2021
DOI: 10.1055/s-0041-1722864
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Toward Personalized Treatment for Patients with Low von Willebrand Factor and Quantitative von Willebrand Disease

Abstract: The biological mechanisms involved in the pathogenesis of type 2 and type 3 von Willebrand disease (VWD) have been studied extensively. In contrast, although accounting for the majority of VWD cases, the pathobiology underlying partial quantitative VWD has remained somewhat elusive. However, important insights have been attained following several recent cohort studies that have investigated mechanisms in patients with type 1 VWD and low von Willebrand factor (VWF), respectively. These studies have demonstrated… Show more

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Cited by 4 publications
(3 citation statements)
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“…Tranexamic acid should strongly be considered for PPH for all IBD patients. Data supports that levels previously often thought to be sufficient for hemostasis (i.e., ≥50%) are likely insufficient for the hemostatic challenge of pregnancy 66 . In infants known or at risk to inherit a severe bleeding disorder, a well‐resourced delivery setting is needed and a C‐section should be considered.…”
Section: Discussion: Pregnancy In Ibdsmentioning
confidence: 91%
See 1 more Smart Citation
“…Tranexamic acid should strongly be considered for PPH for all IBD patients. Data supports that levels previously often thought to be sufficient for hemostasis (i.e., ≥50%) are likely insufficient for the hemostatic challenge of pregnancy 66 . In infants known or at risk to inherit a severe bleeding disorder, a well‐resourced delivery setting is needed and a C‐section should be considered.…”
Section: Discussion: Pregnancy In Ibdsmentioning
confidence: 91%
“…Data supports that levels previously often thought to be sufficient for hemostasis (i.e., ≥50%) are likely insufficient for the hemostatic challenge of pregnancy. 66 In infants known or at risk to inherit a severe bleeding disorder, a wellresourced delivery setting is needed and a C-section should be considered. More research is needed to develop much-needed evidence to inform guidance and improve care.…”
Section: Discussion: Preg Nan C Y In Ib Dsmentioning
confidence: 99%
“…12 Similarly, O'Donnell reports on subgroups of patients with partial quantitative VWD, where bleeding risk does not correlate with plasma von Willebrand factor (VWF) levels. 13 This review highlights the important advances that have been made in our understanding of VWD pathophysiology, including stratification of patients into distinct VWD subgroups, as well as understanding the heterogeneity in response to current therapeutic regimens. Critically, defining optimal therapeutic VWF target levels is of particular clinical importance with respect to designing personalized treatment plans for VWD patients undergoing surgical procedures.…”
mentioning
confidence: 99%