Toward a unified pathophysiology in COVID-19 acute aortopathies

Roncati, Luca; Manenti, Antonio; Farinetti, Alberto; Manco, Gianrocco; Mattioli, Anna Vittoria

doi:10.1016/j.jvs.2021.07.131

Cited by 4 publications

(3 citation statements)

References 7 publications

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“…Moreover, Strazzulla et al [ 12 ] discovered that the total number of neutrophils (OR:1.20; 95% CI:1.04–1.40; p = 0.01) and lymphocytes (OR:0.45; 95% CI:0.23–0.86; p = 0.01) were independently associated with acute pulmonary embolism a cohort of 184 COVID-19 patients. Furthermore, Roncati L. et al explained the influence of an abnormal inflammatory response in severe COVID-19 patients on pro-coagulant status through platelet release [ 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients

Arbănași¹,

Hălmaciu

Kaller³

et al. 2022

Diagnostics

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Background: Numerous tools, including inflammatory biomarkers and lung injury severity scores, have been evaluated as predictors of thromboembolic events and the requirement for intensive therapy in COVID-19 patients. This study aims to verify the predictive role of inflammatory biomarkers [monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), systemic inflammatory index (SII), Systemic Inflammation Response Index (SIRI), and Aggregate Index of Systemic Inflammation (AISI)] and the CT Severity Score in acute limb ischemia (ALI) risk, intensive unit care (ICU) admission, and mortality in COVID-19 patients.; Methods: The present study was designed as an observational, analytical, retrospective cohort study and included all patients older than 18 years of age with a diagnosis of COVID-19 infection, confirmed through real time-polymerase chain reaction (RT-PCR), and admitted to the County Emergency Clinical Hospital of Targu-Mureș, Romania, and Modular Intensive Care Unit of UMFST “George Emil Palade” of Targu Mures, Romania between January 2020 and December 2021. Results: Non-Survivors and “ALI” patients were associated with higher incidence of cardiovascular disease [atrial fibrillation (AF) p = 0.0006 and p = 0.0001; peripheral arterial disease (PAD) p = 0.006 and p < 0.0001], and higher pulmonary parenchyma involvement (p < 0.0001). Multivariate analysis showed a high baseline value for MLR, NLR, PLR, SII, SIRI, AISI, and the CT Severity Score independent predictor of adverse outcomes for all recruited patients (all p < 0.0001). Moreover, the presence of AF and PAD was an independent predictor of ALI risk and mortality. Conclusions: According to our findings, higher MLR, NLR, PLR, SII, SIRI, AISI, and CT Severity Score values at admission strongly predict ALI risk, ICU admission, and mortality. Moreover, patients with AF and PAD had highly predicted ALI risk and mortality but no ICU admission.

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Section: Discussionmentioning

confidence: 99%

Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients

Arbănași¹,

Hălmaciu

Kaller³

et al. 2022

Diagnostics

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“…In fact, it has been estimated that over 30% of patients admitted to intensive care with COVID-19 suffer from systemic thromboembolism, including from aortic thrombi ( Klok et al, 2020 , Buikema et al, 2021 ). In addition, the infection often leads to thrombosis in non-atherosclerotic vessels ( de Roquetaillade et al, 2021 ): this occurrence is likely mediated by the viral-induced apoptosis of vascular endothelial cells and subsequent mononuclear infiltration with development of a severe leukocytoclastic vasculitis; newly formed antiphospholipid antibodies along with COVID-19-coagulopathy then promote local vascular thromboses ( Roncati et al, 2021 ). Nevertheless, aortic thrombosis could also be an innocent bystander in the case of acute ischemic stroke, even in COVID-19 patients ( Kashi et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Acute ischemic stroke due to floating thrombus of ascending aorta: An acute and subacute complication of SARS-CoV-2 infection

Manna

Bax

Sponga

et al. 2022

Neuroimmunology Reports

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“…Aneurysms can increase in size owing to activated metalloproteinases, and typically in the aorta, can result in vasa vasorum thrombosis, increasing the risk of rupture. 6 Similarly, in cardiomyocytes, COVID-19 virions will accelerate their apoptosis, followed by myocardial invasion of inflammatory cells, typically lymphocytes. The consequent myocarditis favors the occurrence of dysrhythmia, decreases the ventricles’ ejection fraction, and can lead to a secondary myocardial fibrosis.…”

mentioning

confidence: 99%

From coronavirus disease 2019 to long coronavirus disease 2019 in vascular pathology

Farinetti

Manenti

Manco

et al. 2022

Journal of Vascular Surgery

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Toward a unified pathophysiology in COVID-19 acute aortopathies

Cited by 4 publications

References 7 publications

Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients

Systemic Inflammatory Biomarkers and Chest CT Findings as Predictors of Acute Limb Ischemia Risk, Intensive Care Unit Admission, and Mortality in COVID-19 Patients

Acute ischemic stroke due to floating thrombus of ascending aorta: An acute and subacute complication of SARS-CoV-2 infection

From coronavirus disease 2019 to long coronavirus disease 2019 in vascular pathology

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