Toward a chronotherapy of neoplasia: Tolerance of treatment depends upon host rhythms

Halberg, Franz; Haus, Erhard; Cardoso, Sílvia Almeida; Scheving, Lawrence E.; Kühl, J F; Shiotsuka, Ronald N.; Rosene, Gordon L.; Pauly, John E.; Runge, Walter; Spalding, J. F.; Lee, J. K.; Good, Robert A.

doi:10.1007/bf01930381

Cited by 138 publications

(38 citation statements)

References 34 publications

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“…As an implication, individualized chronotherapy, based on each patient's own circadian system, was advocated (Halberg et al, 1973). Such new therapeutic strategy should be based on some insights into the mechanisms for tumorassociated circadian-system alterations, which could be gained in specific experimental models and in clinical studies.…”

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confidence: 99%

Circadian-system alterations during cancer processes: A review

1997

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Murine and human data have indicated that tumors and tumor-bearing hosts may exhibit nearly normal or markedly altered circadian rhythms. Amplitude damping, phase shifts, and/or period (t) change, including appearance of ultradian rhythms (with t F 20 hr) usually become more prominent at late stages of cancer development. The extent of rhythm alterations also varies according to tumor type, growth rate and level of differentiation. While ''group chronotherapy,'' i.e., administration of the same chronomodulated schedule to cancer patients, has increased chemotherapy efficacy and/or tolerability, cancer patients' individual circadian rhythms now need to be explored on a large scale, in order to estimate the incidence of cancer-associated circadian-system alterations and to understand the underlying mechanisms. Correlations between such alterations and patient outcome must be established in order to specify the need for individualized chronomodulated delivery schedules and/or specific rhythmoriented therapy, especially in patients with circadian-system disturbances. Int. J. Cancer, 70:241-247, 1997.r 1997 Wiley-Liss, Inc.Biological functions are modulated by rhythms along several periodic time-scales, i.e., ultradian (with a period, t, shorter than 20 hr), circadian (t approx. 24 hr) or infradian (t . 28 hr). Circadian rhythms are endogenous, genetically based, and coordinated by at least one biological clock, the supra-chiasmatic nucleus (SCN). The circadian periodicity of the SCN can be calibrated by environmental cycles with a t approaching 24 hr. The 24-hr light-dark cycle plays such a role, via specific neuronal pathways and neuromediators, and via darkness-induced secretion of melatonin.

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confidence: 99%

Circadian-system alterations during cancer processes: A review

1997

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“…The following equation is used to find the Compressibility index. [19] Compressibility Index = (Tapped Density-Bulk Density)/Tapped DensityX100…”

Section: Bulk Density = W / Vo and Tapped Density = W / V Fmentioning

confidence: 99%

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Ganesh¹

2017

WJPPS

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The main aim of the proposed work was to develop Tramadol matrix tablets, sustained release dosage form. Tramadol is a narcotic analgesic proposed for moderate to severe pain Sustained release formulation is the drug delivery system that is designed to achieve a prolonged therapeutic effect by continuously releasing medication over an extended period of time after administration of a single dose. The sustained release tablets were prepared by direct compression method using Hydroxypropyl methyl cellulose as a K100M grade, Karayagum and Guar gum in varying ratios. Tablets blends were evaluated for Bulk density, Tapped density, compressibility index and angle of repose, shows satisfactory results. The compressed tablets were then evaluated for various physical tests like diameter, thickness, uniformity of weight, hardness, friability and drug content. The granules exhibited satisfactory rheological demeanor. The results of all these

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“…Relative Sodium vs. Potassium Excretion Since the promotion of increased sodium excretion may be regarded as a beneficial effect of hydrochlorothiazide and the promotion of potassium excretion as a toxic effect, a ratio of the relative rates has been used to summarize a chronotherapeutic index [6,7,10,15]. In our data this ratio clearly indicates optimum effect in the late evening [I] (fig.…”

Section: Chrono-chloriuresis and Natriuresismentioning

confidence: 99%

“…Applied chronobiology, e.g. chronopharmacology, investigates drug effects as a function of biological timing, and chronotherapy refers to the optimization of drug therapy that follows from this information, e.g., the specific prescription of an anticancer drug along the circadian time scale to improve the thera peutic ratio [6,7], …”

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Hydrochlorothiazide Diuresis in Healthy Man: Review of the Orcadian Mediation

Hw¹

1979

Nephron

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This is a review of evidence for a circadian-mediated pharmacology of a single dose of hydrochlorothiazide in normal man. The normal circadian rhythms of urine volume and electrolytes are discussed in detail. Information is documented that hydrochlorothiazide diuresis, in normal subjects on a normal schedule of diurnal activity/nocturnal rest, progressively increases for 4 h after a.m. administration and for 8 h after p.m. administration. This suggests that the therapeutic efficiency of a single dose may be enhanced (nearly 50%) by the simple expedient of prescribing in the afternoon. No information is provided as to whether the circadian-mediated response appertains in disease or with continued drug administration. The word ‘circadian’ is not found in classical pharmacological texts although many examples of circadian-mediated drug action have now been described. A circadian reappraisal of drug effects in general is overdue.

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Toward a chronotherapy of neoplasia: Tolerance of treatment depends upon host rhythms

Cited by 138 publications

References 34 publications

Circadian-system alterations during cancer processes: A review

Circadian-system alterations during cancer processes: A review

Formulation and Evaluation of Sustained Release Tablets of Tramadol

Hydrochlorothiazide Diuresis in Healthy Man: Review of the Orcadian Mediation

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