Toughening robocast chitosan/biphasic calcium phosphate composite scaffolds with silk fibroin: Tuning printable inks and scaffold structure for bone regeneration

Torres, Paula M.C.; Ribeiro, Nilza; Nunes, Carmen; Rodrigues, André; Sousa, Ana Catarina; Olhero, Susana M.

doi:10.1016/j.msec.2022.112690

Cited by 21 publications

(10 citation statements)

References 74 publications

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“…The authors concluded that these composites could induce sustained bone formation and be replaced by newly formed bone tissue, according to the long-term study. In a very interesting study, Torres et al [87] recently reported on the successful development of a chitosan network incorporating a high quantity of CaP particles that were usable as printable inks. The novel method for preparation was so-called robocasting (a low-temperature additive manufacturing technique).…”

Section: Chitosan-based Bioceramic Compositesmentioning

confidence: 99%

“…Obviously, for biomedical or clinical applications it is crucial that their mechanical properties meet the required strict standards. Taking this into account, the toughening of these types of composites is crucial and many research groups have focused on this area, with good and promising achievements [87][88][89]. The strength of composites is also dependent on their pore size and distributions For example, Iqbal et al [90] produced dicalcium phosphate dihydrate (DCPD) composite scaffolds with different DCPD concentrations (0-50 wt%), and reported that the increasing DCPD content resulted in higher crystallinity and reduction in pore size and distribution, observing mainly entwined and closed porosity.…”

Section: Chitosan-based Bioceramic Compositesmentioning

confidence: 99%

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Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Furkó

Balázsi

2023

Coatings

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Biocompatible ceramics are extremely important in bioengineering, and very useful in many biomedical or orthopedic applications because of their positive interactions with human tissues. There have been enormous efforts to develop bioceramic particles that cost-effectively meet high standards of quality. Among the numerous bioceramics, calcium phosphates are the most suitable since the main inorganic compound in human bones is hydroxyapatite, a specific phase of the calcium phosphates (CaPs). The CaPs can be applied as bone substitutes, types of cement, drug carriers, implants, or coatings. In addition, bioresorbable bioceramics have great potential in tissue engineering in their use as a scaffold that can advance the healing process of bones during the normal tissue repair process. On the other hand, the main disadvantages of bioceramics are their brittleness and poor mechanical properties. The newest advancement in CaPs doping with active biomolecules such as Mg, Zn, Sr, and others. Another set of similarly important materials in bioengineering are biopolymers. These include natural polymers such as collagen, cellulose acetate, gelatin, chitosan, and synthetic polymers, for example, polyvinyl pyrrolidone (PVP), polyvinyl alcohol (PVA), and polycaprolactone (PCL). Various types of polymer have unique properties that make them useful in different fields. The combination of CaP particles with different biopolymers gives rise to new opportunities for application, since their properties can be changed and adjusted to the given requirements. This review offers an insight into the most up-to-date advancements in the preparation and evaluation of different calcium phosphate–biopolymer composites, highlighting their application possibilities, which largely depend on the chemical and physical characteristics of CaPs and the applied polymer materials. Overall, these composites can be considered advanced materials in many important biomedical fields, with potential to improve the quality of healthcare and to assist in providing better outcomes as scaffolds in bone healing or in the integration of implants in orthopedic surgeries.

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Section: Chitosan-based Bioceramic Compositesmentioning

confidence: 99%

Section: Chitosan-based Bioceramic Compositesmentioning

confidence: 99%

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Furkó

Balázsi

2023

Coatings

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Section: Introductionmentioning

confidence: 99%

“…13 Therefore, SF and CS are often used together to produce various biological scaffold materials. 14,15 Moreover, tyrosine, the main component of silk fibroin, has a potent electron-donating ability, possibly allowing it to combine with nanoparticles. 16 To further improve the performance of SF-based materials, the introduction of multifunctional nanoparticles provides an efficient approach to achieving the required target properties for infectious bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

