Touraine-Solente-Gole syndrome with acne vulgaris successfully treated with isotretinoin

Abstract

Touraine-Solente-Gole syndrome or pachydermoperiostosis is a rare genodermatosis, affecting skin, bones and connective tissue, characterized by the triad of pachydermia, periostosis and digital clubbing. The authors report the case of a 26-year-old man presenting the dermato-rheumatic symptoms that characterize the complete form of the syndrome. He also manifested palpebral ptosis and severe acne treated with isotretinoin, in addition to exuberant polyarticular arthritis. Other causes of hypertrophic osteoarthropathy were investigated and not found. What's already known about this topic? i. Pachydermoperiostosis is a rare genodermatosis involving dermatologic (pachydermia) and rheumatologic alterations (periostosis and digital clubbing). ii. The condition affects more males than females, with the onset generally occurring towards the end of adolescence. iii. There is no specific treatment. What does this study add? iv. A rare severe case of pachydermoperiostosis with glandular hypertrophy (severe acne and blepharoptosis). v. Nodulocystic acne was successfully treated with isotretinoin. vi. A voluminous effusion was present in the knee joints with acute patellar dislocation.

Genotype and phenotype characterization of primary hypertrophic osteoarthropathy type 2 and chronic enteropathy associated with SLCO2A1: Report of two cases and literature review

“…Bone alterations are the result of an unbalance between osteogenesis and bone resorption since PGE2 mimics the activity of osteoblasts and osteoclasts. In addition, prolonged local vasodilatation is the cause of digital clubbing (Souza et al, 2018). Therefore, non-steroidal anti-inflammatory drugs (NSAIDs), particularly COX-2 inhibitors such as etoricoxib, have proven to be effective in treating skin and joint features (Li et al, 2017(Li et al, , 2018.…”