Toward a better identification and treatment of schizophrenia prodrome

Bota, Robert G.; Sagduyu, Kemal; Filin, Eugheniy E.; Bota, D.A.; Munro, Stuart

doi:10.1521/bumc.2008.72.3.210

Cited by 9 publications

(4 citation statements)

References 50 publications

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“…This has led to considerable interest and research activity internationally to study cohorts of ‘at risk’ younger siblings of children with a diagnosis from the first years of life. This contrasts to many other disorders in this special issue in which high‐risk genetic designs involve following offspring (sometimes as young as infancy) of parents diagnosed in adulthood (e.g., bipolar disorder: Chang et al, 2003; psychosis: Schubert & McNeil, 2004; schizophrenia: Bota, Sagduyu, Filin, Bota, & Munro, 2008). However, there are exceptions, including studying younger siblings of children with attention‐deficit/hyperactivity disorder (ADHD) (Faraone, Biederman, Mennin, & Russell, 1998) and dyslexia (Carroll & Snowling, 2004).…”

Section: What Can We Learn About the Prodrome Of Asds From Prospectivmentioning

confidence: 99%

The prodrome of autism: early behavioral and biological signs, regression, peri‐ and post‐natal development and genetics

Yirmiya

Charman²

2010

Child Psychology Psychiatry

187

124

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Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the 'core' disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical signs or indicators that will be present very early in life, certainly in infancy. A number of novel lines of investigation have been used to this end, including retrospective coding of home videos, prospective population screening and 'high risk' sibling studies; as well as the investigation of pre- and peri-natal, brain developmental and other biological factors. While no single prodromal sign is expected to be present in all cases, a picture is emerging of indicative prodromal signs in infancy and initial studies are being undertaken to attempt to ameliorate early presentation and even 'prevent' emergence of the full syndrome.

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Section: What Can We Learn About the Prodrome Of Asds From Prospectivmentioning

confidence: 99%

The prodrome of autism: early behavioral and biological signs, regression, peri‐ and post‐natal development and genetics

Yirmiya

Charman²

2010

Child Psychology Psychiatry

187

124

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“…Both prodromes and risk factors precede the onset of the syndrome; however, a prodrome indicates the initiation of the onset of the disorder whereas a risk factor identifies individuals who are at elevated risk for future emergence of the disorder. Although there is a long history of research on risk factors for psychiatric conditions, only recently have prodromes received research attention, primarily in the field of schizophrenia (Yung & McGorry, 1996; Bota, Sagduyu, Fillin, Bota, & Munro, 2008).…”

Section: Summary Of Terminologymentioning

confidence: 99%

Risk factors and prodromal eating pathology

Stice¹,

Ng²,

Shaw³

2010

Child Psychology Psychiatry

192

125

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Prospective studies have identified factors that increase risk for eating pathology onset, including perceived pressure for thinness, thin-ideal internalization, body dissatisfaction, dietary restraint, and negative affect. Research also suggests that body dissatisfaction and dietary restraint may constitute prodromal stages of the development of eating disorders. Prevention trials indicate that interventions that reduce pressure to be thin, thin-ideal internalization, body dissatisfaction, and negative affect significantly reduce eating disorder symptoms. Further, there is evidence that selective prevention programs that target young women at elevated risk for eating pathology by virtue of thin-ideal internalization, body dissatisfaction, and negative affect produce significant larger intervention effects than do universal programs offered to unselected populations. Thus, research on risk factors and prodromal stages of eating pathology has assisted in the design of efficacious prevention programs and the identification of high-risk individuals to target with these interventions; additional research in this area may lead to even more effective prevention programs.

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“…In current research and practice there is a growing interest in identifying an incipient psychosis at a very early stage (prodrome), as early intervention can improve the course of the disorder (for review see Bota et al, 2008;Harrigan et al, 2003;Resch, 2008;Riecher-Rössler et al, 2006;Serretti et al, 2009). A psychotic disorder mostly announces itself years before the first episode, in the so-called prodromal state, with unspecific signs and functional impairment.…”

Section: Introductionmentioning

confidence: 99%

The Self-screen-Prodrome as a short screening tool for pre-psychotic states

Müller

Vetter

Buchli-Kammermann

et al. 2010

Schizophrenia Research

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Background: Early detection of psychosis is an important issue in current research. Early intervention helps to improve the outcome of the disorder. Therefore, a comprehensive examination in large populations, necessary as it might be, is economically almost not feasible. A screening via self-report is more practicable as it helps focus on individuals with high symptom loads. Results: Both groups (cases and non-cases) showed significant differences in their mean scores on SPro and ESI, although only the SPro had satisfactory effect sizes. In hierarchic logistic regression models the SPro turned out to be highly predictive for caseness while ESI scales were not significant. A cut-off score of ≥2 on the Spro subscale for psychotic risk (SPro-Psy-Risk) was found to identify caseness best with a sensitivity of 74% and a specificity of 61%. Conclusion:The SPro has proven to be a valid and very economic screening tool for general and prodromal pathology in large populations.

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Toward a better identification and treatment of schizophrenia prodrome

Cited by 9 publications

References 50 publications

The prodrome of autism: early behavioral and biological signs, regression, peri‐ and post‐natal development and genetics

The prodrome of autism: early behavioral and biological signs, regression, peri‐ and post‐natal development and genetics

Risk factors and prodromal eating pathology

The Self-screen-Prodrome as a short screening tool for pre-psychotic states

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