk, Hyunwoo; Zhang, Teng; Lin, Shaoting; Parada, German Alberto; Zhao, Xuanhe

doi:10.1038/nmat4463

Cited by 938 publications

(907 citation statements)

References 45 publications

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“…However, highly stretchable alginate-polyacrylamide hydrogels may be adopted for large-scale production. [43] Additionally, the development of cladding methods that can bound to the core covalently will improve performance in vivo . [44] …”

Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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Optical fibers are widely used in biomedical applications for sensing, imaging, and therapies. Unlike existing solid-state optical fibers, soft polymer and hydrogel fibers offer physical and chemical properties well suited for functionalization with biomolecules and long-term implantation in the body. Here, hydrogel optical fibers are fabricated with glucose-sensitive moieties and the swelling-induced sensing is demonstrated. The core of the fiber is made of poly(acrylamide-co-poly(ethylene glycol) diacrylate) (p(AM-co-PEGDA)) hydrogel functionalized with phenylboronic acid. The complexation of the phenylboronic acid and cis diols of glucose molecules lowers the apparent pKa of the hydrogel network and increases the concentration of the boronate anions that enhances the Donnan osmotic pressure to swell and change the physical size of the hydrogel optical fiber. This mechanism is reversible through ester group dynamic covalent binding of the phenylboronic acid with glucose molecules. Dynamic changes in the effective RI of the hydrogel optical fiber are measured through light propagation loss. The sensor sensitivity to glucose concentration is 1.2 mmol L−1 over a physiological range of 1–12 mmol L−1. The biocompatible hydrogel optical fibers may be subcutaneously implanted for continuous monitoring of interstitial glucose concentrations.

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Section: Hydrogel Optical Fiber Sensorsmentioning

confidence: 99%

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

et al. 2017

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“…Soft elastic layers constrained between relatively rigid bodies appear in biological glues 1-4 , joints 5 and engineering applications including sealants, insulators, bearings, and adhesives 6, 7 . When the rigid bodies are pulled apart, the stressed layer can undergo various modes of mechanical instabilities due to a combination of the elastic layer's incompressibility, the mechanical constraints and the applied loads.…”

Section: Introductionmentioning

confidence: 99%

Fringe instability in constrained soft elastic layers

et al. 2016

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Soft elastic layers with top and bottom surfaces adhered to rigid bodies are abundant in biological organisms and engineering applications. As the rigid bodies are pulled apart, the stressed layer can exhibit various modes of mechanical instabilities. In cases where the layer's thickness is much smaller than its length and width, the dominant modes that have been studied are the cavitation, interfacial and fingering instabilities. Here we report a new mode of instability which emerges if the thickness of the constrained elastic layer is comparable to or smaller than its width. In this case, the middle portion along the layer's thickness elongates nearly uniformly while the constrained fringe portions of the layer deform nonuniformly. When the applied stretch reaches a critical value, the exposed free surfaces of the fringe portions begin to undulate periodically without debonding from the rigid bodies, giving the fringe instability. We use experiments, theory and numerical simulations to quantitatively explain the fringe instability and derive scaling laws for its critical stress, critical strain and wavelength. We show that in a force controlled setting the elastic fingering instability is associated with a snap-through buckling that does not exist for the fringe instability. The discovery of the fringe instability will not only advance the understanding of mechanical instabilities in soft materials but also have implications on biological and engineered adhesives and joints.

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“…More robust devices can be fabricated by using fiber-reinforced tough hydrogel (27). Robust bonding between the hydrogel and elastomer can be achieved by covalently anchoring the PAAm network on the elastomer substrate (15,18,26). The Escherichia coli bacterial strains were engineered to produce outputs [e.g., expressing GFP (green fluorescent protein)] under control of promoters that are inducible by cognate chemicals.…”

Section: Resultsmentioning

confidence: 99%

“…However, common hydrogels exhibit low mechanical robustness (14) and difficulty in bonding with other materials and devices (15), which have posed challenges in using them as matrices for living materials and devices (10). Significant progress has been made toward designing hydrogels with high mechanical toughness and stretchability (14,16,17) and robustly bonding hydrogels to engineering materials, such as glass, ceramics, metals, and elastomers (15,18,19). Combining programmed cells with robust biocompatible hydrogels has the potential to enable an avenue to create new living materials and devices, but this promising approach has not been explored yet.…”

mentioning

confidence: 99%

Stretchable living materials and devices with hydrogel–elastomer hybrids hosting programmed cells

Liu

Tang

Tham

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Living systems, such as bacteria, yeasts, and mammalian cells, can be genetically programmed with synthetic circuits that execute sensing, computing, memory, and response functions. Integrating these functional living components into materials and devices will provide powerful tools for scientific research and enable new technological applications. However, it has been a grand challenge to maintain the viability, functionality, and safety of living components in freestanding materials and devices, which frequently undergo deformations during applications. Here, we report the design of a set of living materials and devices based on stretchable, robust, and biocompatible hydrogel-elastomer hybrids that host various types of genetically engineered bacterial cells. The hydrogel provides sustainable supplies of water and nutrients, and the elastomer is air-permeable, maintaining long-term viability and functionality of the encapsulated cells. Communication between different bacterial strains and with the environment is achieved via diffusion of molecules in the hydrogel. The high stretchability and robustness of the hydrogel-elastomer hybrids prevent leakage of cells from the living materials and devices, even under large deformations. We show functions and applications of stretchable living sensors that are responsive to multiple chemicals in a variety of form factors, including skin patches and gloves-based sensors. We further develop a quantitative model that couples transportation of signaling molecules and cellular response to aid the design of future living materials and devices. hydrogels | synthetic biology | genetically engineered bacteria | biochemical sensors | wearable devices G enetically engineered cells enabled by synthetic biology have accomplished multiple programmable functions, including sensing (1), responding (2), computing (3), and recording (4). Powered by this emerging capability to program cells into living computers (1-6), the integration of genetically encoded cells into freestanding materials and devices will not only provide new tools for scientific research but also, lead to unprecedented technological applications (7). However, the development of such living materials and devices has been significantly hampered by the demanding requirements for maintaining viable and functional cells in materials and devices plus biosafety concerns toward the release of genetically modified organisms into environments. For example, gene networks embedded in paper matrices have been used for low-cost rapid viruses detection and protein manufacturing (1). However, their gene networks are based on freeze-dried extracts from genetically engineered cells to operate, partially because the paper substrates cannot sustain long-term viability and functionality of living cells or prevent their leakage. As another example, by seeding cardiomyocytes on thin elastomer films, biohybrid devices have been developed as soft actuators (8) and biomimetic robots (9). However, because the cells are not protected or isolated...

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Tough bonding of hydrogels to diverse non-porous surfaces

Cited by 938 publications

References 45 publications

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Glucose‐Sensitive Hydrogel Optical Fibers Functionalized with Phenylboronic Acid

Fringe instability in constrained soft elastic layers

Stretchable living materials and devices with hydrogel–elastomer hybrids hosting programmed cells

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