“…Antibacterial Activity of SF-Ag@QHMS In addition to improving the physical and chemical properties of the scaffold, nanoparticles could be employed to supply biologically active components, providing the scaffold with more biologically active functionalities. 15 Because of the dual mode antibacterial effects of direct contact killing by the long QAS chain covalently bonding to the surface and slow-released antibacterial of nano silver, the long chain of surface-modified quaternary ammonium salt changes cell permeability, our synthesized Ag@QHMS nanoparticles have exhibited satisfactory antibacterial efficacy against Escherichia coli, Staphylococcus aureus and Porphyromonas gingivalis. The inclusion of nanoparticles to the SF-Ag@QHMS resulted in antibacterial activity.…”

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confidence: 95%

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Multifunctional Mesoporous Silica Nanoparticles Reinforced Silk Fibroin Composite with Antibacterial and Osteogenic Effects for Infectious Bone Rehabilitation

Li¹,

Xie²,

Qiu³

et al. 2022

IJN

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Background Existing implant materials cannot meet the essential multifunctional requirements of repairing infected bone defects, such as antibacterial and osteogenesis abilities. A promising strategy to develop a versatile biomimicry composite of the natural bone structure may be accomplished by combining a multifunctional nanoparticle with an organic scaffold. Methods In this study, a quaternary ammonium silane-modified mesoporous silica containing nano silver (Ag@QHMS) was successfully synthesized and further combined with silk fibroin (SF) to fabricate the multifunctional nano-reinforced scaffold (SF-Ag@QHMS) using the freeze-drying method. Furthermore, the antibacterial and osteogenic effects of this composite were evaluated in vitro and in vivo. Results SF-Ag@QHMS inherited a three-dimensional porous structure (porosity rate: 91.90 ± 0.62%) and better mechanical characteristics (2.11 ± 0.06 kPa) than that of the SF scaffold (porosity rate: 91.62 ± 1.65%; mechanic strength: 2.02 ± 0.01 kPa). Simultaneously, the introduction of versatile nanoparticles has provided the composite with additional antibacterial ability against Porphyromonas gingivalis , which can be maintained for 15 days. Furthermore, the expression of osteogenic-associated factors was up-regulated due to the silver ions eluting from the composite scaffold. The in vivo micro-CT and histological results indicated that the new bone formation was not only localized around the border of the defect but also arose more in the center with the support of the composite. Conclusion The multifunctional silver-loaded mesoporous silica enhanced the mechanical strength of the composite while also ensuring greater and sustained antibacterial and osteogenic properties, allowing the SF-Ag@QHMS composite to be used to repair infected bone defects.

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Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

Carvalho

Torres

Belo

et al. 2023

Advanced NanoBiomed Research

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Diverse applications of nanoparticles (NP) have been revolutionary for various industrial sectors worldwide. In particular, magnetic nanoparticles (MNP) have gained great interest because of their applications in specialized medical areas. This review starts with a brief overview of the magnetic behavior of MNP and a short description of their most used synthesis methods. The second part is dedicated to the MNP applications in tissue engineering, emphasizing the calcium phosphate‐based NP with intrinsic magnetic properties, recently highlighted in the literature as alternative and viable solutions for bone regeneration. The challenges associated with the controversial long‐term toxicity effects of MNP can be overcome using this new generation of multifunctional bone‐like magnetic materials. Furthermore, the influence of magnetic field parameters, such as modality of application, intensity, and spatial distribution, on the biological behavior of magnetic materials, especially for bone repair, is shown. The last part of the review presents the current state of the art regarding the development of magnetic biomaterials for additive manufacturing (AM), aiming to fabricate scaffolds by AM technologies, focusing on bone tissue engineering applications.

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Toughening robocast chitosan/biphasic calcium phosphate composite scaffolds with silk fibroin: Tuning printable inks and scaffold structure for bone regeneration

Cited by 21 publications

References 74 publications

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Calcium Phosphate Loaded Biopolymer Composites—A Comprehensive Review on the Most Recent Progress and Promising Trends

Multifunctional Mesoporous Silica Nanoparticles Reinforced Silk Fibroin Composite with Antibacterial and Osteogenic Effects for Infectious Bone Rehabilitation

Bioactive Magnetic Materials in Bone Tissue Engineering: A Review of Recent Findings in CaP‐Based Particles and 3D‐Printed Scaffolds

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