Toward Clinical Cancer Imaging Using Terahertz Spectroscopy

Cheon, Hwayeong; Yang, Hee-Jin; Son, Joo‐Hiuk

doi:10.1109/jstqe.2017.2704905

Cited by 92 publications

(51 citation statements)

References 93 publications

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“…Research in the terahertz (THz) regime, which is the frequency range spanning between 0.1-10 THz in the electromagnetic spectrum, is gaining attention due its promising applications in significant fields such as biosensing, security, imaging, and spectroscopy [1,2]. While the reported works in the literature are based on different technologies [3][4][5][6][7][8][9][10], it is only recently that photonic crystal fibers (PCFs) are being considered for THz sensing applications [11][12][13]. This is because PCFs offer tremendous design flexibility over the conventional fibers.…”

Section: Introductionmentioning

confidence: 99%

A Highly Sensitive, Polarization Maintaining Photonic Crystal Fiber Sensor Operating in the THz Regime

2018

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In this paper, a high sensitivity, polarization preserving photonic crystal fiber (PCF), based on circular air holes for sensing in the terahertz (THz) band, is presented. The finite element method, a practical and precise computational technique for describing the interactions between light and matter, is used to compute the modal properties of the designed fiber. For the designed PCF, comprising of circular air holes in both the cladding and in the porous core, a relative sensitivity of 73.5% and a high birefringence of 0.013 are achieved at 1.6 THz. The all circular air-hole structure, owing to its simplicity and compatibility with the current fiber draw technique for PCF fabrication, can be realized practically. It is anticipated that the designed fiber can be employed in applications such as detection of biological samples and toxic chemicals, imaging, and spectroscopy.

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Section: Introductionmentioning

confidence: 99%

A Highly Sensitive, Polarization Maintaining Photonic Crystal Fiber Sensor Operating in the THz Regime

2018

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“…[4,5,[7][8][9][10]15,[22][23][24] Nevertheless, a challenge still open is how to achieve reliable sensing when the measured sample amount is very small. These properties have given rise to a powerful research line, and indeed, the list of biological applications of THz is extensive and in continuous development so the interested reader is referred to some recent books and reviews devoted to the topic.…”

mentioning

confidence: 99%

Terahertz Sensing Based on Metasurfaces

Beruete

Jáuregui-López

2019

Advanced Optical Materials

283

113

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The terahertz (THz) band has very attractive characteristics for sensing and biosensing applications, due to some interesting features such as being a non‐ionizing radiation, very sensitive to weak interactions, thus, complementing typical spectroscopy systems in the infrared. However, a fundamental drawback is its relatively long wavelength (10–1000 µm) which makes it blind to small features, hindering seriously both thin‐film and biological sensing. Recently, new ways to overcome this limitation have become possible thanks to the advent of metasurfaces. These artificial structures are planar screens usually made of periodic metallic resonators and whose electromagnetic response can be controlled at will by design. This design freedom allows metasurfaces to surpass the restrictions of classical THz spectroscopy, by creating fine details comparable to the size of the thin films or microorganisms under test. The strong field concentration near these small metasurface details at resonance makes them highly sensitive to tiny variations in the nearby environment, allowing for an enhanced detection more accurate than classical THz spectroscopy. The main advances in THz metasurface sensors from a historical as well as application‐oriented perspective are summarized. The focus is put mainly on thin‐film and biological sensors, with an aim to cover the most recent advances in the topic.

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“…In fact, the strong absorption of water limits the penetration depth in fresh tissues between tens and hundreds of microns. For example, into the human skin THz waves can penetrate only a few hundred microns [143]. In vivo clinical measurements, it limits the probing on superficial layers of the target and the reflection mode becomes the suitable choice [144,145].…”

Section: Thz Pulsed Imaging: Uses Advantages and Challenges For Biommentioning

confidence: 99%

“…The problems with handling fresh tissue, such as time variability in the THz bandwidth, dynamic range and sample thickness, are therefore overcome [153]. Several studies proposed the freezing of biological sample, as an alternative technique to increase the penetration depth of THz waves in the tissues, as the absorption coefficient of ice is one order of magnitude lower than the absorption coefficient of water [143]. The discussed technique has a limitation in clinical use; the process of freezing might cause necrosis.…”

Section: Thz Pulsed Imaging: Uses Advantages and Challenges For Biommentioning

confidence: 99%

THz Pulsed Imaging in Biomedical Applications

et al. 2020

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Recent advances in technology have allowed the production and the coherent detection of sub-ps pulses of terahertz (THz) radiation. Therefore, the potentialities of this technique have been readily recognized for THz spectroscopy and imaging in biomedicine. In particular, THz pulsed imaging (TPI) has rapidly increased its applications in the last decade. In this paper, we present a short review of TPI, discussing its basic principles and performances, and its state-of-the-art applications on biomedical systems.

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Toward Clinical Cancer Imaging Using Terahertz Spectroscopy

Cited by 92 publications

References 93 publications

A Highly Sensitive, Polarization Maintaining Photonic Crystal Fiber Sensor Operating in the THz Regime

A Highly Sensitive, Polarization Maintaining Photonic Crystal Fiber Sensor Operating in the THz Regime

Terahertz Sensing Based on Metasurfaces

THz Pulsed Imaging in Biomedical Applications

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