Toward Precision Medicine: Promising Areas of Research in Glioma

Davis, Mary E.; Bossert, Dana; Manne, Malbora

doi:10.1016/j.soncn.2018.10.012

Cited by 2 publications

(2 citation statements)

References 21 publications

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“…Using a negative-depletion system to remove leucocytes and subsequently enrich for CTCs, another study identified CTCs in 39% of participating patients with glioblastoma. 26 These data reflect the presence of CTCs in the peripheral blood of patients with glioma, but as CTCs are estimated to be present at a rate of one CTC per 1×10 9 blood cells, 31 the scarcity of these cells remains a major limitation. On a positive note and despite the variation in detection rates between studies, the presence of CTCs in the peripheral bloodstream is reflective of their ability to surpass the BBB.…”

Section: Circulating Tumour Cellsmentioning

confidence: 99%

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

et al. 2020

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Gliomas are the most common central nervous system malignancies and present with significant morbidity and mortality. Treatment modalities are currently limited to surgical resection, chemotherapy and radiotherapy. Increases in survival rate over the previous decades are negligible, further pinpointing an unmet clinical need in this field. There is a continual struggle with the development of effective glioma diagnostics and therapeutics, largely due to a multitude of factors, including the presence of the blood–brain barrier and significant intertumoural and intratumoural heterogeneity. Importantly, there is a lack of reliable biomarkers for glioma, particularly in aiding tumour subtyping and measuring response to therapy. There is a need for biomarkers that would both overcome the complexity of the disease and allow for a minimally invasive means of detection and analysis. This is a comprehensive review evaluating the potential of current cellular, proteomic and molecular biomarker candidates for glioma. Significant hurdles faced in glioma diagnostics and therapy are also discussed here.

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Section: Circulating Tumour Cellsmentioning

confidence: 99%

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

et al. 2020

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“…This showed the eight-step process combined with four-track cross-over quality control interventions could effectively promote the postoperative recovery of patients with glioma. This is because the eight-step process interventions formulate a scientific nursing process, allowing intervention staff to quickly grasp the key points when implementing nursing operations and reducing nursing errors (17,18). Further, the use of the four-track cross-over quality control intervention in the nursing process involving features such as vital signs monitoring, complications prevention, and pipeline management can not only implement real-time monitoring of postoperative nursing work, but also supervise and intervene to complete various postoperative nursing tasks avoiding nursing omissions (19).…”

Section: Discussionmentioning

confidence: 99%

Observation of the impact of the eight-step process combined with the four-track crossover quality control applied to patients with glioma surgery: a randomised trial

Zhang

et al. 2021

Ann Transl Med

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Background: At present, surgery is the main treatment for patients with glioma, but there are certain risks in the operation. The traction and stress reaction of related brain tissue during surgery can cause complications such as cerebral edema, which adversely affects the prognosis of patients. The purpose of the present study was to explore the effect of an eight-step process combined with four-track quality control applied to patients undergoing glioma surgery.Methods: A total of 122 patients undergoing glioma surgery admitted to our hospital from March 2017 to March 2020 were selected and divided into two groups according to the random number table method, each with 61 cases. The control group underwent routine intervention after surgery and the observation group underwent an eight-step process combined with four-track cross-over quality control intervention after surgery. The postoperative rehabilitation effects, cancer-related fatigue, changes in quality of life, and the incidence of complications before and after intervention were compared between the two groups.Results: The time of catheter removal, the time of first eating, the time of getting out of bed, and the length of hospital stay of the observation group were shorter than those of the control group (P<0.05). In the observation group cognitive fatigue, physical fatigue, and emotional fatigue scores were lower than those of the control group after intervention (P<0.05) and the quality-of-life scores of the observation group after intervention were higher than those of the control group (P<0.05). The total incidence of complications in the observation group was lower than that of the control group (P<0.05). Conclusions:The eight-step process combined with four-track quality control applied to patients undergoing glioma surgery can reduce cancer-related fatigue, improve quality of life, reduce complications, and promote speedy recovery.

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Toward Precision Medicine: Promising Areas of Research in Glioma

Cited by 2 publications

References 21 publications

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Potential biomarkers and challenges in glioma diagnosis, therapy and prognosis

Observation of the impact of the eight-step process combined with the four-track crossover quality control applied to patients with glioma surgery: a randomised trial

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