Toward an efficient antibacterial agent: Zn- and Mg-doped hydroxyapatite nanopowders

Alioui, Houria; Bouras, Omar; Bollinger, Jean‐Claude

doi:10.1080/10934529.2018.1550292

Cited by 43 publications

(16 citation statements)

References 61 publications

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“…In the present study, according to the ultrasound measurement results, a slight change in suspension stability was observed after 3000 s, while in a previous study of the 10MgHAp solution [30], a drastic change in suspension stability was observed after only 100 s. Consequently, the inhibition of the biofilm development was also stronger in the case of the 10MgHAp-Dex-thyme layers with respect to the one reported in [30] for the 10MgHAp solutions. The results obtained in our study were in good agreement with the literature in what concerns the antimicrobial properties of Mg-based composites and EO compounds [22,28,29,[59][60][61][62][63].…”

Section: Resultssupporting

confidence: 91%

“…The antimicrobial properties of thyme EO have been previously reported against a pathogenic and/or spoilage food-related bacterium [26,27], as well as against common bacterial strains, such as Staphylococcus aureus and Listeria monocytogenes [23]. Nonetheless, there are several emerging cations with both antimicrobial properties and important roles in the enhancement of the biological interactions of HAp with the surrounding tissues, amid which Mg 2+ comes into prominence [28][29][30]. Magnesium is one of the most important essential trace elements, being involved in the development of bones and connective tissues and possessing osteogenic and angiogenic stimulating properties, demonstrated both in vitro and in vivo [31][32][33][34][35].…”

Section: Introductionmentioning

confidence: 99%

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Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

et al. 2020

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The dextran-thyme magnesium-doped hydroxyapatite (10MgHAp-Dex-thyme) composite layers were prepared by a dip-coating procedure from stable suspensions and further analyzed for the first time. Different characterization techniques were employed to explore the physical-chemical features of the 10MgHAp-Dex-thyme suspensions and derived coatings. Information regarding the 10MgHAp-Dex-thyme suspensions was extracted on the basis of dynamic light scattering, zeta potential, and ultrasound measurements. The crystalline quality of the biocomposite powders—resulting after the centrifugation of suspensions—and the layers deposited on glass was assessed by X-ray diffraction in symmetric and grazing incidence geometries, respectively. The chemical structure and presence of functional groups were evaluated for both powder and coating by Fourier transform infrared spectroscopy in attenuated total reflectance mode. The extent of the antimicrobial effect range of the biocomposite suspensions and coatings was tested against different Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa) and fungus (Candida albicans) strains with promising results.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

et al. 2020

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“…Due to Zn beneficial effects on bone formation, the synthesis of substituted HAP with Zn (HAP-Zn) has been carried out by using chemical precipitation methods for different Zn substitution levels into the HAP lattice. 16,[47][48][49][50] Silicon, Si, was found to be essential in bone growth and development. 51 This discovery has inspired the development of bioceramics based on Si-substituted hydroxyapatite (HAP-Si), [52][53][54][55][56][57] primarily by using precipitation routes.…”

Section: Introductionmentioning

confidence: 99%

“…57 As shown above, there are many experimental studies on mono-substituted HAP with Sr, Mg, Zn, or Si, whereas there are only a few about double-substituted HAPs with these elements, for instance HAP-Mg-Zn. 50 Co-substitution of Mg and Sr within HAP lattice (HAP-Mg-Sr) has been carried out 41,58 and ensured an improved biological response. The Sr and Zn co-substituted HAP was shown to present excellent osteoinductivity and antibacterial properties.…”

Section: Introductionmentioning

confidence: 99%

<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

Garbo

Ločs

D’Este

et al. 2020

IJN

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Purpose: Compositional tailoring is gaining more attention in the development of advanced biomimetic nanomaterials. In this study, we aimed to prepare advanced multi-substituted hydroxyapatites (ms-HAPs), which show similarity with the inorganic phase of bones and might have therapeutic potential for bone regeneration. Materials: Novel nano hydroxyapatites substituted simultaneously with divalent cations: Mg 2+ (1.5%), Zn 2+ (0.2%), Sr 2+ (5% and 10%), and Si (0.2%) as orthosilicate (SiO 4 4-) were designed and successfully synthesized for the first time. Methods: The ms-HAPs were obtained via a wet-chemistry precipitation route without the use of surfactants, which is a safe and ecologically friendly method. The composition of synthesized materials was determined by inductively coupled plasma optical emission spectrometry (ICP-OES). The materials were characterized by X-ray powder diffraction (XRD), FT-IR and FT-Raman spectroscopy, BET measurements and by imaging techniques using highresolution TEM (HR-TEM), FE-SEM coupled with EDX, and atomic force microscopy (AFM). The ion release was measured in water and in simulated body fluid (SBF). Results: Characterization methods confirmed the presence of the unique phase of pure stoichiometric HAP structure and high compositional purity of all synthesized nanomaterials. The doping elements influenced the crystallite size, the crystallinity, lattice parameters, morphology, particle size and shape, specific surface area, and porosity. Results showed a decrease in both nanoparticle size and crystallinity degree, coupled with an increase in specific surface area of these advanced ms-HAP materials, in comparison with pure stoichiometric HAP. The release of biologically important ions was confirmed in different liquid media, both in static and simulated dynamic conditions. Conclusion: The incorporation of the four substituting elements into the HAP structure is demonstrated. Synthesized nanostructured ms-HAP materials might inherit the in vivo effects of substituting functional elements and properties of hydroxyapatite for bone healing and regeneration. Results revealed a rational tailoring approach for the design of a next generation of bioactive ms-HAPs as promising candidates for bone regeneration.

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“…To avoid such issues, doping ceramics with metallic compounds with inherent antibacterial properties can replace the use of antibiotics. In this regard, metal ions, including copper, silver, iron, titanium, strontium, manganese, and zinc, have been doped successfully into bioceramic and hybrid scaffolds, enhancing their anti-infective properties [164][165][166][167][168][169][170][171][172][173][174].…”

Section: Bone Substitutesmentioning

confidence: 99%

Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

Bădilă

Rădulescu

Niculescu

et al. 2021

Cancers

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In the last decades, the treatment of primary and secondary bone tumors has faced a slow-down in its development, being mainly based on chemotherapy, radiotherapy, and surgical interventions. However, these conventional therapeutic strategies present a series of disadvantages (e.g., multidrug resistance, tumor recurrence, severe side effects, formation of large bone defects), which limit their application and efficacy. In recent years, these procedures were combined with several adjuvant therapies, with different degrees of success. To overcome the drawbacks of current therapies and improve treatment outcomes, other strategies started being investigated, like carrier-mediated drug delivery, bone substitutes for repairing bone defects, and multifunctional scaffolds with bone tissue regeneration and antitumor properties. Thus, this paper aims to present the types of bone tumors and their current treatment approaches, further focusing on the recent advances in new therapeutic alternatives.

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Toward an efficient antibacterial agent: Zn- and Mg-doped hydroxyapatite nanopowders

Cited by 43 publications

References 61 publications

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

Dextran-Thyme Magnesium-Doped Hydroxyapatite Composite Antimicrobial Coatings

<p>Advanced Mg, Zn, Sr, Si Multi-Substituted Hydroxyapatites for Bone Regeneration</p>

Recent Advances in the Treatment of Bone Metastases and Primary Bone Tumors: An Up-to-Date Review

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