Toward Portable Instrumentation for Quantitative Cocaine Detection with Lab-on-a-Paper and Hybrid Optical Readout

Abstract

Detection of cocaine on the level of a few ng/ml by the use of lab-on-a-paper test co-working with OLED light source as exciatation light source and CCD-based detection unit is described in this paper. The new method enables not only yes or now answer of drug presence in a tested sample but also concentration of the drug in the sample. Presented here results opens a new way toward portable instrumentation for point-of-care detection of cocaine (and in the future other drugs) in sweat of for example professional drivers. This device will be a drug-tester similar to widely now used alcohol testers

Lab-on-a-chip fluorescence detection with image sensor and software-based image conditioning

“…14b) [26]. Recent works on the hand-held reader equipped with a miniature laser instead of OLED confirmed high sensitivity of the detection unit [27,28]. Reported the lowest detection limit of cocaine was better than 2 ng/ml which fulfills new requirements for the lowest detection limit.…”

Ultrasensitive Detection and Binding Mechanism of Cocaine in an Aptamer‐based Single‐molecule Device

“…Till today, various aptasensors have been developed for cocaine detection. According to the signal detected, they can be mainly divided into two types: i) optical method and ii) electrical method . The commonly‐used optical methods contain fluorescence‐based aptasensors, colorimetric aptasensors, chemiluminescence‐based aptasensors and SERS‐based aptasensors .…”

The Implementation of Fluorescence‐Based Detection in LTCC (Low‐Temperature‐Co‐Fired‐Ceramics) Microfluidic Modules

“…15 The majority of microfluidic systems with optical detection that have been presented in literature use external lasers, halogen lamps, LEDs and spectrometers, and microscopes or digital cameras as light sources and light sensors, respectively. [15][16][17][18][19][20][21] These optical and optoelectronic components are, however, rather bulky and cannot be integrated into the microfluidic structure. The aim of this presented research was to develop a microfluidic system for fluorescence measurement with low-cost and commercially available optoelectronic components that are integrated on-chip.…”

“…Therefore, it can be used in the development of a microfluidic cytometer or a miniature real‐time PCR (polymerase chain reaction) system . The majority of microfluidic systems with optical detection that have been presented in literature use external lasers, halogen lamps, LEDs and spectrometers, and microscopes or digital cameras as light sources and light sensors, respectively . These optical and optoelectronic components are, however, rather bulky and cannot be integrated into the microfluidic structure.…”